Skin Autofluorescence Measurement in Subclinical Atheromatous Disease

Aim: Advanced glycation end-products (AGEs) have been involved in the atherogenic process in the high-risk population. The goal of this study was to demonstrate that AGEs are related to subclinical atheromatous disease in subjects with low to moderate vascular risk. Methods: A cross-sectional study...

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Autores: Sánchez, Enric|||0000-0001-7345-1601, Betriu, Àngels|||0000-0002-0290-4586, Yeramian, Andree, Fernández, Elvira|||0000-0001-5236-1762, Purroy, Francesc, Sánchez de la Torre, Manuel|||0000-0002-5695-348X, Pamplona, Reinald|||0000-0003-4337-6107, Miquel, Eva, Kerkeni, Mohsen|||0000-0001-5594-7451, Hernández, Cristina|||0000-0002-3109-1721, Simó Canonge, Rafael|||0000-0003-0475-3096, Lecube, Albert|||0000-0001-9684-0183, Hernández García, Marta|||0000-0003-1237-298X, Rius, Ferran, Polanco, Dinora, Barbé, Ferran|||0000-0002-2340-8928, Torres, Gerard|||0000-0002-1417-7320, Suárez, Guillermo, Portero-Otin, Manuel, Jové, Mariona|||0000-0001-5577-6162, Colàs-Campàs, Laura, Benabdelhak, Ikram, Farràs-Sallés, Cristina|||0000-0001-5956-4116, Ortega, Marta, Valdivielso, José Manuel|||0000-0003-1343-0184, Bermúdez-López, Marcelino|||0000-0002-3188-4158, Martínez-Alonso, Montse
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:226382
Acceso en línea:https://ddd.uab.cat/record/226382
https://dx.doi.org/urn:doi:10.5551/jat.47498
Access Level:acceso abierto
Palabra clave:Advanced glycation end-products
Atheromatous plaque burden
Cardiovascular risk
Skin autofluorescence
Descripción
Sumario:Aim: Advanced glycation end-products (AGEs) have been involved in the atherogenic process in the high-risk population. The goal of this study was to demonstrate that AGEs are related to subclinical atheromatous disease in subjects with low to moderate vascular risk. Methods: A cross-sectional study in which 2,568 non-diabetic subjects of both sexes without cardiovascular disease were included. Subcutaneous content of AGEs was assessed by skin autofluorescence (SAF) and subclinical atheromatous disease was measured by assessing the atheromatous plaque burden in carotid and femoral regions using ultrasonography. In addition, serum pentosidine, carboxymethyl-lysine (CML) and AGE receptors (RAGE) were assessed in a nested case-control study with 41 subjects without plaque and 41 individuals subjects with generalized disease. Results: Patients with atheromatous plaque had a higher SAF than those with no plaque (1.9 [1.7 to 2.3] vs. 1.8 [1.6 to 2.1] arbitrary units (AU), p % 0.001). The SAF correlated with the total number of affected regions (r = 0.171, p < 0.001), increasing progressively from 1.8 [1.6 to 2.1] AU in those without atheromatous disease to 2.3 [1.9 to 2.7] AU in patients with ≥ 8 plaques (p < 0.001). A correlation was also observed between SAF and the total plaque area (r = 0.113, p < 0.001). The area under the Receiver Operating Characteristic curve was 0.65 (0.61 to 0.68) for identifying male subjects with atheromatous disease. The multivariable logistic regression model showed a significant and independent association between SAF and the presence of atheromatous disease. However, no significant differences in serum pentosidine, CML, and RAGE were observed. Conclusions: Increased subcutaneous content of AGEs is associated with augmented atheromatous plaque burden. Our results suggest that SAF may provide clinically relevant information to the current strategies for the evaluation of cardiovascular risk, especially among the male population.

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