Thalamic Foxp2 regulates output connectivity and sensory‑motor impairments in a model of Huntington’s Disease

Here, we demonstrate in a HD mouse model a clear and early thalamo-striatal aberrant connectivity associated with a reduction of thalamic Foxp2 levels. Recovering thalamic Foxp2 levels in the mouse rescued motor coordination and sensory skills concomitant with an amelioration of neuropathological fe...

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Autores: Rodríguez Urgellés, Ened, Casas Torremocha, Diana, Sancho Balsells, Anna, Ballasch, Iván, García-García, Esther, Miquel Rio, Lluís, Manasanch, Arnau, Del Castillo, Ignacio, Chen, Wanqi, Pupak, Anika, Brito, Verónica, Tornero, Daniel, Rodríguez Allué, Manuel José, Bortolozzi Biasoni, Analía, Sánchez-Vives, María Victoria, Giralt Torroella, Albert, Alberch i Vié, Jordi, 1959-
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/207639
Acceso en línea:https://hdl.handle.net/2445/207639
Access Level:acceso abierto
Palabra clave:Corea de Huntington
Hipotàlem
Ganglis basals
Neurones sensorials
Electrofisiologia
Huntington's chorea
Hypothalamus
Basal ganglia
Sensory neurons
Electrophysiology
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spelling Thalamic Foxp2 regulates output connectivity and sensory‑motor impairments in a model of Huntington’s DiseaseRodríguez Urgellés, EnedCasas Torremocha, DianaSancho Balsells, AnnaBallasch, IvánGarcía-García, EstherMiquel Rio, LluísManasanch, ArnauDel Castillo, IgnacioChen, WanqiPupak, AnikaBrito, VerónicaTornero, DanielRodríguez Allué, Manuel JoséBortolozzi Biasoni, AnalíaSánchez-Vives, María VictoriaGiralt Torroella, AlbertAlberch i Vié, Jordi, 1959-Corea de HuntingtonHipotàlemGanglis basalsNeurones sensorialsElectrofisiologiaHuntington's choreaHypothalamusBasal gangliaSensory neuronsElectrophysiologyHere, we demonstrate in a HD mouse model a clear and early thalamo-striatal aberrant connectivity associated with a reduction of thalamic Foxp2 levels. Recovering thalamic Foxp2 levels in the mouse rescued motor coordination and sensory skills concomitant with an amelioration of neuropathological features and with a repair of the structural and functional connectivity through a restoration of neurotransmitter release. In addition, reduction of thalamic Foxp2 levels in wild type mice induced HD-like phenotypes.Springer Verlag202420232024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion25 p.application/pdfhttps://hdl.handle.net/2445/207639Articles publicats en revistes (Biomedicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1007/s00018-023-05015-zCellular and Molecular Life Sciences, 2023, vol. 80, num.12https://doi.org/10.1007/s00018-023-05015-zcc by (c) Rodríguez Urgellés, Ened et al., 2023http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2076392026-05-29T05:05:01Z
dc.title.none.fl_str_mv Thalamic Foxp2 regulates output connectivity and sensory‑motor impairments in a model of Huntington’s Disease
title Thalamic Foxp2 regulates output connectivity and sensory‑motor impairments in a model of Huntington’s Disease
spellingShingle Thalamic Foxp2 regulates output connectivity and sensory‑motor impairments in a model of Huntington’s Disease
Rodríguez Urgellés, Ened
Corea de Huntington
Hipotàlem
Ganglis basals
Neurones sensorials
Electrofisiologia
Huntington's chorea
Hypothalamus
Basal ganglia
Sensory neurons
Electrophysiology
title_short Thalamic Foxp2 regulates output connectivity and sensory‑motor impairments in a model of Huntington’s Disease
title_full Thalamic Foxp2 regulates output connectivity and sensory‑motor impairments in a model of Huntington’s Disease
title_fullStr Thalamic Foxp2 regulates output connectivity and sensory‑motor impairments in a model of Huntington’s Disease
title_full_unstemmed Thalamic Foxp2 regulates output connectivity and sensory‑motor impairments in a model of Huntington’s Disease
title_sort Thalamic Foxp2 regulates output connectivity and sensory‑motor impairments in a model of Huntington’s Disease
dc.creator.none.fl_str_mv Rodríguez Urgellés, Ened
Casas Torremocha, Diana
Sancho Balsells, Anna
Ballasch, Iván
García-García, Esther
Miquel Rio, Lluís
Manasanch, Arnau
Del Castillo, Ignacio
Chen, Wanqi
Pupak, Anika
Brito, Verónica
Tornero, Daniel
Rodríguez Allué, Manuel José
Bortolozzi Biasoni, Analía
Sánchez-Vives, María Victoria
Giralt Torroella, Albert
Alberch i Vié, Jordi, 1959-
author Rodríguez Urgellés, Ened
author_facet Rodríguez Urgellés, Ened
Casas Torremocha, Diana
Sancho Balsells, Anna
Ballasch, Iván
García-García, Esther
Miquel Rio, Lluís
Manasanch, Arnau
Del Castillo, Ignacio
Chen, Wanqi
Pupak, Anika
Brito, Verónica
Tornero, Daniel
Rodríguez Allué, Manuel José
Bortolozzi Biasoni, Analía
Sánchez-Vives, María Victoria
Giralt Torroella, Albert
Alberch i Vié, Jordi, 1959-
author_role author
author2 Casas Torremocha, Diana
Sancho Balsells, Anna
Ballasch, Iván
García-García, Esther
Miquel Rio, Lluís
Manasanch, Arnau
Del Castillo, Ignacio
Chen, Wanqi
Pupak, Anika
Brito, Verónica
Tornero, Daniel
Rodríguez Allué, Manuel José
Bortolozzi Biasoni, Analía
Sánchez-Vives, María Victoria
Giralt Torroella, Albert
Alberch i Vié, Jordi, 1959-
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Corea de Huntington
Hipotàlem
Ganglis basals
Neurones sensorials
Electrofisiologia
Huntington's chorea
Hypothalamus
Basal ganglia
Sensory neurons
Electrophysiology
topic Corea de Huntington
Hipotàlem
Ganglis basals
Neurones sensorials
Electrofisiologia
Huntington's chorea
Hypothalamus
Basal ganglia
Sensory neurons
Electrophysiology
description Here, we demonstrate in a HD mouse model a clear and early thalamo-striatal aberrant connectivity associated with a reduction of thalamic Foxp2 levels. Recovering thalamic Foxp2 levels in the mouse rescued motor coordination and sensory skills concomitant with an amelioration of neuropathological features and with a repair of the structural and functional connectivity through a restoration of neurotransmitter release. In addition, reduction of thalamic Foxp2 levels in wild type mice induced HD-like phenotypes.
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/207639
url https://hdl.handle.net/2445/207639
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1007/s00018-023-05015-z
Cellular and Molecular Life Sciences, 2023, vol. 80, num.12
https://doi.org/10.1007/s00018-023-05015-z
dc.rights.none.fl_str_mv cc by (c) Rodríguez Urgellés, Ened et al., 2023
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Rodríguez Urgellés, Ened et al., 2023
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 25 p.
application/pdf
dc.publisher.none.fl_str_mv Springer Verlag
publisher.none.fl_str_mv Springer Verlag
dc.source.none.fl_str_mv Articles publicats en revistes (Biomedicina)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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