Current Epidemiology and Outcome of Infective Endocarditis: A Multicenter, Prospective, Cohort Study

Abstract: The aim of the study was to describe the epidemiologic and clinical characteristics and identify the risk factors of short-term and 1-year mortality in a recent cohort of patients with infective endocarditis (IE). From January 2008, multidisciplinary teams have prospectively collected all...

Descripción completa

Detalles Bibliográficos
Autores: Muñoz, Patricia, Kestler, Martha, Alarcón, Aristides de, Miró Meda, José M. (José María), 1956-, Bermejo, Javier, Rodríguez-Abella, Hugo, Fariñas, María Carmen, Cobo Belaustegui, Manuel, Mestres Lucio, Carlos-Alberto, Llinares, Pedro, Goenaga Sánchez, Miguel Ángel, Navas Pérez, Enrique, Oteo, José Antonio, Tarabini Paola, Bouza, Emilio, Moreno Camacho, Ma. Asunción, Sitges Carreño, Marta
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/152113
Acceso en línea:https://hdl.handle.net/2445/152113
Access Level:acceso abierto
Palabra clave:Endocarditis
Epidemiologia
Malalties infeccioses
Epidemiology
Communicable diseases
Descripción
Sumario:Abstract: The aim of the study was to describe the epidemiologic and clinical characteristics and identify the risk factors of short-term and 1-year mortality in a recent cohort of patients with infective endocarditis (IE). From January 2008, multidisciplinary teams have prospectively collected all consecutive cases of IE, diagnosed according to the Duke criteria, in 25 Spanish hospitals. Overall, 1804 patients were diagnosed. The median age was 69 years (interquartile range, 55-77), 68.0% were men, and 37.1% of the cases were nosocomial or health care-related IE. Gram-positive microorganisms accounted for 79.3% of the episodes, followed by Gram-negative (5.2%), fungi (2.4%), anaerobes (0.9%), polymicrobial infections (1.9%), and unknown etiology (9.1%). Heart surgery was performed in 44.2%, and in-hospital mortality was 28.8%. Risk factors for in-hospital mortality were age, previous heart surgery, cerebrovascular disease, atrial fibrillation, Staphylococcus or Candida etiology, intracardiac complications, heart failure, and septic shock. The 1-year independent risk factors for mortality were age (odds ratio [OR], 1.02), neoplasia (OR, 2.46), renal insufficiency (OR, 1.59), and heart failure (OR, 4.42). Surgery was an independent protective factor for 1-year mortality (OR, 0.44). IE remains a severe disease with a high rate of in-hospital (28.9%) and 1-year mortality (11.2%). Surgery was the only intervention that significantly reduced 1-year mortality.

Similares en LA Referencia