Tracking temporal response dynamics in the ventral striatum during social feedback in anorexia nervosa

Objective: Research suggests abnormalities in reward-based processes in anorexia nervosa (AN). However, few studies have explored if such alterations might be associated with different temporal activation patterns. This study aims to characterize alterations in time-dependent processes in the ventra...

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Detalles Bibliográficos
Autores: Membrives, Sonia|||0000-0002-0439-7936, López-Solà, Marina|||0000-0002-5517-2665, Fernández Aranda, Fernando|||0000-0002-2968-9898, Sánchez Díaz, Isabel María|||0000-0001-5874-8204, Martínez-Zalacaín, Ignacio|||0000-0002-4036-0284, Palao, Diego|||0000-0002-3323-6568, Pujol Nuez, Jesús|||0000-0002-9946-4547, Menchón Magriñá, José Manuel|||0000-0002-6231-6524, Davey, Chris G., Harrison, Ben J., Keating, Charlotte, Rossell, Susan L., Oliva, Joan Carles|||0000-0003-1273-2746, Soriano-Mas, Carles|||0000-0003-4574-6597, Cardoner, Narcís|||0000-0001-9633-0888, Via, Esther|||0000-0002-2331-3232
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:311424
Acceso en línea:https://ddd.uab.cat/record/311424
https://dx.doi.org/urn:doi:10.1002/eat.23604
Access Level:acceso abierto
Palabra clave:Anorexia nervosa
Functional magnetic resonance imaging
Reward system
Social reward
Ventral striatum
Descripción
Sumario:Objective: Research suggests abnormalities in reward-based processes in anorexia nervosa (AN). However, few studies have explored if such alterations might be associated with different temporal activation patterns. This study aims to characterize alterations in time-dependent processes in the ventral striatum (VS) during social feedback in AN using functional magnetic resonance imaging (fMRI). Method: Twenty women with restrictive-subtype AN and 20 age-matched healthy controls (HC) underwent a social judgment experimental fMRI task. Temporal VS hemodynamic responses were extracted in SPM for each participant and each social condition (acceptance/rejection). Results: Compared with age-matched HC, patients with AN showed a significant time by group interaction of peak VS response throughout the task, with a progressive blunting of peak activation responses, accompanied by a progressive increase in baseline activity levels over time. Discussion: The results suggest an attenuated response pattern to repetitive social rejection in the VS in patients with AN, together with a difficulty in returning to baseline. The information obtained from this study will guide future, design-specific studies to further explore alterations temporal dynamics.

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