Immunohistochemical evaluation of the cellular immune response to Rickettsia conorii in taches noires
[EN]Significant infiltration by inflammatory cells, mainly lymphocytes and macrophages, was observed in and around blood vessels within the taches noires of patients with Mediterranean sopotted fever (MSF). Rickettsia conorii antigens were found in the endothelium (lining of blood vessels) and withi...
| Autores: | , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 1987 |
| País: | España |
| Institución: | Universidad de Salamanca (USAL) |
| Repositorio: | GREDOS. Repositorio Institucional de la Universidad de Salamanca |
| OAI Identifier: | oai:gredos.usal.es:10366/169219 |
| Acceso en línea: | http://hdl.handle.net/10366/169219 |
| Access Level: | acceso embargado |
| Palabra clave: | Rickettsia conorii infection Mediterranean soptted fever Boutonneuse fever Tache noire Cellullar immune response B-Lymphocytes Macrophages T-Lymphocytes Rickettsia Boutonneuse Fever Humans Immunity 32 Ciencias Médicas humanos macrófagos linfocitos B linfocitos T fiebre botonosa inmunidad |
| Sumario: | [EN]Significant infiltration by inflammatory cells, mainly lymphocytes and macrophages, was observed in and around blood vessels within the taches noires of patients with Mediterranean sopotted fever (MSF). Rickettsia conorii antigens were found in the endothelium (lining of blood vessels) and within these inflammatory cells, showing the primary site of infection and immune attack.This cellular response, involving T-cells and macrophages, is vital for eliminating infected cells and controlling the bacteria, but the associated inflammation also contributes to the characteristic vascular injury (vasculitis) seen in MSF. Immunohistochemistry proved effective in detecting rickettsial antigens in skin biopsies, confirming infection during the acute phase, complementing other diagnostic methods like PCR and serology. |
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