Quality of Life and the Experience of Living with Early-Stage Alzheimer's Disease
Background: There is a need to better understand the experience of patients living with Alzheimer's disease (AD) in the early stages. Objective: The aim of the study was to evaluate the perception of quality of life in patients with early-stage AD. Methods: A multicenter, non-interventional stu...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:290594 |
| Acceso en línea: | https://ddd.uab.cat/record/290594 https://dx.doi.org/urn:doi:10.3233/JAD-220696 |
| Access Level: | acceso abierto |
| Palabra clave: | Alzheimer's disease Amyloid Biomarkers Cerebrospinal fluid Magnetic resonance imaging Tau proteins White matter hyperintensities White matter lesions |
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Quality of Life and the Experience of Living with Early-Stage Alzheimer's DiseaseVillarejo-Galende, Alberto|||0000-0002-6834-7620García-Arcelay, ElenaPiñol-Ripoll, GerardDel Olmo-Rodríguez, AntonioViñuela, FélixBoada, Mercè|||0000-0003-2617-3009Franco-Macías, Emilio|||0000-0003-4186-1037Ibáñez de la Peña, AlmudenaRiverol, MarioPuig-Pijoan, Albert|||0000-0002-9848-3711Abizanda-Soler, PedroArroyo, RafaelBaquero-Toledo, MiquelFeria-Vilar, InmaculadaBalasa, Mircea|||0000-0002-1795-4228Berbel, ÁngelRodríguez-Rodríguez, Eloy|||0000-0001-7742-677XVieira-Campos, AlbaGarcía-Ribas, GuillermoRodrigo-Herrero, SilviaTerrancle, ÁngelesPrefasi, DanielLleó, Alberto|||0000-0002-2568-5478Maurino, Jorge|||0000-0001-9858-3555Alzheimer's diseaseAmyloidBiomarkersCerebrospinal fluidMagnetic resonance imagingTau proteinsWhite matter hyperintensitiesWhite matter lesionsBackground: There is a need to better understand the experience of patients living with Alzheimer's disease (AD) in the early stages. Objective: The aim of the study was to evaluate the perception of quality of life in patients with early-stage AD. Methods: A multicenter, non-interventional study was conducted including patients of 50-90 years of age with prodromal or mild AD, a Mini-Mental State Examination (MMSE) score ≥22, and a Clinical Dementia Rating-Global score (CDR-GS) of 0.5.-1.0. The Quality of Life in Alzheimer 's Disease (QoL-AD) questionnaire was used to assess health-related quality of life. A battery of self-report instruments was used to evaluate different psychological and behavioral domains. Associations between the QoL-AD and other outcome measures were analyzed using Spearman's rank correlations. Results: A total of 149 patients were included. Mean age (SD) was 72.3 (7.0) years and mean disease duration was 1.4 (1.8) years. Mean MMSE score was 24.6 (2.1). The mean QoL-AD score was 37.9 (4.5). Eighty-three percent (n = 124) of patients had moderate-to-severe hopelessness, 22.1% (n = 33) had depressive symptoms, and 36.9% (n = 55) felt stigmatized. The quality of life showed a significant positive correlation with self-efficacy and negative correlations with depression, emotional and practical consequences, stigma, and hopelessness. Conclusion: Stigma, depressive symptoms, and hopelessness are frequent scenarios in AD negatively impacting quality of life, even in a population with short disease duration and minimal cognitive impairment.Universitat Autònoma de Barcelona 22022-01-0120222022-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/290594https://dx.doi.org/urn:doi:10.3233/JAD-220696reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2905942026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Quality of Life and the Experience of Living with Early-Stage Alzheimer's Disease |
| title |
Quality of Life and the Experience of Living with Early-Stage Alzheimer's Disease |
| spellingShingle |
Quality of Life and the Experience of Living with Early-Stage Alzheimer's Disease Villarejo-Galende, Alberto|||0000-0002-6834-7620 Alzheimer's disease Amyloid Biomarkers Cerebrospinal fluid Magnetic resonance imaging Tau proteins White matter hyperintensities White matter lesions |
| title_short |
Quality of Life and the Experience of Living with Early-Stage Alzheimer's Disease |
| title_full |
Quality of Life and the Experience of Living with Early-Stage Alzheimer's Disease |
| title_fullStr |
Quality of Life and the Experience of Living with Early-Stage Alzheimer's Disease |
| title_full_unstemmed |
Quality of Life and the Experience of Living with Early-Stage Alzheimer's Disease |
| title_sort |
Quality of Life and the Experience of Living with Early-Stage Alzheimer's Disease |
| dc.creator.none.fl_str_mv |
Villarejo-Galende, Alberto|||0000-0002-6834-7620 García-Arcelay, Elena Piñol-Ripoll, Gerard Del Olmo-Rodríguez, Antonio Viñuela, Félix Boada, Mercè|||0000-0003-2617-3009 Franco-Macías, Emilio|||0000-0003-4186-1037 Ibáñez de la Peña, Almudena Riverol, Mario Puig-Pijoan, Albert|||0000-0002-9848-3711 Abizanda-Soler, Pedro Arroyo, Rafael Baquero-Toledo, Miquel Feria-Vilar, Inmaculada Balasa, Mircea|||0000-0002-1795-4228 Berbel, Ángel Rodríguez-Rodríguez, Eloy|||0000-0001-7742-677X Vieira-Campos, Alba García-Ribas, Guillermo Rodrigo-Herrero, Silvia Terrancle, Ángeles Prefasi, Daniel Lleó, Alberto|||0000-0002-2568-5478 Maurino, Jorge|||0000-0001-9858-3555 |
| author |
Villarejo-Galende, Alberto|||0000-0002-6834-7620 |
| author_facet |
Villarejo-Galende, Alberto|||0000-0002-6834-7620 García-Arcelay, Elena Piñol-Ripoll, Gerard Del Olmo-Rodríguez, Antonio Viñuela, Félix Boada, Mercè|||0000-0003-2617-3009 Franco-Macías, Emilio|||0000-0003-4186-1037 Ibáñez de la Peña, Almudena Riverol, Mario Puig-Pijoan, Albert|||0000-0002-9848-3711 Abizanda-Soler, Pedro Arroyo, Rafael Baquero-Toledo, Miquel Feria-Vilar, Inmaculada Balasa, Mircea|||0000-0002-1795-4228 Berbel, Ángel Rodríguez-Rodríguez, Eloy|||0000-0001-7742-677X Vieira-Campos, Alba García-Ribas, Guillermo Rodrigo-Herrero, Silvia Terrancle, Ángeles Prefasi, Daniel Lleó, Alberto|||0000-0002-2568-5478 Maurino, Jorge|||0000-0001-9858-3555 |
| author_role |
author |
| author2 |
García-Arcelay, Elena Piñol-Ripoll, Gerard Del Olmo-Rodríguez, Antonio Viñuela, Félix Boada, Mercè|||0000-0003-2617-3009 Franco-Macías, Emilio|||0000-0003-4186-1037 Ibáñez de la Peña, Almudena Riverol, Mario Puig-Pijoan, Albert|||0000-0002-9848-3711 Abizanda-Soler, Pedro Arroyo, Rafael Baquero-Toledo, Miquel Feria-Vilar, Inmaculada Balasa, Mircea|||0000-0002-1795-4228 Berbel, Ángel Rodríguez-Rodríguez, Eloy|||0000-0001-7742-677X Vieira-Campos, Alba García-Ribas, Guillermo Rodrigo-Herrero, Silvia Terrancle, Ángeles Prefasi, Daniel Lleó, Alberto|||0000-0002-2568-5478 Maurino, Jorge|||0000-0001-9858-3555 |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universitat Autònoma de Barcelona |
| dc.subject.none.fl_str_mv |
Alzheimer's disease Amyloid Biomarkers Cerebrospinal fluid Magnetic resonance imaging Tau proteins White matter hyperintensities White matter lesions |
| topic |
Alzheimer's disease Amyloid Biomarkers Cerebrospinal fluid Magnetic resonance imaging Tau proteins White matter hyperintensities White matter lesions |
| description |
Background: There is a need to better understand the experience of patients living with Alzheimer's disease (AD) in the early stages. Objective: The aim of the study was to evaluate the perception of quality of life in patients with early-stage AD. Methods: A multicenter, non-interventional study was conducted including patients of 50-90 years of age with prodromal or mild AD, a Mini-Mental State Examination (MMSE) score ≥22, and a Clinical Dementia Rating-Global score (CDR-GS) of 0.5.-1.0. The Quality of Life in Alzheimer 's Disease (QoL-AD) questionnaire was used to assess health-related quality of life. A battery of self-report instruments was used to evaluate different psychological and behavioral domains. Associations between the QoL-AD and other outcome measures were analyzed using Spearman's rank correlations. Results: A total of 149 patients were included. Mean age (SD) was 72.3 (7.0) years and mean disease duration was 1.4 (1.8) years. Mean MMSE score was 24.6 (2.1). The mean QoL-AD score was 37.9 (4.5). Eighty-three percent (n = 124) of patients had moderate-to-severe hopelessness, 22.1% (n = 33) had depressive symptoms, and 36.9% (n = 55) felt stigmatized. The quality of life showed a significant positive correlation with self-efficacy and negative correlations with depression, emotional and practical consequences, stigma, and hopelessness. Conclusion: Stigma, depressive symptoms, and hopelessness are frequent scenarios in AD negatively impacting quality of life, even in a population with short disease duration and minimal cognitive impairment. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2 2022-01-01 2022 2022-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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info:eu-repo/semantics/article |
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article |
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https://ddd.uab.cat/record/290594 https://dx.doi.org/urn:doi:10.3233/JAD-220696 |
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https://ddd.uab.cat/record/290594 https://dx.doi.org/urn:doi:10.3233/JAD-220696 |
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Inglés eng |
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Inglés |
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eng |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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