A Metal-free Synthesis of N-Aryl Carbamates under Ambient Conditions
<p> <span style="color: rgb(51, 51, 51); font-family: 'Open Sans', Arial, Helvetica, 'Lucida Sans Unicode', sans-serif; font-size: 16px; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 24px; orphans: auto; text-ali...
| Autores: | , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2015 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2072/305762 |
| Acceso en línea: | http://hdl.handle.net/2072/305762 https://doi.org/10.1002/anie.201504956 |
| Access Level: | acceso abierto |
| Palabra clave: | Carbon dioxide N-aryl carbamates organic carbonates organocatalysis site-specificity |
| Sumario: | <p> <span style="color: rgb(51, 51, 51); font-family: 'Open Sans', Arial, Helvetica, 'Lucida Sans Unicode', sans-serif; font-size: 16px; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 24px; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: 1; word-spacing: 0px; -webkit-text-stroke-width: 0px; display: inline !important; float: none; background-color: rgb(249, 249, 249);">The first chemo- and site-selective process for the formation of N-aryl-carbamates from cyclic organic carbonates and aromatic amines is reported. The reactions proceed smoothly under extremely mild reaction conditions using TBD (triazabicyclodecene) as an effective and cheap organocatalyst, thus providing a sustainable and new methodology for the formation of a wide variety of useful N-aryl carbamate synthons in good to excellent yields. Computational investigations have been performed and show the underlying reason for the observed unique reactivity as related to an effective proton-relay mechanism mediated by the bicyclic guanidine base.</span></p> |
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