Thalamic Foxp2 regulates output connectivity and sensory‑motor impairments in a model of Huntington’s Disease

Here, we demonstrate in a HD mouse model a clear and early thalamo-striatal aberrant connectivity associated with a reduction of thalamic Foxp2 levels. Recovering thalamic Foxp2 levels in the mouse rescued motor coordination and sensory skills concomitant with an amelioration of neuropathological fe...

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Detalhes bibliográficos
Autores: Rodríguez Urgellés, Ened, Casas Torremocha, Diana, Sancho Balsells, Anna, Ballasch, Iván, García-García, Esther, Miquel Rio, Lluís, Manasanch, Arnau, Del Castillo, Ignacio, Chen, Wanqi, Pupak, Anika, Brito, Verónica, Tornero, Daniel, Rodríguez Allué, Manuel José, Bortolozzi Biasoni, Analía, Sánchez-Vives, María Victoria, Giralt Torroella, Albert, Alberch i Vié, Jordi, 1959-
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2023
País:España
Recursos:Universidad de Barcelona
Repositório:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/207639
Acesso em linha:https://hdl.handle.net/2445/207639
Access Level:Acceso aberto
Palavra-chave:Corea de Huntington
Hipotàlem
Ganglis basals
Neurones sensorials
Electrofisiologia
Huntington's chorea
Hypothalamus
Basal ganglia
Sensory neurons
Electrophysiology
Descrição
Resumo:Here, we demonstrate in a HD mouse model a clear and early thalamo-striatal aberrant connectivity associated with a reduction of thalamic Foxp2 levels. Recovering thalamic Foxp2 levels in the mouse rescued motor coordination and sensory skills concomitant with an amelioration of neuropathological features and with a repair of the structural and functional connectivity through a restoration of neurotransmitter release. In addition, reduction of thalamic Foxp2 levels in wild type mice induced HD-like phenotypes.

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