Characteristics of subjective cognitive decline associated with amyloid positivity

Introduction: The evidence for characteristics of persons with subjective cognitive decline (SCD) associated with amyloid positivity is limited. Methods: In 1640 persons with SCD from 20 Amyloid Biomarker Study cohort, we investigated the associations of SCD-specific characteristics (informant confi...

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Autores: Janssen, Olin|||0000-0002-8341-0958, Jansen, Willemijn J., Vos, Stephanie J.B.|||0000-0002-2045-9818, Boada, Mercè|||0000-0003-2617-3009, Parnetti, Lucilla|||0000-0001-5722-3967, Gabryelewicz, Tomasz, Fladby, Tormod|||0000-0002-9984-9797, Molinuevo, José Luis|||0000-0003-0485-6001, Villeneuve, Sylvia, Hort, Jakub|||0000-0002-1080-3726, Epelbaum, Stéphane, Lleó, Alberto|||0000-0002-2568-5478, Engelborghs, Sebastiaan|||0000-0003-0304-9785, van der Flier, Wiesje M.|||0000-0001-8766-6224, Landau, Susan, Popp, Julius|||0000-0002-0068-0312, Wallin, Anders|||0000-0001-9506-0513, Scheltens, Philip|||0000-0002-1046-6408, Rikkert, Marcel Olde|||0000-0003-1397-1677, Snyder, Peter J.|||0000-0003-0555-4654, Rowe, Chris, Chételat, G.|||0000-0002-4889-7932, Ruiz Laza, Agustín|||0000-0003-2633-2495, Marquié, Marta|||0000-0002-0660-0950, Chipi, Elena, Wolfsgruber, Steffen, Heneka, Michael|||0000-0003-4996-1630, Boecker, Henning|||0000-0003-2346-0598, Peters, Oliver|||0000-0003-0568-2998, Jarholm, Jonas, Rami Gonzalez, Lorena|||0000-0002-7411-1921, Tort-Merino, Adrià|||0000-0002-5646-0482, Pichet Binette, Alexa|||0000-0001-5218-3337, Poirier, Judes, Rosa-Neto, Pedro|||0000-0001-9116-1376, Cerman, Jiri, Dubois, Bruno, Teichmann, Marc, Alcolea, Daniel|||0000-0002-3819-3245, Fortea, Juan|||0000-0002-1340-638X, Sánchez-Saudinós, María Belén|||0000-0003-1795-1833, Ebenau, Jarith, Pocnet, Cornelia, Eckerström, Marie, Thompson, Louisa, Villemagne, Victor, Buckley, Rachel|||0000-0002-5356-5537, Burnham, Samantha, Delarue, Marion, Freund-Levi, Yvonne|||0000-0001-6863-6679, Wallin, Åsa K., Ramakers, Inez, Tsolaki, Magda|||0000-0002-2072-8010, Soininen, Hilkka|||0000-0002-2785-9937, Hampel, Harald, Spiru, Luiza, Tijms, Betty M.|||0000-0002-2612-1797, Ossenkoppele, Rik, Verhey, Frans, Jessen, Frank, Visser, Pieter Jelle|||0000-0001-8008-9727
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:282309
Acceso en línea:https://ddd.uab.cat/record/282309
https://dx.doi.org/urn:doi:10.1002/alz.12512
Access Level:acceso abierto
Palabra clave:Alzheimer's disease
Amyloid
Cerebrospinal fluid
Positron emission tomography
Subjective cognitive decline
Descripción
Sumario:Introduction: The evidence for characteristics of persons with subjective cognitive decline (SCD) associated with amyloid positivity is limited. Methods: In 1640 persons with SCD from 20 Amyloid Biomarker Study cohort, we investigated the associations of SCD-specific characteristics (informant confirmation, domain-specific complaints, concerns, feelings of worse performance) demographics, setting, apolipoprotein E gene (APOE) ε4 carriership, and neuropsychiatric symptoms with amyloid positivity. Results: Between cohorts, amyloid positivity in 70-year-olds varied from 10% to 76%. Only older age, clinical setting, and APOE ε4 carriership showed univariate associations with increased amyloid positivity. After adjusting for these, lower education was also associated with increased amyloid positivity. Only within a research setting, informant-confirmed complaints, memory complaints, attention/concentration complaints, and no depressive symptoms were associated with increased amyloid positivity. Feelings of worse performance were associated with less amyloid positivity at younger ages and more at older ages. Discussion: Next to age, setting, and APOE ε4 carriership, SCD-specific characteristics may facilitate the identification of amyloid-positive individuals.

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