Human respiratory syncytial virus infects and induces activation markers in mouse B lymphocytes
Human respiratory syncytial virus (HRSV) is the most common cause of severe respiratory infections in infants and young children, often leading to hospitalization. Although human airway epithelial cells are the main target of HRSV, it has been reported that this virus can also infect professional an...
| Authors: | , , , , , , |
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| Format: | article |
| Publication Date: | 2009 |
| Country: | España |
| Institution: | Instituto de Salud Carlos III (ISCIII) |
| Repository: | Repisalud |
| Language: | English |
| OAI Identifier: | oai:repisalud.isciii.es:20.500.12105/10654 |
| Online Access: | http://hdl.handle.net/20.500.12105/10654 |
| Access Level: | Open access |
| Keyword: | Animals B-Lymphocytes Biomarkers CD4-Positive T-Lymphocytes CD8-Positive T-Lymphocytes Glycosaminoglycans Histocompatibility Antigens Class I Histocompatibility Antigens Class II Lymphocyte Activation Mice Mice, Inbred C57BL Respiratory Syncytial Virus Infections Respiratory Syncytial Virus, Human |
| Summary: | Human respiratory syncytial virus (HRSV) is the most common cause of severe respiratory infections in infants and young children, often leading to hospitalization. Although human airway epithelial cells are the main target of HRSV, it has been reported that this virus can also infect professional antigen-presenting cells such as macrophages and dendritic cells, promoting upregulation of maturation markers. Here, we report that mouse spleen B220(+) B lymphocytes were susceptible to HRSV infection in vitro, probably involving a glycosaminoglycan-dependent mechanism. In contrast, neither CD4(+) nor CD8(+) T lymphocytes were infected. In B lymphocytes, HRSV infection upregulated major histocompatibility complex (MHC) class II but not MHC class I molecules and induced the expression of the activation marker CD86. |
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