Chemical organization of the macaque monkey olfactory bulb: III. Distribution of cholinergic markers

[EN]The distribution patterns of choline acetyltransferase (ChAT) and acetylcholinesterase(AChE) were studied in the olfactory bulb (OB) of three species of macaque. AChE wasdetected by a histochemical method and ChAT immunoreactivity by immunocytochemistry.Similar results were observed in all speci...

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Authors: Porteros Herrero, Ángel Fernando, Gómez Rodríguez, Carmela, Valero, Jorge, Calvo Baltanás, Fernando, Alonso Peña, José Ramón
Format: article
Status:Published version
Publication Date:2007
Country:España
Institution:Universidad de Salamanca (USAL)
Repository:GREDOS. Repositorio Institucional de la Universidad de Salamanca
OAI Identifier:oai:gredos.usal.es:10366/169644
Online Access:http://hdl.handle.net/10366/169644
Access Level:Embargoed access
Keyword:Acetylcholinesterase
Choline acetyltransferase
Olfaction
Primate
Cholinergic Agents
Olfactory Bulb
colinérgicos
bulbo olfatorio
id ES_a95cbf8f8f7dbfc3d5177ccd08e953af
oai_identifier_str oai:gredos.usal.es:10366/169644
network_acronym_str ES
network_name_str España
repository_id_str
spelling Chemical organization of the macaque monkey olfactory bulb: III. Distribution of cholinergic markersPorteros Herrero, Ángel FernandoGómez Rodríguez, CarmelaValero, JorgeCalvo Baltanás, FernandoAlonso Peña, José RamónAcetylcholinesteraseCholine acetyltransferaseOlfactionPrimateCholinergic AgentsOlfactory Bulbcolinérgicosbulbo olfatorio[EN]The distribution patterns of choline acetyltransferase (ChAT) and acetylcholinesterase(AChE) were studied in the olfactory bulb (OB) of three species of macaque. AChE wasdetected by a histochemical method and ChAT immunoreactivity by immunocytochemistry.Similar results were observed in all species analyzed. With the exception of the olfactorynerve layer, all layers of the macaque monkey OB demonstrated a dense innervation ofAChE- and ChAT-positive fibers. The distribution patterns of AChE- and ChAT-labeled fiberswere similar for both cholinergic markers, although the number of AChE-labeled fibers wasclearly higher than the number of ChAT-immunoreactive fibers. The highest density of AChEand ChAT-stained fibers was observed in the interface between the glomerular layer and theexternal plexiform layer and in the internal plexiform layer. Dense bundles of labeled fiberswere observed in the caudal OB, coursing from the olfactory peduncle. All ChAT-immunopositive elements were identified as centrifugal fibers, derived from neurons caudalto the OB. Neither olfactory fibers nor intrinsic neurons were observed after ChAT immu-nocytochemistry. However, a few AChE-positive cells were observed in the glomerular layerand in both external and internal plexiform layers. These neurons were presumably identi-fied as periglomerular cells, superficial short-axon cells, and/or external tufted cells and deepshort-axon cells. Contrary to other neurotransmitters and neuroactive substances, the dis-tribution patterns of ChAT and AChE activities in the macaque monkey OB closely resem-bled the patterns described in macrosmatic mammals and showed laminar differences withthe distribution pattern observed in humans.Wiley202620262007info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10366/169644reponame:GREDOS. Repositorio Institucional de la Universidad de Salamancainstname:Universidad de Salamanca (USAL)InglésJunta de Castilla y LeónAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/embargoedAccessoai:gredos.usal.es:10366/1696442026-06-07T06:28:51Z
dc.title.none.fl_str_mv Chemical organization of the macaque monkey olfactory bulb: III. Distribution of cholinergic markers
title Chemical organization of the macaque monkey olfactory bulb: III. Distribution of cholinergic markers
spellingShingle Chemical organization of the macaque monkey olfactory bulb: III. Distribution of cholinergic markers
Porteros Herrero, Ángel Fernando
Acetylcholinesterase
Choline acetyltransferase
Olfaction
Primate
Cholinergic Agents
Olfactory Bulb
colinérgicos
bulbo olfatorio
title_short Chemical organization of the macaque monkey olfactory bulb: III. Distribution of cholinergic markers
title_full Chemical organization of the macaque monkey olfactory bulb: III. Distribution of cholinergic markers
title_fullStr Chemical organization of the macaque monkey olfactory bulb: III. Distribution of cholinergic markers
title_full_unstemmed Chemical organization of the macaque monkey olfactory bulb: III. Distribution of cholinergic markers
title_sort Chemical organization of the macaque monkey olfactory bulb: III. Distribution of cholinergic markers
dc.creator.none.fl_str_mv Porteros Herrero, Ángel Fernando
Gómez Rodríguez, Carmela
Valero, Jorge
Calvo Baltanás, Fernando
Alonso Peña, José Ramón
author Porteros Herrero, Ángel Fernando
author_facet Porteros Herrero, Ángel Fernando
Gómez Rodríguez, Carmela
Valero, Jorge
Calvo Baltanás, Fernando
Alonso Peña, José Ramón
author_role author
author2 Gómez Rodríguez, Carmela
Valero, Jorge
Calvo Baltanás, Fernando
Alonso Peña, José Ramón
author2_role author
author
author
author
dc.subject.none.fl_str_mv Acetylcholinesterase
Choline acetyltransferase
Olfaction
Primate
Cholinergic Agents
Olfactory Bulb
colinérgicos
bulbo olfatorio
topic Acetylcholinesterase
Choline acetyltransferase
Olfaction
Primate
Cholinergic Agents
Olfactory Bulb
colinérgicos
bulbo olfatorio
description [EN]The distribution patterns of choline acetyltransferase (ChAT) and acetylcholinesterase(AChE) were studied in the olfactory bulb (OB) of three species of macaque. AChE wasdetected by a histochemical method and ChAT immunoreactivity by immunocytochemistry.Similar results were observed in all species analyzed. With the exception of the olfactorynerve layer, all layers of the macaque monkey OB demonstrated a dense innervation ofAChE- and ChAT-positive fibers. The distribution patterns of AChE- and ChAT-labeled fiberswere similar for both cholinergic markers, although the number of AChE-labeled fibers wasclearly higher than the number of ChAT-immunoreactive fibers. The highest density of AChEand ChAT-stained fibers was observed in the interface between the glomerular layer and theexternal plexiform layer and in the internal plexiform layer. Dense bundles of labeled fiberswere observed in the caudal OB, coursing from the olfactory peduncle. All ChAT-immunopositive elements were identified as centrifugal fibers, derived from neurons caudalto the OB. Neither olfactory fibers nor intrinsic neurons were observed after ChAT immu-nocytochemistry. However, a few AChE-positive cells were observed in the glomerular layerand in both external and internal plexiform layers. These neurons were presumably identi-fied as periglomerular cells, superficial short-axon cells, and/or external tufted cells and deepshort-axon cells. Contrary to other neurotransmitters and neuroactive substances, the dis-tribution patterns of ChAT and AChE activities in the macaque monkey OB closely resem-bled the patterns described in macrosmatic mammals and showed laminar differences withthe distribution pattern observed in humans.
publishDate 2007
dc.date.none.fl_str_mv 2007
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10366/169644
url http://hdl.handle.net/10366/169644
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Junta de Castilla y León
dc.rights.none.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/embargoedAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv embargoedAccess
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:GREDOS. Repositorio Institucional de la Universidad de Salamanca
instname:Universidad de Salamanca (USAL)
instname_str Universidad de Salamanca (USAL)
reponame_str GREDOS. Repositorio Institucional de la Universidad de Salamanca
collection GREDOS. Repositorio Institucional de la Universidad de Salamanca
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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