A cross-sectional study of seroprevalence of strongyloidiasis in pregnant women (peruvian Amazon basin)
Strongyloidiasis is a soil-transmitted helminthiasis with a high global prevalence. Objectives: We aimed to evaluate the prevalence of Strongyloides stercoralis infection and assess strongyloidiasis serology as a screening technique in the Peruvian Amazon. Material and Methods: We performed a cross-...
| Autores: | , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2020 |
| País: | España |
| Institución: | Universidad Autónoma de Madrid |
| Repositorio: | Biblos-e Archivo. Repositorio Institucional de la UAM |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.uam.es:10486/693262 |
| Acceso en línea: | http://hdl.handle.net/10486/693262 https://dx.doi.org/10.3390/pathogens9050348 |
| Access Level: | acceso abierto |
| Palabra clave: | Strongyloides stercoralis Serology Seroprevalence Prevalence Peru Amazon Medicina |
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A cross-sectional study of seroprevalence of strongyloidiasis in pregnant women (peruvian Amazon basin)Ortiz-Martínez, SoniaRamos-Rincón, José-ManuelVásquez-Chasnamote, María-EsteynerAlarcón-Baldeón, Jhonatan J.Parraguez-de-la-Cruz, JorgeGamboa-Paredes, Olga-NoheliaSchillyk-Guerra, PatriciaEspinoza-Venegas, Luis-AlfredoPinedo-Cancino, Viviana-VanessaPerez-Tanoira, RamónGórgolas Hernández-Mora, MiguelCasapía-Morales, MartínSpanish-Peruvian ChagasHTLVStrongyloides NetworkStrongyloides stercoralisSerologySeroprevalencePrevalencePeruAmazonMedicinaStrongyloidiasis is a soil-transmitted helminthiasis with a high global prevalence. Objectives: We aimed to evaluate the prevalence of Strongyloides stercoralis infection and assess strongyloidiasis serology as a screening technique in the Peruvian Amazon. Material and Methods: We performed a cross-sectional study of strongyloidiasis in 300 pregnant women in Iquitos (Peru) from 1 May 2019 to 15 June 2019. Women were tested using serology (Strongyloides IgG IVD-ELISA kit) as an index test and the modified Baermann technique and/or charcoal fecal culture as the parasitological reference standard. Results: The reference tests showed S. stercoralis in the stool of 30 women (prevalence: 10%; 95% confidence interval [CI] 7.1% to 13.9%), while 101 women tested positive on the blood test (prevalence: 33.7%; 95% CI 28.6% to 39.4%). Fourteen of the 15 women (93.3%) with positive results according to the modified Baermann technique, and 14 of the 23 women (56.5%) with positive charcoal cultures also had positive serological results. Serology showed a sensitivity of 63.3% and a negative predictive value of 94.4%. Conclusion: In Iquitos, pregnant women have a high prevalence of S stercoralis. S. stercoralis ELISA could be an excellent tool for population-based screening, as it has a high negative predictive value that can help to rule out the presence of active infectionThis research was co-funded by the University Development Cooperation Program, Miguel Hernández University of Elche and Generalitat Valenciana. Grant number [SOLCIF/2017/0005]MDPI, Basel, SwitzerlandDepartamento de MedicinaFacultad de MedicinaInstituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD)20202020-05-04research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/693262https://dx.doi.org/10.3390/pathogens9050348reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/6932622026-06-23T12:46:27Z |
| dc.title.none.fl_str_mv |
A cross-sectional study of seroprevalence of strongyloidiasis in pregnant women (peruvian Amazon basin) |
| title |
A cross-sectional study of seroprevalence of strongyloidiasis in pregnant women (peruvian Amazon basin) |
| spellingShingle |
A cross-sectional study of seroprevalence of strongyloidiasis in pregnant women (peruvian Amazon basin) Ortiz-Martínez, Sonia Strongyloides stercoralis Serology Seroprevalence Prevalence Peru Amazon Medicina |
| title_short |
A cross-sectional study of seroprevalence of strongyloidiasis in pregnant women (peruvian Amazon basin) |
| title_full |
A cross-sectional study of seroprevalence of strongyloidiasis in pregnant women (peruvian Amazon basin) |
| title_fullStr |
A cross-sectional study of seroprevalence of strongyloidiasis in pregnant women (peruvian Amazon basin) |
| title_full_unstemmed |
A cross-sectional study of seroprevalence of strongyloidiasis in pregnant women (peruvian Amazon basin) |
| title_sort |
A cross-sectional study of seroprevalence of strongyloidiasis in pregnant women (peruvian Amazon basin) |
| dc.creator.none.fl_str_mv |
Ortiz-Martínez, Sonia Ramos-Rincón, José-Manuel Vásquez-Chasnamote, María-Esteyner Alarcón-Baldeón, Jhonatan J. Parraguez-de-la-Cruz, Jorge Gamboa-Paredes, Olga-Nohelia Schillyk-Guerra, Patricia Espinoza-Venegas, Luis-Alfredo Pinedo-Cancino, Viviana-Vanessa Perez-Tanoira, Ramón Górgolas Hernández-Mora, Miguel Casapía-Morales, Martín Spanish-Peruvian Chagas HTLV Strongyloides Network |
| author |
Ortiz-Martínez, Sonia |
| author_facet |
Ortiz-Martínez, Sonia Ramos-Rincón, José-Manuel Vásquez-Chasnamote, María-Esteyner Alarcón-Baldeón, Jhonatan J. Parraguez-de-la-Cruz, Jorge Gamboa-Paredes, Olga-Nohelia Schillyk-Guerra, Patricia Espinoza-Venegas, Luis-Alfredo Pinedo-Cancino, Viviana-Vanessa Perez-Tanoira, Ramón Górgolas Hernández-Mora, Miguel Casapía-Morales, Martín Spanish-Peruvian Chagas HTLV Strongyloides Network |
| author_role |
author |
| author2 |
Ramos-Rincón, José-Manuel Vásquez-Chasnamote, María-Esteyner Alarcón-Baldeón, Jhonatan J. Parraguez-de-la-Cruz, Jorge Gamboa-Paredes, Olga-Nohelia Schillyk-Guerra, Patricia Espinoza-Venegas, Luis-Alfredo Pinedo-Cancino, Viviana-Vanessa Perez-Tanoira, Ramón Górgolas Hernández-Mora, Miguel Casapía-Morales, Martín Spanish-Peruvian Chagas HTLV Strongyloides Network |
| author2_role |
author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Departamento de Medicina Facultad de Medicina Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD) |
| dc.subject.none.fl_str_mv |
Strongyloides stercoralis Serology Seroprevalence Prevalence Peru Amazon Medicina |
| topic |
Strongyloides stercoralis Serology Seroprevalence Prevalence Peru Amazon Medicina |
| description |
Strongyloidiasis is a soil-transmitted helminthiasis with a high global prevalence. Objectives: We aimed to evaluate the prevalence of Strongyloides stercoralis infection and assess strongyloidiasis serology as a screening technique in the Peruvian Amazon. Material and Methods: We performed a cross-sectional study of strongyloidiasis in 300 pregnant women in Iquitos (Peru) from 1 May 2019 to 15 June 2019. Women were tested using serology (Strongyloides IgG IVD-ELISA kit) as an index test and the modified Baermann technique and/or charcoal fecal culture as the parasitological reference standard. Results: The reference tests showed S. stercoralis in the stool of 30 women (prevalence: 10%; 95% confidence interval [CI] 7.1% to 13.9%), while 101 women tested positive on the blood test (prevalence: 33.7%; 95% CI 28.6% to 39.4%). Fourteen of the 15 women (93.3%) with positive results according to the modified Baermann technique, and 14 of the 23 women (56.5%) with positive charcoal cultures also had positive serological results. Serology showed a sensitivity of 63.3% and a negative predictive value of 94.4%. Conclusion: In Iquitos, pregnant women have a high prevalence of S stercoralis. S. stercoralis ELISA could be an excellent tool for population-based screening, as it has a high negative predictive value that can help to rule out the presence of active infection |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020 2020-05-04 |
| dc.type.none.fl_str_mv |
research article http://purl.org/coar/resource_type/c_2df8fbb1 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10486/693262 https://dx.doi.org/10.3390/pathogens9050348 |
| url |
http://hdl.handle.net/10486/693262 https://dx.doi.org/10.3390/pathogens9050348 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
MDPI, Basel, Switzerland |
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MDPI, Basel, Switzerland |
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reponame:Biblos-e Archivo. Repositorio Institucional de la UAM instname:Universidad Autónoma de Madrid |
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Universidad Autónoma de Madrid |
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Biblos-e Archivo. Repositorio Institucional de la UAM |
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Biblos-e Archivo. Repositorio Institucional de la UAM |
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