One-week administration of hydroxytyrosol to humans does not activate Phase II enzymes

The notion that (poly)phenols act as direct free radical scavengers is being challenged by mere chemical and biochemical considerations such as bioavailability and intracellular concentrations. An alternative hypothesis that is gaining considerable traction is that (poly)phenols are processed by the...

Descripción completa

Detalles Bibliográficos
Autores: Crespo, María del Carmen, Tomé-Carneiro, Joao, Burgos Ramos, Emma, Loria Kohen, Viviana, Espinosa, Maria Isabel, Herranz, Jesús, Visioli, Francesco
Tipo de recurso: artículo
Fecha de publicación:2015
País:España
Institución:Universidad de Castilla-La Mancha
Repositorio:RUIdeRA. Repositorio Institucional de la UCLM
OAI Identifier:oai:ruidera.uclm.es:10578/9831
Acceso en línea:http://hdl.handle.net/10578/9831
Access Level:acceso abierto
Palabra clave:Hydroxytyrosol
Inflammation
Phase II enzymes
Nrf2
Cardiovascular disease
Mediterranean dieta
id ES_a91c19ed00bae49d1754b45c98cddf87
oai_identifier_str oai:ruidera.uclm.es:10578/9831
network_acronym_str ES
network_name_str España
repository_id_str
spelling One-week administration of hydroxytyrosol to humans does not activate Phase II enzymesCrespo, María del CarmenTomé-Carneiro, JoaoBurgos Ramos, EmmaLoria Kohen, VivianaEspinosa, Maria IsabelHerranz, JesúsVisioli, FrancescoHydroxytyrosolInflammationPhase II enzymesNrf2Cardiovascular diseaseMediterranean dietaThe notion that (poly)phenols act as direct free radical scavengers is being challenged by mere chemical and biochemical considerations such as bioavailability and intracellular concentrations. An alternative hypothesis that is gaining considerable traction is that (poly)phenols are processed by the body as xenobiotics via the Keap1/Nrf2/ARE signaling axis, leading to the induction of Phase II enzymes. However, there are no solid human data to confirm this interesting supposition. In this study, we tested the activities of hydroxytyrosol (HT) on Phase II enzymes expression in a double-blind, randomized, placebo-controlled study. We tested two HT doses, i.e. 5 and 25mg/d, vs. placebo following a Latin square design. We report that HT is well tolerated but does not significantly modify Phase II enzyme expression in peripheral blood mononuclear cells. Moreover, we were unable to record significant effects on a variety of surrogate markers of cardiovascular disease such as lipid profile and inflammation and oxidation markers. Available evidence indicates that the hormesis hypothesis that (poly)phenols activate Phase II enzymes requires solid human confirmation that might be provided by future trials. This study is registered at ClinicalTrials.gov (identifier: NCT02273622).201620162015info:eu-repo/semantics/articletext/plainapplication/pdfhttp://hdl.handle.net/10578/9831reponame:RUIdeRA. Repositorio Institucional de la UCLMinstname:Universidad de Castilla-La ManchaInglésinfo:eu-repo/semantics/openAccessoai:ruidera.uclm.es:10578/98312026-05-27T07:36:41Z
dc.title.none.fl_str_mv One-week administration of hydroxytyrosol to humans does not activate Phase II enzymes
title One-week administration of hydroxytyrosol to humans does not activate Phase II enzymes
spellingShingle One-week administration of hydroxytyrosol to humans does not activate Phase II enzymes
Crespo, María del Carmen
Hydroxytyrosol
Inflammation
Phase II enzymes
Nrf2
Cardiovascular disease
Mediterranean dieta
title_short One-week administration of hydroxytyrosol to humans does not activate Phase II enzymes
title_full One-week administration of hydroxytyrosol to humans does not activate Phase II enzymes
title_fullStr One-week administration of hydroxytyrosol to humans does not activate Phase II enzymes
title_full_unstemmed One-week administration of hydroxytyrosol to humans does not activate Phase II enzymes
title_sort One-week administration of hydroxytyrosol to humans does not activate Phase II enzymes
dc.creator.none.fl_str_mv Crespo, María del Carmen
Tomé-Carneiro, Joao
Burgos Ramos, Emma
Loria Kohen, Viviana
Espinosa, Maria Isabel
Herranz, Jesús
Visioli, Francesco
author Crespo, María del Carmen
author_facet Crespo, María del Carmen
Tomé-Carneiro, Joao
Burgos Ramos, Emma
Loria Kohen, Viviana
Espinosa, Maria Isabel
Herranz, Jesús
Visioli, Francesco
author_role author
author2 Tomé-Carneiro, Joao
Burgos Ramos, Emma
Loria Kohen, Viviana
Espinosa, Maria Isabel
Herranz, Jesús
Visioli, Francesco
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Hydroxytyrosol
Inflammation
Phase II enzymes
Nrf2
Cardiovascular disease
Mediterranean dieta
topic Hydroxytyrosol
Inflammation
Phase II enzymes
Nrf2
Cardiovascular disease
Mediterranean dieta
description The notion that (poly)phenols act as direct free radical scavengers is being challenged by mere chemical and biochemical considerations such as bioavailability and intracellular concentrations. An alternative hypothesis that is gaining considerable traction is that (poly)phenols are processed by the body as xenobiotics via the Keap1/Nrf2/ARE signaling axis, leading to the induction of Phase II enzymes. However, there are no solid human data to confirm this interesting supposition. In this study, we tested the activities of hydroxytyrosol (HT) on Phase II enzymes expression in a double-blind, randomized, placebo-controlled study. We tested two HT doses, i.e. 5 and 25mg/d, vs. placebo following a Latin square design. We report that HT is well tolerated but does not significantly modify Phase II enzyme expression in peripheral blood mononuclear cells. Moreover, we were unable to record significant effects on a variety of surrogate markers of cardiovascular disease such as lipid profile and inflammation and oxidation markers. Available evidence indicates that the hormesis hypothesis that (poly)phenols activate Phase II enzymes requires solid human confirmation that might be provided by future trials. This study is registered at ClinicalTrials.gov (identifier: NCT02273622).
publishDate 2015
dc.date.none.fl_str_mv 2015
2016
2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10578/9831
url http://hdl.handle.net/10578/9831
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/plain
application/pdf
dc.source.none.fl_str_mv reponame:RUIdeRA. Repositorio Institucional de la UCLM
instname:Universidad de Castilla-La Mancha
instname_str Universidad de Castilla-La Mancha
reponame_str RUIdeRA. Repositorio Institucional de la UCLM
collection RUIdeRA. Repositorio Institucional de la UCLM
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869415974669647872
score 15,300724

Similares en LA Referencia