miRNAs in the regulation of mTOR signaling and host immune responses: The case of Leishmania infections

[EN] Micro RNAs (miRNAs), as regulators of gene expression at the post-transcriptional level, can respond to/or interact with cell signaling and affect the pathogenesis of different diseases/infections. The interaction/crosstalk of miRNAs with various cellular signaling networks including mTOR (as a...

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Autores: Manzano Román, Raúl, Rashidi, Sajad, Mansouri, Reza, Ali-Hassanzadeh, Mohammad, Ghani, Esmaeel, Karimazar, Mohammadreza, Muro Álvarez, Antonio, Muro, Antonio, Nguewa, Paul, Manzano-Román, Raúl
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Universidad de Salamanca (USAL)
Repositorio:GREDOS. Repositorio Institucional de la Universidad de Salamanca
OAI Identifier:oai:gredos.usal.es:10366/160678
Acceso en línea:http://hdl.handle.net/10366/160678
Access Level:acceso abierto
Palabra clave:ARN
Leishmaniasis
Parásitos
Leishmania
Parasites
3207.12 Parasitología
2412 Inmunología
parásitos
id ES_af2a2ef05b243eab2ed3f8edebb272e3
oai_identifier_str oai:gredos.usal.es:10366/160678
network_acronym_str ES
network_name_str España
repository_id_str
spelling miRNAs in the regulation of mTOR signaling and host immune responses: The case of Leishmania infectionsManzano Román, RaúlRashidi, SajadMansouri, RezaAli-Hassanzadeh, MohammadGhani, EsmaeelKarimazar, MohammadrezaMuro Álvarez, AntonioMuro, AntonioNguewa, PaulManzano-Román, RaúlARNLeishmaniasisParásitosLeishmaniaParasites3207.12 Parasitología2412 InmunologíaparásitosLeishmania[EN] Micro RNAs (miRNAs), as regulators of gene expression at the post-transcriptional level, can respond to/or interact with cell signaling and affect the pathogenesis of different diseases/infections. The interaction/crosstalk of miRNAs with various cellular signaling networks including mTOR (as a master regulator of signaling relevant to different cellular mechanisms) might lead to the initiation, progression or restriction of certain disease processes. There are numerous studies that have identified the crosstalk between regulatory miRNA expression and the mTOR pathway (or mTOR signaling regulated by miRNAs) in different diseases which has a dual function in pathogenesis. However, the corresponding information in parasitic infections remains scarce. miRNAs have been suggested as specific targets for therapeutic strategies in several disorders such as parasitic infections. Thus, the targeting of miRNAs (as the modulators/regulators of mTOR) by small molecules and RNA-based therapeutics and consequently managing and modulating mTOR signaling and the downstream/related cell signaling/pathways might shed some light on the design of new therapeutic strategies against parasitic diseases, including Leishmaniasis. Accordingly, the present study attempts to highlight the importance of the crosstalk between regulatory miRNAs and mTOR signaling, and to review the relevant insights into parasitic infections by focusing specifically on Leishmania.Publicación en abierto financiada por la Universidad de Salamanca como participante en el Acuerdo Transformativo CRUE-CSIC con Elsevier, 2021-2024Elsevier202420242022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10366/160678reponame:GREDOS. Repositorio Institucional de la Universidad de Salamancainstname:Universidad de Salamanca (USAL)InglésAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:gredos.usal.es:10366/1606782026-06-07T06:28:51Z
dc.title.none.fl_str_mv miRNAs in the regulation of mTOR signaling and host immune responses: The case of Leishmania infections
title miRNAs in the regulation of mTOR signaling and host immune responses: The case of Leishmania infections
spellingShingle miRNAs in the regulation of mTOR signaling and host immune responses: The case of Leishmania infections
Manzano Román, Raúl
ARN
Leishmaniasis
Parásitos
Leishmania
Parasites
3207.12 Parasitología
2412 Inmunología
parásitos
Leishmania
title_short miRNAs in the regulation of mTOR signaling and host immune responses: The case of Leishmania infections
title_full miRNAs in the regulation of mTOR signaling and host immune responses: The case of Leishmania infections
title_fullStr miRNAs in the regulation of mTOR signaling and host immune responses: The case of Leishmania infections
title_full_unstemmed miRNAs in the regulation of mTOR signaling and host immune responses: The case of Leishmania infections
title_sort miRNAs in the regulation of mTOR signaling and host immune responses: The case of Leishmania infections
dc.creator.none.fl_str_mv Manzano Román, Raúl
Rashidi, Sajad
Mansouri, Reza
Ali-Hassanzadeh, Mohammad
Ghani, Esmaeel
Karimazar, Mohammadreza
Muro Álvarez, Antonio
Muro, Antonio
Nguewa, Paul
Manzano-Román, Raúl
author Manzano Román, Raúl
author_facet Manzano Román, Raúl
Rashidi, Sajad
Mansouri, Reza
Ali-Hassanzadeh, Mohammad
Ghani, Esmaeel
Karimazar, Mohammadreza
Muro Álvarez, Antonio
Muro, Antonio
Nguewa, Paul
Manzano-Román, Raúl
author_role author
author2 Rashidi, Sajad
Mansouri, Reza
Ali-Hassanzadeh, Mohammad
Ghani, Esmaeel
Karimazar, Mohammadreza
Muro Álvarez, Antonio
Muro, Antonio
Nguewa, Paul
Manzano-Román, Raúl
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ARN
Leishmaniasis
Parásitos
Leishmania
Parasites
3207.12 Parasitología
2412 Inmunología
parásitos
Leishmania
topic ARN
Leishmaniasis
Parásitos
Leishmania
Parasites
3207.12 Parasitología
2412 Inmunología
parásitos
Leishmania
description [EN] Micro RNAs (miRNAs), as regulators of gene expression at the post-transcriptional level, can respond to/or interact with cell signaling and affect the pathogenesis of different diseases/infections. The interaction/crosstalk of miRNAs with various cellular signaling networks including mTOR (as a master regulator of signaling relevant to different cellular mechanisms) might lead to the initiation, progression or restriction of certain disease processes. There are numerous studies that have identified the crosstalk between regulatory miRNA expression and the mTOR pathway (or mTOR signaling regulated by miRNAs) in different diseases which has a dual function in pathogenesis. However, the corresponding information in parasitic infections remains scarce. miRNAs have been suggested as specific targets for therapeutic strategies in several disorders such as parasitic infections. Thus, the targeting of miRNAs (as the modulators/regulators of mTOR) by small molecules and RNA-based therapeutics and consequently managing and modulating mTOR signaling and the downstream/related cell signaling/pathways might shed some light on the design of new therapeutic strategies against parasitic diseases, including Leishmaniasis. Accordingly, the present study attempts to highlight the importance of the crosstalk between regulatory miRNAs and mTOR signaling, and to review the relevant insights into parasitic infections by focusing specifically on Leishmania.
publishDate 2022
dc.date.none.fl_str_mv 2022
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10366/160678
url http://hdl.handle.net/10366/160678
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:GREDOS. Repositorio Institucional de la Universidad de Salamanca
instname:Universidad de Salamanca (USAL)
instname_str Universidad de Salamanca (USAL)
reponame_str GREDOS. Repositorio Institucional de la Universidad de Salamanca
collection GREDOS. Repositorio Institucional de la Universidad de Salamanca
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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