Integrated miRNA and mRNA expression profiling identifies novel targets and pathological mechanisms in autoimmune thyroid diseases

[Background] The mechanisms underlying autoimmune thyroid disease (AITD) remain elusive. Identification of such mechanisms would reveal novel and/or better therapeutic targets. Here, we use integrated analysis of miRNAs and mRNAs expression profiling to identify potential therapeutic targets involve...

Descripción completa

Detalles Bibliográficos
Autores: Martínez-Hernández, Rebeca, Serrano-Somavilla, Ana, Ramos-Leví, Ana, Sampedro-Nuñez, Miguel, Lens-Pardo, Alberto, Muñoz De Nova, José Luis, Triviño, Juan Carlos, González Sagardoy, María Ujué, Torné, Lorena, Casares-Arias, Javier, Martín-Cófreces, Noa Beatriz, Sánchez-Madrid, Francisco, Marazuela, Mónica
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/197715
Acceso en línea:http://hdl.handle.net/10261/197715
Access Level:acceso abierto
Palabra clave:microRNAs
mRNA
Next generation sequencing
Autoimmune thyroid disease
Graves’ disease
Hashimoto's thyroiditis
Cilia
Descripción
Sumario:[Background] The mechanisms underlying autoimmune thyroid disease (AITD) remain elusive. Identification of such mechanisms would reveal novel and/or better therapeutic targets. Here, we use integrated analysis of miRNAs and mRNAs expression profiling to identify potential therapeutic targets involved in the mechanisms underlying AITD.

Similares en LA Referencia