Nosocomial Transmission of SARS-CoV-2 Involving Vaccinated Health Care Workers

COVID-19 vaccination has proven to be effective at preventing symptomatic disease but there are scarce data to fully understand whether vaccinated individuals can still behave as SARS-CoV-2 transmission vectors. Based on viral genome sequencing and detailed epidemiological interviews, we report a no...

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Detalles Bibliográficos
Autores: Pérez-Lago, Laura, Machado, Marina, Gómez-Ruiz, María de Mar, Sola-Campoy, Pedro J., Buenestado-Serrano, Sergio, de la Cueva-García, Victor Manuel, López Herranz, Marta, Andrés Zayas, Cristina, Sánchez-Arcilla, Ignacio, Flores-García, Rubén Francisco, López Fresneña, María Nieves, García de San José, Sonia, Catalán Alonso, Pilar, Muñoz García, Patricia Carmen, García de Viedma, Darío
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/120013
Acceso en línea:https://hdl.handle.net/20.500.14352/120013
Access Level:acceso abierto
Palabra clave:61
COVID-19
SARS-CoV-2
Transmission
Vaccination
Nosocomial
Genomics
Ciencias Biomédicas
3299 Otras Especialidades Médicas
Descripción
Sumario:COVID-19 vaccination has proven to be effective at preventing symptomatic disease but there are scarce data to fully understand whether vaccinated individuals can still behave as SARS-CoV-2 transmission vectors. Based on viral genome sequencing and detailed epidemiological interviews, we report a nosocomial transmission event involving two vaccinated health care-workers (HCWs) and four patients, one of them with fatal outcome. Strict transmission control measures, as during the prevaccination period, must be kept between HCWs and HCWs-patients in nosocomial settings. IMPORTANCE COVID-19 vaccination has proven to be effective at preventing symptomatic disease. Although some transmission events involving vaccinated cases have also been reported, scarce information is still available to fully understand whether vaccinated individuals may still behave as vectors in SARS-CoV-2 transmission events. Here, we report a SARS-CoV-2 nosocomial transmission event, supported on whole genome sequencing, in early March 2021 involving two vaccinated HCWs and four patients in our institution. Strict transmission control measures between HCWs and HCWs - patients in nosocomial settings must not be relaxed, and should be kept as strictly as during the prevaccination period.

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