Intestinal epithelial cell response to Endoplasmic Reticulum stress in Inflammatory Bowel Disease
Inflammatory Bowel Disease (IBD), including Crohn's disease (CD) and Ulcerative colitis (UC), is characterized by a chronic relapsing intestinal inflammation. Although its etiology remains unknown, it involves complex interactions between the immune response and genetic, environmental or microb...
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| Tipo de recurso: | tesis doctoral |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Universidad Complutense de Madrid (UCM) |
| Repositorio: | Docta Complutense |
| Idioma: | inglés |
| OAI Identifier: | oai:docta.ucm.es:20.500.14352/91003 |
| Acceso en línea: | https://hdl.handle.net/20.500.14352/91003 |
| Access Level: | acceso abierto |
| Palabra clave: | 616.34(043.2) Intestines Intestinos Medicina interna 3205 Medicina Interna |
| Sumario: | Inflammatory Bowel Disease (IBD), including Crohn's disease (CD) and Ulcerative colitis (UC), is characterized by a chronic relapsing intestinal inflammation. Although its etiology remains unknown, it involves complex interactions between the immune response and genetic, environmental or microbial factors such as Short-Chain Fatty Acids (SCFAs) which are implicated in intestinal epithelial cell (IEC) homeostasis as well as in the regulation of the gut immune system. In turn, IECs are critical for maintaining the intestinal barrier and can secrete and respond to various mediators that regulate the immune response in the gut.The Unfolded Protein Response (UPR) is a mechanism triggered by the accumulation of unfolded or misfolded proteins within the ER lumen, a condition known as Endoplasmic Reticulum (ER) stress. The UPR plays a critical role in maintaining the homeostasis of the intestinal epithelium by keeping the balance between the microbiota, IECs and the immune response. Moreover, a dysfunctional UPR may be linked to several inflammatory diseases including IBD, although the underlying mechanisms are largely unknown.The aim of the present work was to identify Unfolded Protein Response-related mechanisms that might be involved in the triggering or the perpetuation of the inflammatory response in Inflammatory Bowel Disease... |
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