Previous SARS-CoV-2 Infection Increases B.1.1.7 Cross-Neutralization by Vaccinated Individuals

With the spread of new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there is a need to assess the protection conferred by both previous infections and current vaccination. Here we tested the neutralizing activity of infected and/or vaccinated individuals against pseudovi...

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Autores: Trinité, Benjamin, Pradenas, Edwards, Marfil, Silvia, Rovirosa, Carla, Urrea, Víctor, Tarrés-Freixas, Ferran, Ortiz, Raquel, Rodon, Jordi, Serra Gironella, Joan, Segalés, Joaquim, Guallar, Victor, Lepore, Rosalba, Izquierdo-Useros, Nuria, Trujillo, Glòria, Trapé, Jaume, González-Fernández, Carolina, Flor, Antonia, Pérez-Vidal, Rafel, Toledo, Ruth, Chamorro, Anna, Paredes, Roger, Blanco, Ignacio, Grau, Eulàlia, Massanella, Marta, Carrillo, Jorge, Clotet, Bonaventura, Blanco, Julià
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Institut de Recerca i Tecnologia Agroalimentàries (IRTA)
Repositorio:IRTA Pubpro. Open Digital Archive
OAI Identifier:oai:repositori.irta.cat:20.500.12327/1411
Acceso en línea:http://hdl.handle.net/20.500.12327/1411
https://doi.org/10.3390/v13061135
Access Level:acceso abierto
Palabra clave:619
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spelling Previous SARS-CoV-2 Infection Increases B.1.1.7 Cross-Neutralization by Vaccinated IndividualsTrinité, BenjaminPradenas, EdwardsMarfil, SilviaRovirosa, CarlaUrrea, VíctorTarrés-Freixas, FerranOrtiz, RaquelRodon, JordiSerra Gironella, JoanSegalés, JoaquimGuallar, VictorLepore, RosalbaIzquierdo-Useros, NuriaTrujillo, GlòriaTrapé, JaumeGonzález-Fernández, CarolinaFlor, AntoniaPérez-Vidal, RafelToledo, RuthChamorro, AnnaParedes, RogerBlanco, IgnacioGrau, EulàliaMassanella, MartaCarrillo, JorgeClotet, BonaventuraBlanco, Julià619With the spread of new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there is a need to assess the protection conferred by both previous infections and current vaccination. Here we tested the neutralizing activity of infected and/or vaccinated individuals against pseudoviruses expressing the spike of the original SARS-CoV-2 isolate Wuhan-Hu-1 (WH1), the D614G mutant and the B.1.1.7 variant. Our data show that parameters of natural infection (time from infection and nature of the infecting variant) determined cross-neutralization. Uninfected vaccinees showed a small reduction in neutralization against the B.1.1.7 variant compared to both the WH1 strain and the D614G mutant. Interestingly, upon vaccination, previously infected individuals developed more robust neutralizing responses against B.1.1.7, suggesting that vaccines can boost the neutralization breadth conferred by natural infection.info:eu-repo/semantics/publishedVersionMDPIProducció AnimalSanitat Animal202120212021info:eu-repo/semantics/article12application/pdfhttp://hdl.handle.net/20.500.12327/1411https://doi.org/10.3390/v13061135reponame:IRTA Pubpro. Open Digital Archiveinstname:Institut de Recerca i Tecnologia Agroalimentàries (IRTA)InglésVirusesAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.irta.cat:20.500.12327/14112026-06-16T08:51:17Z
dc.title.none.fl_str_mv Previous SARS-CoV-2 Infection Increases B.1.1.7 Cross-Neutralization by Vaccinated Individuals
title Previous SARS-CoV-2 Infection Increases B.1.1.7 Cross-Neutralization by Vaccinated Individuals
spellingShingle Previous SARS-CoV-2 Infection Increases B.1.1.7 Cross-Neutralization by Vaccinated Individuals
Trinité, Benjamin
619
title_short Previous SARS-CoV-2 Infection Increases B.1.1.7 Cross-Neutralization by Vaccinated Individuals
title_full Previous SARS-CoV-2 Infection Increases B.1.1.7 Cross-Neutralization by Vaccinated Individuals
title_fullStr Previous SARS-CoV-2 Infection Increases B.1.1.7 Cross-Neutralization by Vaccinated Individuals
title_full_unstemmed Previous SARS-CoV-2 Infection Increases B.1.1.7 Cross-Neutralization by Vaccinated Individuals
title_sort Previous SARS-CoV-2 Infection Increases B.1.1.7 Cross-Neutralization by Vaccinated Individuals
dc.creator.none.fl_str_mv Trinité, Benjamin
Pradenas, Edwards
Marfil, Silvia
Rovirosa, Carla
Urrea, Víctor
Tarrés-Freixas, Ferran
Ortiz, Raquel
Rodon, Jordi
Serra Gironella, Joan
Segalés, Joaquim
Guallar, Victor
Lepore, Rosalba
Izquierdo-Useros, Nuria
Trujillo, Glòria
Trapé, Jaume
González-Fernández, Carolina
Flor, Antonia
Pérez-Vidal, Rafel
Toledo, Ruth
Chamorro, Anna
Paredes, Roger
Blanco, Ignacio
Grau, Eulàlia
Massanella, Marta
Carrillo, Jorge
Clotet, Bonaventura
Blanco, Julià
author Trinité, Benjamin
author_facet Trinité, Benjamin
Pradenas, Edwards
Marfil, Silvia
Rovirosa, Carla
Urrea, Víctor
Tarrés-Freixas, Ferran
Ortiz, Raquel
Rodon, Jordi
Serra Gironella, Joan
Segalés, Joaquim
Guallar, Victor
Lepore, Rosalba
Izquierdo-Useros, Nuria
Trujillo, Glòria
Trapé, Jaume
González-Fernández, Carolina
Flor, Antonia
Pérez-Vidal, Rafel
Toledo, Ruth
Chamorro, Anna
Paredes, Roger
Blanco, Ignacio
Grau, Eulàlia
Massanella, Marta
Carrillo, Jorge
Clotet, Bonaventura
Blanco, Julià
author_role author
author2 Pradenas, Edwards
Marfil, Silvia
Rovirosa, Carla
Urrea, Víctor
Tarrés-Freixas, Ferran
Ortiz, Raquel
Rodon, Jordi
Serra Gironella, Joan
Segalés, Joaquim
Guallar, Victor
Lepore, Rosalba
Izquierdo-Useros, Nuria
Trujillo, Glòria
Trapé, Jaume
González-Fernández, Carolina
Flor, Antonia
Pérez-Vidal, Rafel
Toledo, Ruth
Chamorro, Anna
Paredes, Roger
Blanco, Ignacio
Grau, Eulàlia
Massanella, Marta
Carrillo, Jorge
Clotet, Bonaventura
Blanco, Julià
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Producció Animal
Sanitat Animal
dc.subject.none.fl_str_mv 619
topic 619
description With the spread of new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there is a need to assess the protection conferred by both previous infections and current vaccination. Here we tested the neutralizing activity of infected and/or vaccinated individuals against pseudoviruses expressing the spike of the original SARS-CoV-2 isolate Wuhan-Hu-1 (WH1), the D614G mutant and the B.1.1.7 variant. Our data show that parameters of natural infection (time from infection and nature of the infecting variant) determined cross-neutralization. Uninfected vaccinees showed a small reduction in neutralization against the B.1.1.7 variant compared to both the WH1 strain and the D614G mutant. Interestingly, upon vaccination, previously infected individuals developed more robust neutralizing responses against B.1.1.7, suggesting that vaccines can boost the neutralization breadth conferred by natural infection.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12327/1411
https://doi.org/10.3390/v13061135
url http://hdl.handle.net/20.500.12327/1411
https://doi.org/10.3390/v13061135
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Viruses
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 12
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:IRTA Pubpro. Open Digital Archive
instname:Institut de Recerca i Tecnologia Agroalimentàries (IRTA)
instname_str Institut de Recerca i Tecnologia Agroalimentàries (IRTA)
reponame_str IRTA Pubpro. Open Digital Archive
collection IRTA Pubpro. Open Digital Archive
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869416784165076992
score 15,300719

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