Associations of lifestyle factors with amyloid pathology in persons without dementia

Background: The association between lifestyle factors and Alzheimer's disease (AD) pathophysiology remains incompletely understood. Objective: The aim of this study was to assess the association of alcohol consumption, smoking behavior, sleep quality and physical, cognitive, and social activity...

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Detalhes bibliográficos
Autores: Oomens, JE, Vos, SJB, Maserejian, NN, Boada, M, Didic, M, Engelborghs, S, Fladby, T, van der Flier, WM, Frisoni, GB, Fröhlich, L, Gill, KD, Grimmer, T, Hort, J, Itoh, Y, Iwatsubo, T, Klimkowicz-Mrowiec, A, Landau, SM, Lee, DY, Lleó, A, Martinez-Lage, P, de Mendonça, A, Meyer, PT, Parchi, P, Pardini, M, Parnetti, L, Popp, J, Rami, L, Reiman, EM, Rinne, JO, Rodrigue, KM, Sánchez-Juan, P, Santana, I, Scarmeas, N, Scheltens, P, Skoog, I, Sperling, RA, Stern, Y, Villeneuve, S, Waldemar, G, Wiltfang, J, Zetterberg, H, Alcolea, D, Allegri, RF, Altomare, D, Bateman, RJ, Baiardi, S, Baldeiras, I, Blennow, K, den Braber, A, van Buchem, MA, Byun, MS, Cerman, J, Chen, KW, Chipi, E, Day, GS, Drzezga, A, Ekblad, LL, Förster, S, Fortea, J, Freund-Levi, Y, Frings, L, Guedj, E, Habeck, CG, Handels, R, Hausner, L, Hellwig, S, Jiménez-Bonilla, JF, Juaristi, AI, Kandimalla, R, Kern, S, Kirsebom, BESB, Kornhuber, J, Legdeur, N, Levin, J, Maier, W, Marquié, M, Minatani, S, Morbelli, SD, Mroczko, B, Ntanasi, E, de Oliveira, CR, Orellana, A, Peters, O, Prabhakar, S, Ramakers, IH, Rodríguez-Rodriguez, E, Ruiz, A, Rüther, E, Sakhardande, J, Selnes, P, Silva, D, Soininen, H, Spiru, L, Takeda, A, Teunissen, CE, Tijms, BM, Vermunt, L, Wallin, ÅK, Wiels, W, Yannakoulia, M, Yi, D, Zettergren, A, Ossenkoppele, R, Verhey, FRJ, Visser, PJ, Jansen, WJ
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Recursos:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p20809
Acesso em linha:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=20809
Access Level:acceso abierto
Palavra-chave:Alzheimer's disease
amyloid
amyloid biomarker study
cerebrospinal fluid
positron emission tomography
lifestyle
Descrição
Resumo:Background: The association between lifestyle factors and Alzheimer's disease (AD) pathophysiology remains incompletely understood. Objective: The aim of this study was to assess the association of alcohol consumption, smoking behavior, sleep quality and physical, cognitive, and social activity with cerebral amyloid pathology. Methods: For this cross-sectional study, we selected participants from the Amyloid Biomarker Study data pooling initiative. We used generalized estimating equations to assess associations of dichotomized lifestyle measures with amyloid pathology. Results: We included 9171 participants with normal cognition (NC) and 2555 participants with mild cognitive impairment (MCI) from the Amyloid Biomarker Study. Of participants with NC, 58% were women, 34% were APOE epsilon 4 carrier, and 27% had amyloid pathology. Of participants with MCI, 48% were women, 47% were APOE epsilon 4 carrier, and 57% had amyloid pathology. In NC, cognitively active participants were less likely to have amyloid pathology (OR = 0.77, 95%CI 0.66 - 0.89, p < 0.001). In MCI, participants who had ever smoked or had sleep problems were less likely to have amyloid pathology (OR = 0.85, 95%CI 0.73-0.99, p = 0.029; OR = 0.62, 95%CI 0.45-0.86, p = 0.004). Conclusions: In NC, cognitive activity was associated with a lower frequency of amyloid pathology. In MCI, favorable lifestyle behaviors were not associated with a lower frequency of amyloid pathology. The results of the current study contribute to the broader evidence base on lifestyle and AD by further characterizing the role of lifestyle behaviors in AD pathology across different clinical stages.

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