A Cross-Sectional Study of Seroprevalence of Strongyloidiasis in Pregnant Women (Peruvian Amazon Basin)

Strongyloidiasis is a soil-transmitted helminthiasis with a high global prevalence. Objectives: We aimed to evaluate the prevalence of Strongyloides stercoralis infection and assess strongyloidiasis serology as a screening technique in the Peruvian Amazon. Material and Methods: We performed a cross-...

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Detalhes bibliográficos
Autores: Ortiz-Martinez, S, Ramos-Rincon, JM, Vasquez-Chasnamote, ME, Alarcon-Baldeon, JJ, Parraguez-de-la-Cruz, J, Gamboa-Paredes, ON, Schillyk-Guerra, P, Espinoza-Venegas, LA, Pinedo-Cancino, VV, Perez-Tanoira, R, Gorgolas-Hernandez-Mora, M, Casapia-Morales, M, Ramos-Rincon, M, Gimeno, A, Llenas-Garcia, J, Prieto, L, Alarcon-Baldeon, JPDLCJJ, Bardales-Vasquez, J, Perez-Bardales, G, Silva, AHVTZ, Pezo-Flores, RP, Cancino, VVP, Morales, MC, Spanish-Peruvian Chagas HTLV Stron
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Recursos:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p9122
Acesso em linha:https://fisabio.portalinvestigacion.com/publicaciones/9122
Access Level:acceso abierto
Palavra-chave:Strongyloides stercoralis
serology
seroprevalence
prevalence
Peru
Amazon
Descrição
Resumo:Strongyloidiasis is a soil-transmitted helminthiasis with a high global prevalence. Objectives: We aimed to evaluate the prevalence of Strongyloides stercoralis infection and assess strongyloidiasis serology as a screening technique in the Peruvian Amazon. Material and Methods: We performed a cross-sectional study of strongyloidiasis in 300 pregnant women in Iquitos (Peru) from 1 May 2019 to 15 June 2019. Women were tested using serology (Strongyloides IgG IVD-ELISA kit) as an index test and the modified Baermann technique and/or charcoal fecal culture as the parasitological reference standard. Results: The reference tests showed S. stercoralis in the stool of 30 women (prevalence: 10%; 95% confidence interval [CI] 7.1% to 13.9%), while 101 women tested positive on the blood test (prevalence: 33.7%; 95% CI 28.6% to 39.4%). Fourteen of the 15 women (93.3%) with positive results according to the modified Baermann technique, and 14 of the 23 women (56.5%) with positive charcoal cultures also had positive serological results. Serology showed a sensitivity of 63.3% and a negative predictive value of 94.4%. Conclusion: In Iquitos, pregnant women have a high prevalence of S stercoralis. S. stercoralis ELISA could be an excellent tool for population-based screening, as it has a high negative predictive value that can help to rule out the presence of active infection.

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