Nickel-Catalyzed Site-Selective Intermolecular C(sp3)−H Amidation

A nickel-catalyzed site-selective intermolecular amidation of saturated C(sp3)–H bonds is reported. This mild protocol exhibits a predictable reactivity pattern to incorporate amide functions at C(sp3)–H sites adjacent to nitrogen and oxygen atoms in either cyclic or acyclic frameworks, thus offerin...

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Detalles Bibliográficos
Autores: Chen, Jinhong, Wang, Hao, Day, Craig S., Martin, Ruben
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2072/532804
Acceso en línea:http://hdl.handle.net/2072/532804
https://doi.org/10.1002/anie.202212983
Access Level:acceso abierto
Palabra clave:Química
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Descripción
Sumario:A nickel-catalyzed site-selective intermolecular amidation of saturated C(sp3)–H bonds is reported. This mild protocol exhibits a predictable reactivity pattern to incorporate amide functions at C(sp3)–H sites adjacent to nitrogen and oxygen atoms in either cyclic or acyclic frameworks, thus offering a complementary reactivity profile to existing oxidative-type processes or metal-catalyzed C(sp3)–N bond-forming reactions operating via two-electron manifolds.