Current Epidemiology and Outcome of Infective Endocarditis: A Multicenter, Prospective, Cohort Study

Abstract: The aim of the study was to describe the epidemiologic and clinical characteristics and identify the risk factors of short-term and 1-year mortality in a recent cohort of patients with infective endocarditis (IE). From January 2008, multidisciplinary teams have prospectively collected all...

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Autores: Muñoz, Patricia, Kestler, Martha, Alarcón, Aristides de, Miró Meda, José M. (José María), 1956-, Bermejo, Javier, Rodríguez-Abella, Hugo, Fariñas, María Carmen, Cobo Belaustegui, Manuel, Mestres Lucio, Carlos-Alberto, Llinares, Pedro, Goenaga Sánchez, Miguel Ángel, Navas Pérez, Enrique, Oteo, José Antonio, Tarabini Paola, Bouza, Emilio, Moreno Camacho, Ma. Asunción, Sitges Carreño, Marta
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/152113
Acceso en línea:https://hdl.handle.net/2445/152113
Access Level:acceso abierto
Palabra clave:Endocarditis
Epidemiologia
Malalties infeccioses
Epidemiology
Communicable diseases
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spelling Current Epidemiology and Outcome of Infective Endocarditis: A Multicenter, Prospective, Cohort StudyMuñoz, PatriciaKestler, MarthaAlarcón, Aristides deMiró Meda, José M. (José María), 1956-Bermejo, JavierRodríguez-Abella, HugoFariñas, María CarmenCobo Belaustegui, ManuelMestres Lucio, Carlos-AlbertoLlinares, PedroGoenaga Sánchez, Miguel ÁngelNavas Pérez, EnriqueOteo, José AntonioTarabini PaolaBouza, EmilioMoreno Camacho, Ma. AsunciónSitges Carreño, MartaEndocarditisEpidemiologiaMalalties infecciosesEndocarditisEpidemiologyCommunicable diseasesAbstract: The aim of the study was to describe the epidemiologic and clinical characteristics and identify the risk factors of short-term and 1-year mortality in a recent cohort of patients with infective endocarditis (IE). From January 2008, multidisciplinary teams have prospectively collected all consecutive cases of IE, diagnosed according to the Duke criteria, in 25 Spanish hospitals. Overall, 1804 patients were diagnosed. The median age was 69 years (interquartile range, 55-77), 68.0% were men, and 37.1% of the cases were nosocomial or health care-related IE. Gram-positive microorganisms accounted for 79.3% of the episodes, followed by Gram-negative (5.2%), fungi (2.4%), anaerobes (0.9%), polymicrobial infections (1.9%), and unknown etiology (9.1%). Heart surgery was performed in 44.2%, and in-hospital mortality was 28.8%. Risk factors for in-hospital mortality were age, previous heart surgery, cerebrovascular disease, atrial fibrillation, Staphylococcus or Candida etiology, intracardiac complications, heart failure, and septic shock. The 1-year independent risk factors for mortality were age (odds ratio [OR], 1.02), neoplasia (OR, 2.46), renal insufficiency (OR, 1.59), and heart failure (OR, 4.42). Surgery was an independent protective factor for 1-year mortality (OR, 0.44). IE remains a severe disease with a high rate of in-hospital (28.9%) and 1-year mortality (11.2%). Surgery was the only intervention that significantly reduced 1-year mortality.Lippincott, Williams & Wilkins. Wolters Kluwer Health2020202020152020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion8 p.application/pdfhttps://hdl.handle.net/2445/152113Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1097/MD.0000000000001816Medicine, 2015, vol. 94, num. 43, p. e1816https://doi.org/10.1097/MD.0000000000001816cc-by (c) Muñoz, Patricia et al., 2015http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1521132026-05-29T05:05:01Z
dc.title.none.fl_str_mv Current Epidemiology and Outcome of Infective Endocarditis: A Multicenter, Prospective, Cohort Study
title Current Epidemiology and Outcome of Infective Endocarditis: A Multicenter, Prospective, Cohort Study
spellingShingle Current Epidemiology and Outcome of Infective Endocarditis: A Multicenter, Prospective, Cohort Study
Muñoz, Patricia
Endocarditis
Epidemiologia
Malalties infeccioses
Endocarditis
Epidemiology
Communicable diseases
title_short Current Epidemiology and Outcome of Infective Endocarditis: A Multicenter, Prospective, Cohort Study
title_full Current Epidemiology and Outcome of Infective Endocarditis: A Multicenter, Prospective, Cohort Study
title_fullStr Current Epidemiology and Outcome of Infective Endocarditis: A Multicenter, Prospective, Cohort Study
title_full_unstemmed Current Epidemiology and Outcome of Infective Endocarditis: A Multicenter, Prospective, Cohort Study
title_sort Current Epidemiology and Outcome of Infective Endocarditis: A Multicenter, Prospective, Cohort Study
dc.creator.none.fl_str_mv Muñoz, Patricia
Kestler, Martha
Alarcón, Aristides de
Miró Meda, José M. (José María), 1956-
Bermejo, Javier
Rodríguez-Abella, Hugo
Fariñas, María Carmen
Cobo Belaustegui, Manuel
Mestres Lucio, Carlos-Alberto
Llinares, Pedro
Goenaga Sánchez, Miguel Ángel
Navas Pérez, Enrique
Oteo, José Antonio
Tarabini Paola
Bouza, Emilio
Moreno Camacho, Ma. Asunción
Sitges Carreño, Marta
author Muñoz, Patricia
author_facet Muñoz, Patricia
Kestler, Martha
Alarcón, Aristides de
Miró Meda, José M. (José María), 1956-
Bermejo, Javier
Rodríguez-Abella, Hugo
Fariñas, María Carmen
Cobo Belaustegui, Manuel
Mestres Lucio, Carlos-Alberto
Llinares, Pedro
Goenaga Sánchez, Miguel Ángel
Navas Pérez, Enrique
Oteo, José Antonio
Tarabini Paola
Bouza, Emilio
Moreno Camacho, Ma. Asunción
Sitges Carreño, Marta
author_role author
author2 Kestler, Martha
Alarcón, Aristides de
Miró Meda, José M. (José María), 1956-
Bermejo, Javier
Rodríguez-Abella, Hugo
Fariñas, María Carmen
Cobo Belaustegui, Manuel
Mestres Lucio, Carlos-Alberto
Llinares, Pedro
Goenaga Sánchez, Miguel Ángel
Navas Pérez, Enrique
Oteo, José Antonio
Tarabini Paola
Bouza, Emilio
Moreno Camacho, Ma. Asunción
Sitges Carreño, Marta
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Endocarditis
Epidemiologia
Malalties infeccioses
Endocarditis
Epidemiology
Communicable diseases
topic Endocarditis
Epidemiologia
Malalties infeccioses
Endocarditis
Epidemiology
Communicable diseases
description Abstract: The aim of the study was to describe the epidemiologic and clinical characteristics and identify the risk factors of short-term and 1-year mortality in a recent cohort of patients with infective endocarditis (IE). From January 2008, multidisciplinary teams have prospectively collected all consecutive cases of IE, diagnosed according to the Duke criteria, in 25 Spanish hospitals. Overall, 1804 patients were diagnosed. The median age was 69 years (interquartile range, 55-77), 68.0% were men, and 37.1% of the cases were nosocomial or health care-related IE. Gram-positive microorganisms accounted for 79.3% of the episodes, followed by Gram-negative (5.2%), fungi (2.4%), anaerobes (0.9%), polymicrobial infections (1.9%), and unknown etiology (9.1%). Heart surgery was performed in 44.2%, and in-hospital mortality was 28.8%. Risk factors for in-hospital mortality were age, previous heart surgery, cerebrovascular disease, atrial fibrillation, Staphylococcus or Candida etiology, intracardiac complications, heart failure, and septic shock. The 1-year independent risk factors for mortality were age (odds ratio [OR], 1.02), neoplasia (OR, 2.46), renal insufficiency (OR, 1.59), and heart failure (OR, 4.42). Surgery was an independent protective factor for 1-year mortality (OR, 0.44). IE remains a severe disease with a high rate of in-hospital (28.9%) and 1-year mortality (11.2%). Surgery was the only intervention that significantly reduced 1-year mortality.
publishDate 2015
dc.date.none.fl_str_mv 2015
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/152113
url https://hdl.handle.net/2445/152113
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1097/MD.0000000000001816
Medicine, 2015, vol. 94, num. 43, p. e1816
https://doi.org/10.1097/MD.0000000000001816
dc.rights.none.fl_str_mv cc-by (c) Muñoz, Patricia et al., 2015
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Muñoz, Patricia et al., 2015
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 8 p.
application/pdf
dc.publisher.none.fl_str_mv Lippincott, Williams & Wilkins. Wolters Kluwer Health
publisher.none.fl_str_mv Lippincott, Williams & Wilkins. Wolters Kluwer Health
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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