Quality of Life and the Experience of Living with Early-Stage Alzheimer's Disease

Background: There is a need to better understand the experience of patients living with Alzheimer's disease (AD) in the early stages. Objective: The aim of the study was to evaluate the perception of quality of life in patients with early-stage AD. Methods: A multicenter, non-interventional stu...

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Detalles Bibliográficos
Autores: Villarejo-Galende, Alberto|||0000-0002-6834-7620, García-Arcelay, Elena, Piñol-Ripoll, Gerard, Del Olmo-Rodríguez, Antonio, Viñuela, Félix, Boada, Mercè|||0000-0003-2617-3009, Franco-Macías, Emilio|||0000-0003-4186-1037, Ibáñez de la Peña, Almudena, Riverol, Mario, Puig-Pijoan, Albert|||0000-0002-9848-3711, Abizanda-Soler, Pedro, Arroyo, Rafael, Baquero-Toledo, Miquel, Feria-Vilar, Inmaculada, Balasa, Mircea|||0000-0002-1795-4228, Berbel, Ángel, Rodríguez-Rodríguez, Eloy|||0000-0001-7742-677X, Vieira-Campos, Alba, García-Ribas, Guillermo, Rodrigo-Herrero, Silvia, Terrancle, Ángeles, Prefasi, Daniel, Lleó, Alberto|||0000-0002-2568-5478, Maurino, Jorge|||0000-0001-9858-3555
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:290594
Acceso en línea:https://ddd.uab.cat/record/290594
https://dx.doi.org/urn:doi:10.3233/JAD-220696
Access Level:acceso abierto
Palabra clave:Alzheimer's disease
Amyloid
Biomarkers
Cerebrospinal fluid
Magnetic resonance imaging
Tau proteins
White matter hyperintensities
White matter lesions
Descripción
Sumario:Background: There is a need to better understand the experience of patients living with Alzheimer's disease (AD) in the early stages. Objective: The aim of the study was to evaluate the perception of quality of life in patients with early-stage AD. Methods: A multicenter, non-interventional study was conducted including patients of 50-90 years of age with prodromal or mild AD, a Mini-Mental State Examination (MMSE) score ≥22, and a Clinical Dementia Rating-Global score (CDR-GS) of 0.5.-1.0. The Quality of Life in Alzheimer 's Disease (QoL-AD) questionnaire was used to assess health-related quality of life. A battery of self-report instruments was used to evaluate different psychological and behavioral domains. Associations between the QoL-AD and other outcome measures were analyzed using Spearman's rank correlations. Results: A total of 149 patients were included. Mean age (SD) was 72.3 (7.0) years and mean disease duration was 1.4 (1.8) years. Mean MMSE score was 24.6 (2.1). The mean QoL-AD score was 37.9 (4.5). Eighty-three percent (n = 124) of patients had moderate-to-severe hopelessness, 22.1% (n = 33) had depressive symptoms, and 36.9% (n = 55) felt stigmatized. The quality of life showed a significant positive correlation with self-efficacy and negative correlations with depression, emotional and practical consequences, stigma, and hopelessness. Conclusion: Stigma, depressive symptoms, and hopelessness are frequent scenarios in AD negatively impacting quality of life, even in a population with short disease duration and minimal cognitive impairment.

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