The genetics of East African populations: a Nilo-Saharan component in the African genetic landscape
East Africa is a strategic region to study human genetic diversity due to the presence of ethnically, linguistically, and geographically diverse populations. Here, we provide new insight into the genetic history of populations living in the Sudanese region of East Africa by analysing nine ethnic gro...
| Autores: | , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2015 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:10230/25768 |
| Acceso en línea: | http://hdl.handle.net/10230/25768 http://dx.doi.org/10.1038/srep09996 |
| Access Level: | acceso abierto |
| Palabra clave: | Genètica de poblacions humanes -- Àfrica del Nord |
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The genetics of East African populations: a Nilo-Saharan component in the African genetic landscapeDobón Berenguer, Begoña, 1987-Hassan, Hisham Y.Laayouni, Hafid, 1968-Luisi, Pierre, 1985-Ricaño Ponce, IsisZhernakova, AlexandraWijmenga, CiscaTahir, HananComas, David, 1969-Netea, Mihai GBertranpetit, Jaume, 1952-Genètica de poblacions humanes -- Àfrica del NordEast Africa is a strategic region to study human genetic diversity due to the presence of ethnically, linguistically, and geographically diverse populations. Here, we provide new insight into the genetic history of populations living in the Sudanese region of East Africa by analysing nine ethnic groups belonging to three African linguistic families: Niger-Kordofanian, Nilo-Saharan and Afro-Asiatic. A total of 500 individuals were genotyped for 200,000 single-nucleotide polymorphisms. Principal component analysis, clustering analysis using ADMIXTURE, FST statistics, and the three-population test were used to investigate the underlying genetic structure and ancestry of the different ethno-linguistic groups. Our analyses revealed a genetic component for Sudanese Nilo-Saharan speaking groups (Darfurians and part of Nuba populations) related to Nilotes of South Sudan, but not to other Sudanese populations or other sub-Saharan populations. Populations inhabiting the North of the region showed close genetic affinities with North Africa, with a component that could be remnant of North Africans before the migrations of Arabs from Arabia. In addition, we found very low genetic distances between populations in genes important for anti-malarial and anti-bacterial host defence, suggesting similar selective pressures on these genes and stressing the importance of considering functional pathways to understand the evolutionary history of populations.M.G.N. was supported by a Vici Grant of the Netherlands Organization for Scientific Research, and an ERC Consolidator Grant (nr. 310372). J.B. was supported by grant BFU2013-43726-P awarded by Ministerio de Economía y Competitividad (Spain) and with the support of Secretaria d’Universitats i Recerca del Departament d’Economia i Coneixement de la Generalitat de Catalunya (GRC 2014 SGR 866). B.D. is supported by F.P.U. grant FPU13/06813 from the Ministerio de Educación, Cultura y Deporte (Spain). C.W. is supported by the European Research Council under the European Union’s Seventh Frame-work Programme (FP/2007-2013)/ERC Grant Agreement [n. 2012-322698]. A.Z. holds a Rosalind Franklin fellowship from the University of Groningen. We thank the National Institute of Bioinformatics (http://www.inab.org) for computational support.Nature Publishing Group201620162015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/25768http://dx.doi.org/10.1038/srep09996reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésScientific Reports. 2015;5:9996http://hdl.handle.net/10230/34507info:eu-repo/grantAgreement/ES/1PE/BFU2013-43726-P© Nature Publishing Group. http://www.nature.com/articles/srep09996/nThis work is licensed under a Creative Commons Attribution 4.0 International License.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/257682026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
The genetics of East African populations: a Nilo-Saharan component in the African genetic landscape |
| title |
The genetics of East African populations: a Nilo-Saharan component in the African genetic landscape |
| spellingShingle |
The genetics of East African populations: a Nilo-Saharan component in the African genetic landscape Dobón Berenguer, Begoña, 1987- Genètica de poblacions humanes -- Àfrica del Nord |
| title_short |
The genetics of East African populations: a Nilo-Saharan component in the African genetic landscape |
| title_full |
The genetics of East African populations: a Nilo-Saharan component in the African genetic landscape |
| title_fullStr |
The genetics of East African populations: a Nilo-Saharan component in the African genetic landscape |
| title_full_unstemmed |
The genetics of East African populations: a Nilo-Saharan component in the African genetic landscape |
| title_sort |
The genetics of East African populations: a Nilo-Saharan component in the African genetic landscape |
| dc.creator.none.fl_str_mv |
Dobón Berenguer, Begoña, 1987- Hassan, Hisham Y. Laayouni, Hafid, 1968- Luisi, Pierre, 1985- Ricaño Ponce, Isis Zhernakova, Alexandra Wijmenga, Cisca Tahir, Hanan Comas, David, 1969- Netea, Mihai G Bertranpetit, Jaume, 1952- |
| author |
Dobón Berenguer, Begoña, 1987- |
| author_facet |
Dobón Berenguer, Begoña, 1987- Hassan, Hisham Y. Laayouni, Hafid, 1968- Luisi, Pierre, 1985- Ricaño Ponce, Isis Zhernakova, Alexandra Wijmenga, Cisca Tahir, Hanan Comas, David, 1969- Netea, Mihai G Bertranpetit, Jaume, 1952- |
| author_role |
author |
| author2 |
Hassan, Hisham Y. Laayouni, Hafid, 1968- Luisi, Pierre, 1985- Ricaño Ponce, Isis Zhernakova, Alexandra Wijmenga, Cisca Tahir, Hanan Comas, David, 1969- Netea, Mihai G Bertranpetit, Jaume, 1952- |
| author2_role |
author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Genètica de poblacions humanes -- Àfrica del Nord |
| topic |
Genètica de poblacions humanes -- Àfrica del Nord |
| description |
East Africa is a strategic region to study human genetic diversity due to the presence of ethnically, linguistically, and geographically diverse populations. Here, we provide new insight into the genetic history of populations living in the Sudanese region of East Africa by analysing nine ethnic groups belonging to three African linguistic families: Niger-Kordofanian, Nilo-Saharan and Afro-Asiatic. A total of 500 individuals were genotyped for 200,000 single-nucleotide polymorphisms. Principal component analysis, clustering analysis using ADMIXTURE, FST statistics, and the three-population test were used to investigate the underlying genetic structure and ancestry of the different ethno-linguistic groups. Our analyses revealed a genetic component for Sudanese Nilo-Saharan speaking groups (Darfurians and part of Nuba populations) related to Nilotes of South Sudan, but not to other Sudanese populations or other sub-Saharan populations. Populations inhabiting the North of the region showed close genetic affinities with North Africa, with a component that could be remnant of North Africans before the migrations of Arabs from Arabia. In addition, we found very low genetic distances between populations in genes important for anti-malarial and anti-bacterial host defence, suggesting similar selective pressures on these genes and stressing the importance of considering functional pathways to understand the evolutionary history of populations. |
| publishDate |
2015 |
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2015 2016 2016 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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http://hdl.handle.net/10230/25768 http://dx.doi.org/10.1038/srep09996 |
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http://hdl.handle.net/10230/25768 http://dx.doi.org/10.1038/srep09996 |
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Inglés |
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Inglés |
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Scientific Reports. 2015;5:9996 http://hdl.handle.net/10230/34507 info:eu-repo/grantAgreement/ES/1PE/BFU2013-43726-P |
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http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf application/pdf |
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Nature Publishing Group |
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Nature Publishing Group |
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reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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