Non-invasive electromechanical assessment during atrial fibrillation identifies underlying atrial myopathy alterations with early prognostic value.
Electromechanical characterization during atrial fibrillation (AF) remains a significant gap in the understanding of AF-related atrial myopathy. This study reports mechanistic insights into the electromechanical remodeling process associated with AF progression and further demonstrates its prognosti...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Instituto de Salud Carlos III (ISCIII) |
| Repositorio: | Repisalud |
| Idioma: | inglés |
| OAI Identifier: | oai:repisalud.isciii.es:20.500.12105/16393 |
| Acceso en línea: | http://hdl.handle.net/20.500.12105/16393 |
| Access Level: | acceso abierto |
| Palabra clave: | Atrial Fibrillation Atrial Remodeling Muscular Diseases Humans Animals Swine Prognosis Calcium Heart Atria |
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Non-invasive electromechanical assessment during atrial fibrillation identifies underlying atrial myopathy alterations with early prognostic value.Enríquez-Vázquez, DanielQuintanilla, Jorge GGarcía-Escolano, AlbaCouselo-Seijas, MarinelaSimón-Chica, AnaLee, PeterAlfonso-Almazan, Jose M.Mahía, PatriciaRedondo-Rodríguez, AndrésModrego, JavierOrtega-Hernández, AdrianaMarcos-Alberca, PedroMagni, RicardoCalvo, EnriqueGómez-Gordo, RubénYan, PingLa Rosa, GiulioBustamante-Madrión, JoséPérez-García, Carlos NicolásMartín-Sánchez, F JavierCalvo, Davidde la Hera, Jesús MGarcía-Torrent, María JesúsGarcía-Osuna, ÁlvaroOrdonez-Llanos, JordiVazquez, JesusPérez-Villacastín, JuliánPérez-Castellano, NicasioLoew, Leslie MSánchez-González, JavierGómez-Garre, DulcenombreFilgueiras-Rama, DavidAtrial FibrillationAtrial RemodelingMuscular DiseasesHumansAnimalsSwinePrognosisCalciumHeart AtriaElectromechanical characterization during atrial fibrillation (AF) remains a significant gap in the understanding of AF-related atrial myopathy. This study reports mechanistic insights into the electromechanical remodeling process associated with AF progression and further demonstrates its prognostic value in the clinic. In pigs, sequential electromechanical assessment during AF progression shows a progressive decrease in mechanical activity and early dissociation from its electrical counterpart. Atrial tissue samples from animals with AF reveal an abnormal increase in cardiomyocytes death and alterations in calcium handling proteins. High-throughput quantitative proteomics and immunoblotting analyses at different stages of AF progression identify downregulation of contractile proteins and progressive increase in atrial fibrosis. Moreover, advanced optical mapping techniques, applied to whole heart preparations during AF, demonstrate that AF-related remodeling decreases the frequency threshold for dissociation between transmembrane voltage signals and intracellular calcium transients compared to healthy controls. Single cell simulations of human atrial cardiomyocytes also confirm the experimental results. In patients, non-invasive assessment of the atrial electromechanical relationship further demonstrate that atrial electromechanical dissociation is an early prognostic indicator for acute and long-term rhythm control.Nature Publishing GroupUnión Europea. Comisión Europea. Horizonte EuropaMinisterio de Ciencia e Innovación (España)Instituto de Salud Carlos IIIFundación Interhospitalaria de Investigación CardiovascularFundación Salud 2000Fundación La CaixaFundación ProCNICMinisterio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)20232023-09-0420232023-08-0420232023-08-04journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/20.500.12105/16393reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/163932026-06-12T12:43:37Z |
| dc.title.none.fl_str_mv |
Non-invasive electromechanical assessment during atrial fibrillation identifies underlying atrial myopathy alterations with early prognostic value. |
| title |
Non-invasive electromechanical assessment during atrial fibrillation identifies underlying atrial myopathy alterations with early prognostic value. |
| spellingShingle |
Non-invasive electromechanical assessment during atrial fibrillation identifies underlying atrial myopathy alterations with early prognostic value. Enríquez-Vázquez, Daniel Atrial Fibrillation Atrial Remodeling Muscular Diseases Humans Animals Swine Prognosis Calcium Heart Atria |
| title_short |
Non-invasive electromechanical assessment during atrial fibrillation identifies underlying atrial myopathy alterations with early prognostic value. |
| title_full |
Non-invasive electromechanical assessment during atrial fibrillation identifies underlying atrial myopathy alterations with early prognostic value. |
| title_fullStr |
Non-invasive electromechanical assessment during atrial fibrillation identifies underlying atrial myopathy alterations with early prognostic value. |
| title_full_unstemmed |
Non-invasive electromechanical assessment during atrial fibrillation identifies underlying atrial myopathy alterations with early prognostic value. |
| title_sort |
Non-invasive electromechanical assessment during atrial fibrillation identifies underlying atrial myopathy alterations with early prognostic value. |
| dc.creator.none.fl_str_mv |
Enríquez-Vázquez, Daniel Quintanilla, Jorge G García-Escolano, Alba Couselo-Seijas, Marinela Simón-Chica, Ana Lee, Peter Alfonso-Almazan, Jose M. Mahía, Patricia Redondo-Rodríguez, Andrés Modrego, Javier Ortega-Hernández, Adriana Marcos-Alberca, Pedro Magni, Ricardo Calvo, Enrique Gómez-Gordo, Rubén Yan, Ping La Rosa, Giulio Bustamante-Madrión, José Pérez-García, Carlos Nicolás Martín-Sánchez, F Javier Calvo, David de la Hera, Jesús M García-Torrent, María Jesús García-Osuna, Álvaro Ordonez-Llanos, Jordi Vazquez, Jesus Pérez-Villacastín, Julián Pérez-Castellano, Nicasio Loew, Leslie M Sánchez-González, Javier Gómez-Garre, Dulcenombre Filgueiras-Rama, David |
| author |
Enríquez-Vázquez, Daniel |
| author_facet |
Enríquez-Vázquez, Daniel Quintanilla, Jorge G García-Escolano, Alba Couselo-Seijas, Marinela Simón-Chica, Ana Lee, Peter Alfonso-Almazan, Jose M. Mahía, Patricia Redondo-Rodríguez, Andrés Modrego, Javier Ortega-Hernández, Adriana Marcos-Alberca, Pedro Magni, Ricardo Calvo, Enrique Gómez-Gordo, Rubén Yan, Ping La Rosa, Giulio Bustamante-Madrión, José Pérez-García, Carlos Nicolás Martín-Sánchez, F Javier Calvo, David de la Hera, Jesús M García-Torrent, María Jesús García-Osuna, Álvaro Ordonez-Llanos, Jordi Vazquez, Jesus Pérez-Villacastín, Julián Pérez-Castellano, Nicasio Loew, Leslie M Sánchez-González, Javier Gómez-Garre, Dulcenombre Filgueiras-Rama, David |
| author_role |
author |
| author2 |
Quintanilla, Jorge G García-Escolano, Alba Couselo-Seijas, Marinela Simón-Chica, Ana Lee, Peter Alfonso-Almazan, Jose M. Mahía, Patricia Redondo-Rodríguez, Andrés Modrego, Javier Ortega-Hernández, Adriana Marcos-Alberca, Pedro Magni, Ricardo Calvo, Enrique Gómez-Gordo, Rubén Yan, Ping La Rosa, Giulio Bustamante-Madrión, José Pérez-García, Carlos Nicolás Martín-Sánchez, F Javier Calvo, David de la Hera, Jesús M García-Torrent, María Jesús García-Osuna, Álvaro Ordonez-Llanos, Jordi Vazquez, Jesus Pérez-Villacastín, Julián Pérez-Castellano, Nicasio Loew, Leslie M Sánchez-González, Javier Gómez-Garre, Dulcenombre Filgueiras-Rama, David |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Unión Europea. Comisión Europea. Horizonte Europa Ministerio de Ciencia e Innovación (España) Instituto de Salud Carlos III Fundación Interhospitalaria de Investigación Cardiovascular Fundación Salud 2000 Fundación La Caixa Fundación ProCNIC Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España) |
| dc.subject.none.fl_str_mv |
Atrial Fibrillation Atrial Remodeling Muscular Diseases Humans Animals Swine Prognosis Calcium Heart Atria |
| topic |
Atrial Fibrillation Atrial Remodeling Muscular Diseases Humans Animals Swine Prognosis Calcium Heart Atria |
| description |
Electromechanical characterization during atrial fibrillation (AF) remains a significant gap in the understanding of AF-related atrial myopathy. This study reports mechanistic insights into the electromechanical remodeling process associated with AF progression and further demonstrates its prognostic value in the clinic. In pigs, sequential electromechanical assessment during AF progression shows a progressive decrease in mechanical activity and early dissociation from its electrical counterpart. Atrial tissue samples from animals with AF reveal an abnormal increase in cardiomyocytes death and alterations in calcium handling proteins. High-throughput quantitative proteomics and immunoblotting analyses at different stages of AF progression identify downregulation of contractile proteins and progressive increase in atrial fibrosis. Moreover, advanced optical mapping techniques, applied to whole heart preparations during AF, demonstrate that AF-related remodeling decreases the frequency threshold for dissociation between transmembrane voltage signals and intracellular calcium transients compared to healthy controls. Single cell simulations of human atrial cardiomyocytes also confirm the experimental results. In patients, non-invasive assessment of the atrial electromechanical relationship further demonstrate that atrial electromechanical dissociation is an early prognostic indicator for acute and long-term rhythm control. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023 2023-09-04 2023 2023-08-04 2023 2023-08-04 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/20.500.12105/16393 |
| url |
http://hdl.handle.net/20.500.12105/16393 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ |
| eu_rights_str_mv |
openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
Nature Publishing Group |
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Nature Publishing Group |
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reponame:Repisalud instname:Instituto de Salud Carlos III (ISCIII) |
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Instituto de Salud Carlos III (ISCIII) |
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Repisalud |
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