Skin autofluorescence–indicated advanced glycation end products as predictors of cardiovascular and all-cause mortality in high-risk subjects: A systematic review and meta-analysis

Background Chronic deposits of advanced glycation end products produced by enzymatic glycation have been suggested as predictors of atherosclerotic-related disorders. This study aimed to estimate the relationship between advanced glycation end products indicated by skin autofluorescence levels and t...

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Autores: Cavero Redondo, Iván, Soriano Cano, Alba, Álvarez Bueno, Celia, Cunha, Pedro G., Martínez Hortelano, José Alberto, Garrido Miguel, Miriam, Berlanga Macías, Carlos, Martínez Vizcaíno, Vicente José Anastasio
Tipo de documento: artigo
Data de publicação:2018
País:España
Recursos:Fundación Dialnet. Universidad de La Rioja
Repositório:RUIdeRA. Repositorio Institucional de la UCLM
OAI Identifier:oai:ruidera.uclm.es:10578/47671
Acesso em linha:https://www.ahajournals.org/doi/full/10.1161/JAHA.118.009833
https://hdl.handle.net/10578/47671
Access Level:Acceso aberto
Palavra-chave:Advanced glycation end products
Cardiovascular complications
Meta-analysis
Mortality
Skin autofluorescence
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spelling Skin autofluorescence–indicated advanced glycation end products as predictors of cardiovascular and all-cause mortality in high-risk subjects: A systematic review and meta-analysisCavero Redondo, IvánSoriano Cano, AlbaÁlvarez Bueno, CeliaCunha, Pedro G.Martínez Hortelano, José AlbertoGarrido Miguel, MiriamBerlanga Macías, CarlosMartínez Vizcaíno, Vicente José AnastasioAdvanced glycation end productsCardiovascular complicationsMeta-analysisMortalitySkin autofluorescenceBackground Chronic deposits of advanced glycation end products produced by enzymatic glycation have been suggested as predictors of atherosclerotic-related disorders. This study aimed to estimate the relationship between advanced glycation end products indicated by skin autofluorescence levels and the risk of cardiovascular and all-cause mortality based on data from observational studies. Methods and Results We systematically searched Medline, Embase, the Cochrane Central Register of Controlled Trials, the Cochrane Database of Systematic Reviews, and the Web of Science databases from their inceptions until November 2017 for observational studies addressing the association of advanced glycation end products by skin autofluorescence levels with cardiovascular and all-cause mortality. The DerSimonian and Laird random-effects method was used to compute pooled estimates of hazard ratios and their respective 95% confidence intervals for the risk of cardiovascular and all-cause mortality associated with levels of advanced glycation end products by skin autofluorescence. Ten published studies were included in the systematic review and meta-analysis. Higher skin autofluorescence levels were significantly associated with a higher pooled risk estimate for cardiovascular mortality (hazard ratio: 2.06; 95% confidence interval, 1.58–2.67), which might not be important to moderate heterogeneity (I2=34.7%; P=0.163), and for all-cause mortality (hazard ratio: 1.91; 95% confidence interval, 1.42–2.56) with substantial heterogeneity (I2=60.8%; P=0.0.18). Conclusions Our data suggest that skin autofluorescence levels could be considered predictors of all-cause mortality and cardiovascular mortality in patients at high and very high riskAmerican Heart Association202620262018info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://www.ahajournals.org/doi/full/10.1161/JAHA.118.009833https://hdl.handle.net/10578/47671reponame:RUIdeRA. Repositorio Institucional de la UCLMinstname:Fundación Dialnet. Universidad de La RiojaInglésFPU13/01582PREDUCLM16/14Spanish Ministry of Economy, Industry, and Competitiveness (Fi 17/332)FPU15/03847FPU16/02380info:eu-repo/semantics/openAccessoai:ruidera.uclm.es:10578/476712026-05-27T07:36:41Z
dc.title.none.fl_str_mv Skin autofluorescence–indicated advanced glycation end products as predictors of cardiovascular and all-cause mortality in high-risk subjects: A systematic review and meta-analysis
title Skin autofluorescence–indicated advanced glycation end products as predictors of cardiovascular and all-cause mortality in high-risk subjects: A systematic review and meta-analysis
spellingShingle Skin autofluorescence–indicated advanced glycation end products as predictors of cardiovascular and all-cause mortality in high-risk subjects: A systematic review and meta-analysis
Cavero Redondo, Iván
Advanced glycation end products
Cardiovascular complications
Meta-analysis
Mortality
Skin autofluorescence
title_short Skin autofluorescence–indicated advanced glycation end products as predictors of cardiovascular and all-cause mortality in high-risk subjects: A systematic review and meta-analysis
title_full Skin autofluorescence–indicated advanced glycation end products as predictors of cardiovascular and all-cause mortality in high-risk subjects: A systematic review and meta-analysis
title_fullStr Skin autofluorescence–indicated advanced glycation end products as predictors of cardiovascular and all-cause mortality in high-risk subjects: A systematic review and meta-analysis
title_full_unstemmed Skin autofluorescence–indicated advanced glycation end products as predictors of cardiovascular and all-cause mortality in high-risk subjects: A systematic review and meta-analysis
title_sort Skin autofluorescence–indicated advanced glycation end products as predictors of cardiovascular and all-cause mortality in high-risk subjects: A systematic review and meta-analysis
dc.creator.none.fl_str_mv Cavero Redondo, Iván
Soriano Cano, Alba
Álvarez Bueno, Celia
Cunha, Pedro G.
Martínez Hortelano, José Alberto
Garrido Miguel, Miriam
Berlanga Macías, Carlos
Martínez Vizcaíno, Vicente José Anastasio
author Cavero Redondo, Iván
author_facet Cavero Redondo, Iván
Soriano Cano, Alba
Álvarez Bueno, Celia
Cunha, Pedro G.
Martínez Hortelano, José Alberto
Garrido Miguel, Miriam
Berlanga Macías, Carlos
Martínez Vizcaíno, Vicente José Anastasio
author_role author
author2 Soriano Cano, Alba
Álvarez Bueno, Celia
Cunha, Pedro G.
Martínez Hortelano, José Alberto
Garrido Miguel, Miriam
Berlanga Macías, Carlos
Martínez Vizcaíno, Vicente José Anastasio
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Advanced glycation end products
Cardiovascular complications
Meta-analysis
Mortality
Skin autofluorescence
topic Advanced glycation end products
Cardiovascular complications
Meta-analysis
Mortality
Skin autofluorescence
description Background Chronic deposits of advanced glycation end products produced by enzymatic glycation have been suggested as predictors of atherosclerotic-related disorders. This study aimed to estimate the relationship between advanced glycation end products indicated by skin autofluorescence levels and the risk of cardiovascular and all-cause mortality based on data from observational studies. Methods and Results We systematically searched Medline, Embase, the Cochrane Central Register of Controlled Trials, the Cochrane Database of Systematic Reviews, and the Web of Science databases from their inceptions until November 2017 for observational studies addressing the association of advanced glycation end products by skin autofluorescence levels with cardiovascular and all-cause mortality. The DerSimonian and Laird random-effects method was used to compute pooled estimates of hazard ratios and their respective 95% confidence intervals for the risk of cardiovascular and all-cause mortality associated with levels of advanced glycation end products by skin autofluorescence. Ten published studies were included in the systematic review and meta-analysis. Higher skin autofluorescence levels were significantly associated with a higher pooled risk estimate for cardiovascular mortality (hazard ratio: 2.06; 95% confidence interval, 1.58–2.67), which might not be important to moderate heterogeneity (I2=34.7%; P=0.163), and for all-cause mortality (hazard ratio: 1.91; 95% confidence interval, 1.42–2.56) with substantial heterogeneity (I2=60.8%; P=0.0.18). Conclusions Our data suggest that skin autofluorescence levels could be considered predictors of all-cause mortality and cardiovascular mortality in patients at high and very high risk
publishDate 2018
dc.date.none.fl_str_mv 2018
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://www.ahajournals.org/doi/full/10.1161/JAHA.118.009833
https://hdl.handle.net/10578/47671
url https://www.ahajournals.org/doi/full/10.1161/JAHA.118.009833
https://hdl.handle.net/10578/47671
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv FPU13/01582
PREDUCLM16/14
Spanish Ministry of Economy, Industry, and Competitiveness (Fi 17/332)
FPU15/03847
FPU16/02380
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Heart Association
publisher.none.fl_str_mv American Heart Association
dc.source.none.fl_str_mv reponame:RUIdeRA. Repositorio Institucional de la UCLM
instname:Fundación Dialnet. Universidad de La Rioja
instname_str Fundación Dialnet. Universidad de La Rioja
reponame_str RUIdeRA. Repositorio Institucional de la UCLM
collection RUIdeRA. Repositorio Institucional de la UCLM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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