Non-invasive electromechanical assessment during atrial fibrillation identifies underlying atrial myopathy alterations with early prognostic value

Electromechanical characterization during atrial fibrillation (AF) remains a significant gap in the understanding of AF-related atrial myopathy. This study reports mechanistic insights into the electromechanical remodeling process associated with AF progression and further demonstrates its prognosti...

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Detalhes bibliográficos
Autores: Enríquez-Vázquez, Daniel, Quintanilla, Jorge G.|||0000-0002-2227-3507, García-Escolano, Alba|||0000-0002-4649-4603, Couselo-Seijas, Marinela|||0000-0001-6548-477X, Simón-Chica, Ana|||0000-0002-0664-0397, Lee, Peter, Alfonso-Almazán, José Manuel, Mahía, Patricia|||0000-0002-5136-247X, Redondo-Rodríguez, Andrés|||0000-0001-7018-0711, Modrego, Javier|||0000-0002-2200-9503, Ortega-Hernández, Adriana, Marcos-Alberca, Pedro, Magni, Ricardo, Calvo, Enrique, Gómez-Gordo, Rubén, Yan, Ping, La Rosa, Giulio, Bustamante-Madrión, José, Pérez-García, Carlos Nicolás|||0000-0001-8875-9633, Martín-Sánchez, Francisco Javier|||0000-0002-5970-725X, Calvo, David, de la Hera, Jesús M., García-Torrent, María Jesús|||0000-0001-5264-608X, García Osuna, Álvaro|||0000-0002-6682-0226, Ordóñez, J. (Jordi)|||0000-0003-4896-5832, Vázquez, Jesús|||0000-0003-1461-5092, Pérez-Villacastín, Julián|||0000-0002-4867-3912, Pérez-Castellano, Nicasio, Loew, Leslie M., Sánchez González, Javier|||0000-0003-1427-3870, Gómez-Garre, Dulcenombre|||0000-0002-5056-6489, Filgueiras-Rama, David|||0000-0001-5909-2454
Formato: artículo
Fecha de publicación:2023
País:España
Recursos:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:291481
Acesso em linha:https://ddd.uab.cat/record/291481
https://dx.doi.org/urn:doi:10.1038/s41467-023-40196-y
Access Level:acceso abierto
Palavra-chave:Atrial fibrillation
Optical imaging
Descrição
Resumo:Electromechanical characterization during atrial fibrillation (AF) remains a significant gap in the understanding of AF-related atrial myopathy. This study reports mechanistic insights into the electromechanical remodeling process associated with AF progression and further demonstrates its prognostic value in the clinic. In pigs, sequential electromechanical assessment during AF progression shows a progressive decrease in mechanical activity and early dissociation from its electrical counterpart. Atrial tissue samples from animals with AF reveal an abnormal increase in cardiomyocytes death and alterations in calcium handling proteins. High-throughput quantitative proteomics and immunoblotting analyses at different stages of AF progression identify downregulation of contractile proteins and progressive increase in atrial fibrosis. Moreover, advanced optical mapping techniques, applied to whole heart preparations during AF, demonstrate that AF-related remodeling decreases the frequency threshold for dissociation between transmembrane voltage signals and intracellular calcium transients compared to healthy controls. Single cell simulations of human atrial cardiomyocytes also confirm the experimental results. In patients, non-invasive assessment of the atrial electromechanical relationship further demonstrate that atrial electromechanical dissociation is an early prognostic indicator for acute and long-term rhythm control. Electromechanical characterization during atrial fibrillation (AF) remains a significant gap in the understanding of AF-related atrial myopathy. Here, the authors use non-invasive atrial electromechanical assessment during AF to identify early remodeling changes associated with underlying myopathy, which in the clinic decrease the probability of acute and mid-term successful rhythm control.

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