Biometry and volumetry in multi-centric fetal brain magnetic resonance imaging: assessing the bias of super-resolution reconstruction

Background: Fetal brain MRI is increasingly used to complement ultrasound imaging. Images are processed using complex super-resolution reconstruction pipelines, which may bias biometric and volumetric measurements. Objective: To assess the consistency of 2-dimensional (D) biometric and 3-D volumetri...

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Autores: Sanchez, Thomas, Mihailov, Angeline, Koob, Mériam, Girard, Nadine, Manchon, Aurélie, Valenzuela, Ignacio, Gómez-Chiari, Marta, Martí Juan, Gerard, Pron, Alexandre, Eixarch, Elisenda, Piella Fenoy, Gemma, González Ballester, Miguel Ángel, 1973-, Camara, Oscar, Dunet, Vincent, Auzias, Guillaume, Bach Cuadra, Meritxell
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/71591
Acceso en línea:http://hdl.handle.net/10230/71591
http://dx.doi.org/10.1007/s00247-025-06347-7
Access Level:acceso abierto
Palabra clave:Bias
Biometry
Fetal brain MRI
Reproducibility
Super-resolution reconstruction
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spelling Biometry and volumetry in multi-centric fetal brain magnetic resonance imaging: assessing the bias of super-resolution reconstructionSanchez, ThomasMihailov, AngelineKoob, MériamGirard, NadineManchon, AurélieValenzuela, IgnacioGómez-Chiari, MartaMartí Juan, GerardPron, AlexandreEixarch, ElisendaPiella Fenoy, GemmaGonzález Ballester, Miguel Ángel, 1973-Camara, OscarDunet, VincentAuzias, GuillaumeBach Cuadra, MeritxellBiasBiometryFetal brain MRIReproducibilitySuper-resolution reconstructionBackground: Fetal brain MRI is increasingly used to complement ultrasound imaging. Images are processed using complex super-resolution reconstruction pipelines, which may bias biometric and volumetric measurements. Objective: To assess the consistency of 2-dimensional (D) biometric and 3-D volumetric measurements across three hospitals using three widely used super-resolution reconstruction pipelines. Materials and methods: This retrospective multi-centric study used T2-weighted fetal brain MRI scans acquired at three hospitals between 2009 and 2023. MRIs from each subject were reconstructed with each super-resolution reconstruction method, and biometric measurements were performed by four experts. Automated 3-D volumetry was performed using a state-of-the-art segmentation method. A qualitative evaluation assessed the clinicians’ likelihood of using super-resolution reconstructed volumes in their practice. Results: Eighty-four healthy subjects were included. Biometric measurements revealed statistically significant changes that consistently remained below voxel width (0.8 mm; P<0.001). Automated 3-D volumetry revealed small systematic effects (<2.8%; P<0.001). The qualitative evaluation showed systematic differences between super-resolution reconstruction methods for the perception of white matter intensity (P=0.02) and sharpness of the image (P=0.01). Conclusion: Variations in 2-D and 3-D quantitative measurements did not show any large systematic bias when using different super-resolution reconstruction methods for clinical radiological assessment across centers, scanners, and raters.Nature Research202520252025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/71591http://dx.doi.org/10.1007/s00247-025-06347-7http://hdl.handle.net/10230/71591reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésPediatric Radiology. 2025 Aug 8;55(10):2064-75This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/715912026-05-29T05:05:01Z
dc.title.none.fl_str_mv Biometry and volumetry in multi-centric fetal brain magnetic resonance imaging: assessing the bias of super-resolution reconstruction
title Biometry and volumetry in multi-centric fetal brain magnetic resonance imaging: assessing the bias of super-resolution reconstruction
spellingShingle Biometry and volumetry in multi-centric fetal brain magnetic resonance imaging: assessing the bias of super-resolution reconstruction
Sanchez, Thomas
Bias
Biometry
Fetal brain MRI
Reproducibility
Super-resolution reconstruction
title_short Biometry and volumetry in multi-centric fetal brain magnetic resonance imaging: assessing the bias of super-resolution reconstruction
title_full Biometry and volumetry in multi-centric fetal brain magnetic resonance imaging: assessing the bias of super-resolution reconstruction
title_fullStr Biometry and volumetry in multi-centric fetal brain magnetic resonance imaging: assessing the bias of super-resolution reconstruction
title_full_unstemmed Biometry and volumetry in multi-centric fetal brain magnetic resonance imaging: assessing the bias of super-resolution reconstruction
title_sort Biometry and volumetry in multi-centric fetal brain magnetic resonance imaging: assessing the bias of super-resolution reconstruction
dc.creator.none.fl_str_mv Sanchez, Thomas
Mihailov, Angeline
Koob, Mériam
Girard, Nadine
Manchon, Aurélie
Valenzuela, Ignacio
Gómez-Chiari, Marta
Martí Juan, Gerard
Pron, Alexandre
Eixarch, Elisenda
Piella Fenoy, Gemma
González Ballester, Miguel Ángel, 1973-
Camara, Oscar
Dunet, Vincent
Auzias, Guillaume
Bach Cuadra, Meritxell
author Sanchez, Thomas
author_facet Sanchez, Thomas
Mihailov, Angeline
Koob, Mériam
Girard, Nadine
Manchon, Aurélie
Valenzuela, Ignacio
Gómez-Chiari, Marta
Martí Juan, Gerard
Pron, Alexandre
Eixarch, Elisenda
Piella Fenoy, Gemma
González Ballester, Miguel Ángel, 1973-
Camara, Oscar
Dunet, Vincent
Auzias, Guillaume
Bach Cuadra, Meritxell
author_role author
author2 Mihailov, Angeline
Koob, Mériam
Girard, Nadine
Manchon, Aurélie
Valenzuela, Ignacio
Gómez-Chiari, Marta
Martí Juan, Gerard
Pron, Alexandre
Eixarch, Elisenda
Piella Fenoy, Gemma
González Ballester, Miguel Ángel, 1973-
Camara, Oscar
Dunet, Vincent
Auzias, Guillaume
Bach Cuadra, Meritxell
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Bias
Biometry
Fetal brain MRI
Reproducibility
Super-resolution reconstruction
topic Bias
Biometry
Fetal brain MRI
Reproducibility
Super-resolution reconstruction
description Background: Fetal brain MRI is increasingly used to complement ultrasound imaging. Images are processed using complex super-resolution reconstruction pipelines, which may bias biometric and volumetric measurements. Objective: To assess the consistency of 2-dimensional (D) biometric and 3-D volumetric measurements across three hospitals using three widely used super-resolution reconstruction pipelines. Materials and methods: This retrospective multi-centric study used T2-weighted fetal brain MRI scans acquired at three hospitals between 2009 and 2023. MRIs from each subject were reconstructed with each super-resolution reconstruction method, and biometric measurements were performed by four experts. Automated 3-D volumetry was performed using a state-of-the-art segmentation method. A qualitative evaluation assessed the clinicians’ likelihood of using super-resolution reconstructed volumes in their practice. Results: Eighty-four healthy subjects were included. Biometric measurements revealed statistically significant changes that consistently remained below voxel width (0.8 mm; P<0.001). Automated 3-D volumetry revealed small systematic effects (<2.8%; P<0.001). The qualitative evaluation showed systematic differences between super-resolution reconstruction methods for the perception of white matter intensity (P=0.02) and sharpness of the image (P=0.01). Conclusion: Variations in 2-D and 3-D quantitative measurements did not show any large systematic bias when using different super-resolution reconstruction methods for clinical radiological assessment across centers, scanners, and raters.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/71591
http://dx.doi.org/10.1007/s00247-025-06347-7
http://hdl.handle.net/10230/71591
url http://hdl.handle.net/10230/71591
http://dx.doi.org/10.1007/s00247-025-06347-7
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Pediatric Radiology. 2025 Aug 8;55(10):2064-75
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Research
publisher.none.fl_str_mv Nature Research
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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