Bioaccessibility, intestinal absorption and anti-inflammatory activity of curcuminoids incorporated in avocado, sunflower, and linseed beeswax oleogels

Beeswax oleogels (OGs), with a mechanical strength similar to pork backfat, were formulated with avocado (A), sunflower (S), and linseed (L) oils, applying a central composite design plus star point, and were evaluated as oral delivery vehicles of curcuminoids (OGACur, OGSCur, OGLCur). The incorpora...

Descripción completa

Detalles Bibliográficos
Autores: Ramírez-Carrasco, Patricia, Alemán, Ailén, González, Estefanía, Gómez Guillén, M. C., Robert, Paz, Giménez, Begoña
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/345221
Acceso en línea:http://hdl.handle.net/10261/345221
Access Level:acceso abierto
Palabra clave:Beeswax oleogels
Curcuminoids
In vitro digestion
Oxidative stability
Intestinal absorption
Anti-inflammatory properties
id ES_ae4ddd161b7e9add1f8f48aa273c8c8e
oai_identifier_str oai:digital.csic.es:10261/345221
network_acronym_str ES
network_name_str España
repository_id_str
spelling Bioaccessibility, intestinal absorption and anti-inflammatory activity of curcuminoids incorporated in avocado, sunflower, and linseed beeswax oleogelsRamírez-Carrasco, PatriciaAlemán, AilénGonzález, EstefaníaGómez Guillén, M. C.Robert, PazGiménez, BegoñaBeeswax oleogelsCurcuminoidsIn vitro digestionOxidative stabilityIntestinal absorptionAnti-inflammatory propertiesBeeswax oleogels (OGs), with a mechanical strength similar to pork backfat, were formulated with avocado (A), sunflower (S), and linseed (L) oils, applying a central composite design plus star point, and were evaluated as oral delivery vehicles of curcuminoids (OGACur, OGSCur, OGLCur). The incorporation of curcumin into the OG matrix significantly delayed both the formation of peroxides and conjugated trienes (K268 values), and the degradation rate of curcumin decreased with the increase of the oil polyunsaturated fatty acids (PUFA) content. The oil structuring did not affect the bioaccessibility of curcuminoids (>55% in all the OGs, regardless of the oil type), but it did reduce the release of fatty acids (~10%) during in vitro gastrointestinal digestion. The intestinal absorption, evaluated in Caco-2 cell monolayers, was higher for the micelle-solubilized curcumin from the digested OG than from unstructured oils, and it showed high anti-inflammatory potential by inhibiting the tumor necrosis factor-α (TNF-α) production compared to the positive control, both before and after the stimulation of ThP-1 cells with LPS. Regardless of the oil type, these beeswax-based OGs with gel-like behavior designed as fat replacers may be promising vehicles for the oral delivery of curcuminoids.This research was funded by National Research and Development Agency (ANID), Chile (Fondecyt Project 1180885, Fondecyt Project 1210909; National PhD Scholarship 21180971).Peer reviewedMultidisciplinary Digital Publishing InstituteAgencia Nacional de Investigación y Desarrollo (Chile)Fondo Nacional de Desarrollo Científico y Tecnológico (Chile)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2024202420242024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/345221reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésRamírez-Carrasco, Patricia; Alemán, Ailén; González, Estefanía; Gómez Guillén, M. C.; Robert, Paz; Giménez, Begoña; 2024; Supplementary Materials: Bioaccessibility, intestinal absorption and anti-inflammatory activity of curcuminoids incorporated in avocado, sunflower, and linseed beeswax oleogels [Dataset]; Multidisciplinary Digital Publishing Institute; https://doi.org/10.3390/foods13030373https://doi.org/10.3390/foods13030373Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3452212026-05-22T06:33:51Z
dc.title.none.fl_str_mv Bioaccessibility, intestinal absorption and anti-inflammatory activity of curcuminoids incorporated in avocado, sunflower, and linseed beeswax oleogels
title Bioaccessibility, intestinal absorption and anti-inflammatory activity of curcuminoids incorporated in avocado, sunflower, and linseed beeswax oleogels
spellingShingle Bioaccessibility, intestinal absorption and anti-inflammatory activity of curcuminoids incorporated in avocado, sunflower, and linseed beeswax oleogels
Ramírez-Carrasco, Patricia
Beeswax oleogels
Curcuminoids
In vitro digestion
Oxidative stability
Intestinal absorption
Anti-inflammatory properties
title_short Bioaccessibility, intestinal absorption and anti-inflammatory activity of curcuminoids incorporated in avocado, sunflower, and linseed beeswax oleogels
title_full Bioaccessibility, intestinal absorption and anti-inflammatory activity of curcuminoids incorporated in avocado, sunflower, and linseed beeswax oleogels
title_fullStr Bioaccessibility, intestinal absorption and anti-inflammatory activity of curcuminoids incorporated in avocado, sunflower, and linseed beeswax oleogels
title_full_unstemmed Bioaccessibility, intestinal absorption and anti-inflammatory activity of curcuminoids incorporated in avocado, sunflower, and linseed beeswax oleogels
title_sort Bioaccessibility, intestinal absorption and anti-inflammatory activity of curcuminoids incorporated in avocado, sunflower, and linseed beeswax oleogels
dc.creator.none.fl_str_mv Ramírez-Carrasco, Patricia
Alemán, Ailén
González, Estefanía
Gómez Guillén, M. C.
Robert, Paz
Giménez, Begoña
author Ramírez-Carrasco, Patricia
author_facet Ramírez-Carrasco, Patricia
Alemán, Ailén
González, Estefanía
Gómez Guillén, M. C.
Robert, Paz
Giménez, Begoña
author_role author
author2 Alemán, Ailén
González, Estefanía
Gómez Guillén, M. C.
Robert, Paz
Giménez, Begoña
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Agencia Nacional de Investigación y Desarrollo (Chile)
Fondo Nacional de Desarrollo Científico y Tecnológico (Chile)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Beeswax oleogels
Curcuminoids
In vitro digestion
Oxidative stability
Intestinal absorption
Anti-inflammatory properties
topic Beeswax oleogels
Curcuminoids
In vitro digestion
Oxidative stability
Intestinal absorption
Anti-inflammatory properties
description Beeswax oleogels (OGs), with a mechanical strength similar to pork backfat, were formulated with avocado (A), sunflower (S), and linseed (L) oils, applying a central composite design plus star point, and were evaluated as oral delivery vehicles of curcuminoids (OGACur, OGSCur, OGLCur). The incorporation of curcumin into the OG matrix significantly delayed both the formation of peroxides and conjugated trienes (K268 values), and the degradation rate of curcumin decreased with the increase of the oil polyunsaturated fatty acids (PUFA) content. The oil structuring did not affect the bioaccessibility of curcuminoids (>55% in all the OGs, regardless of the oil type), but it did reduce the release of fatty acids (~10%) during in vitro gastrointestinal digestion. The intestinal absorption, evaluated in Caco-2 cell monolayers, was higher for the micelle-solubilized curcumin from the digested OG than from unstructured oils, and it showed high anti-inflammatory potential by inhibiting the tumor necrosis factor-α (TNF-α) production compared to the positive control, both before and after the stimulation of ThP-1 cells with LPS. Regardless of the oil type, these beeswax-based OGs with gel-like behavior designed as fat replacers may be promising vehicles for the oral delivery of curcuminoids.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/345221
url http://hdl.handle.net/10261/345221
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Ramírez-Carrasco, Patricia; Alemán, Ailén; González, Estefanía; Gómez Guillén, M. C.; Robert, Paz; Giménez, Begoña; 2024; Supplementary Materials: Bioaccessibility, intestinal absorption and anti-inflammatory activity of curcuminoids incorporated in avocado, sunflower, and linseed beeswax oleogels [Dataset]; Multidisciplinary Digital Publishing Institute; https://doi.org/10.3390/foods13030373
https://doi.org/10.3390/foods13030373
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869416550684950528
score 15.812429

Similares en LA Referencia