Intervention effects of greenspace exposure on human microbiota: A randomized controlled trial in Chinese young adults
Enriching human microbiota has been proposed as a mechanism by which greenspace exposure improves human health. The existing evidence is scarce with few studies able to evaluate causality. We conducted a randomized controlled trial of 30 healthy undergraduate students to explore the intervention eff...
| Autores: | , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:10230/70711 |
| Acceso en línea: | http://hdl.handle.net/10230/70711 http://dx.doi.org/10.1016/j.ecoenv.2025.118183 |
| Access Level: | acceso abierto |
| Palabra clave: | Greenspace Gut microbiota Human microbiota Natural environment Oral microbiota |
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Intervention effects of greenspace exposure on human microbiota: A randomized controlled trial in Chinese young adultsWang, LuLi, Jun-YiZhu, Xiao-QiJiang, Jian-ChengLi, ChuangZheng, Zi-HanWang, ZhiZhao, TianyuMarkevych, IanaHeinrich, JoachimDadvand, PayamBrowing, Matthew H. E. M.Chen, ChenHuang, Ji-LinDong, Guang-HuiYang, Bo-YiGreenspaceGut microbiotaHuman microbiotaNatural environmentOral microbiotaEnriching human microbiota has been proposed as a mechanism by which greenspace exposure improves human health. The existing evidence is scarce with few studies able to evaluate causality. We conducted a randomized controlled trial of 30 healthy undergraduate students to explore the intervention effects of greenspace on human gut and oral microbiota alpha-diversity, composition, differential genera and functional pathways. The study participants were divided into three groups, including outdoor greenspace (GS) group, outdoor non-greenspace (NGS) group, and indoor group, who visited a park, an open space without vegetation, and a classroom, respectively, for two hours per day over seven days. Differences in microbial alpha-diversity and composition across various groups were tested using Wilcoxon test and permutational multivariate analysis of variance, respectively. Linear discriminant analysis effect size analysis was performed to test differences in genera and functional pathways. Greenspace intervention significantly increased gut microbiota alpha-diversity, especially the observed Amplicon Sequence variant indexes and the Faith indexes (both p < 0.05). In addition, the intervention substantially changed the composition of gut microbiota, of which the relative abundances of potentially beneficial bacteria increased. Further, the greenspace intervention affected several functional pathways of gut microbiota, including "substance dependence", "specific types of cancer", and "viral infectious diseases". However, we did not find any significant effect of greenspace intervention on oral microbiota. Our results suggest that greenspace intervention diversifies the gut microbiota and alters its composition. These findings could help to reinforce the potential of increasing people's access to greenspace as a public health intervention.Elsevier202520252025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/70711http://dx.doi.org/10.1016/j.ecoenv.2025.118183http://hdl.handle.net/10230/70711reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésEcotoxicol Environ Saf. 2025 May;296:118183© 2025 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/707112026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Intervention effects of greenspace exposure on human microbiota: A randomized controlled trial in Chinese young adults |
| title |
Intervention effects of greenspace exposure on human microbiota: A randomized controlled trial in Chinese young adults |
| spellingShingle |
Intervention effects of greenspace exposure on human microbiota: A randomized controlled trial in Chinese young adults Wang, Lu Greenspace Gut microbiota Human microbiota Natural environment Oral microbiota |
| title_short |
Intervention effects of greenspace exposure on human microbiota: A randomized controlled trial in Chinese young adults |
| title_full |
Intervention effects of greenspace exposure on human microbiota: A randomized controlled trial in Chinese young adults |
| title_fullStr |
Intervention effects of greenspace exposure on human microbiota: A randomized controlled trial in Chinese young adults |
| title_full_unstemmed |
Intervention effects of greenspace exposure on human microbiota: A randomized controlled trial in Chinese young adults |
| title_sort |
Intervention effects of greenspace exposure on human microbiota: A randomized controlled trial in Chinese young adults |
| dc.creator.none.fl_str_mv |
Wang, Lu Li, Jun-Yi Zhu, Xiao-Qi Jiang, Jian-Cheng Li, Chuang Zheng, Zi-Han Wang, Zhi Zhao, Tianyu Markevych, Iana Heinrich, Joachim Dadvand, Payam Browing, Matthew H. E. M. Chen, Chen Huang, Ji-Lin Dong, Guang-Hui Yang, Bo-Yi |
| author |
Wang, Lu |
| author_facet |
Wang, Lu Li, Jun-Yi Zhu, Xiao-Qi Jiang, Jian-Cheng Li, Chuang Zheng, Zi-Han Wang, Zhi Zhao, Tianyu Markevych, Iana Heinrich, Joachim Dadvand, Payam Browing, Matthew H. E. M. Chen, Chen Huang, Ji-Lin Dong, Guang-Hui Yang, Bo-Yi |
| author_role |
author |
| author2 |
Li, Jun-Yi Zhu, Xiao-Qi Jiang, Jian-Cheng Li, Chuang Zheng, Zi-Han Wang, Zhi Zhao, Tianyu Markevych, Iana Heinrich, Joachim Dadvand, Payam Browing, Matthew H. E. M. Chen, Chen Huang, Ji-Lin Dong, Guang-Hui Yang, Bo-Yi |
| author2_role |
author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Greenspace Gut microbiota Human microbiota Natural environment Oral microbiota |
| topic |
Greenspace Gut microbiota Human microbiota Natural environment Oral microbiota |
| description |
Enriching human microbiota has been proposed as a mechanism by which greenspace exposure improves human health. The existing evidence is scarce with few studies able to evaluate causality. We conducted a randomized controlled trial of 30 healthy undergraduate students to explore the intervention effects of greenspace on human gut and oral microbiota alpha-diversity, composition, differential genera and functional pathways. The study participants were divided into three groups, including outdoor greenspace (GS) group, outdoor non-greenspace (NGS) group, and indoor group, who visited a park, an open space without vegetation, and a classroom, respectively, for two hours per day over seven days. Differences in microbial alpha-diversity and composition across various groups were tested using Wilcoxon test and permutational multivariate analysis of variance, respectively. Linear discriminant analysis effect size analysis was performed to test differences in genera and functional pathways. Greenspace intervention significantly increased gut microbiota alpha-diversity, especially the observed Amplicon Sequence variant indexes and the Faith indexes (both p < 0.05). In addition, the intervention substantially changed the composition of gut microbiota, of which the relative abundances of potentially beneficial bacteria increased. Further, the greenspace intervention affected several functional pathways of gut microbiota, including "substance dependence", "specific types of cancer", and "viral infectious diseases". However, we did not find any significant effect of greenspace intervention on oral microbiota. Our results suggest that greenspace intervention diversifies the gut microbiota and alters its composition. These findings could help to reinforce the potential of increasing people's access to greenspace as a public health intervention. |
| publishDate |
2025 |
| dc.date.none.fl_str_mv |
2025 2025 2025 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10230/70711 http://dx.doi.org/10.1016/j.ecoenv.2025.118183 http://hdl.handle.net/10230/70711 |
| url |
http://hdl.handle.net/10230/70711 http://dx.doi.org/10.1016/j.ecoenv.2025.118183 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Ecotoxicol Environ Saf. 2025 May;296:118183 |
| dc.rights.none.fl_str_mv |
http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
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application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
Elsevier |
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Elsevier |
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reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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