Melatonin and hydroxytyrosol protect against oxidative stress related to the central nervous system after the ingestion of three types of wine by healthy volunteers

Adrenic acid (AdA) and docosahexaenoic acid (DHA) peroxidation produces F2-dihomo-IsoPs and neuroprostanes, which have been related to oxidative damage in the central nervous system. Besides polyphenols, melatonin (MEL) and hydroxytyrosol (OHTyr) could be partly responsible for the antioxidant benef...

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Autores: Marhuenda Hernández, Javier, Medina Escudero, Sonia, Martínez-Hernández, Pedro, Arina, Simón, Zafrilla, Pilar, Mulero, Juana, Oger, Camille, Galano, Jean-Marie, Durand, Thierry, Ferreres, Federico, Gil-Izquierdo, Ángel
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2017
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/374665
Acceso en línea:http://hdl.handle.net/10261/374665
Access Level:acceso abierto
Palabra clave:Neuroprostanes
F2-dihomo-isoprostanes
Melatonin
Hydroxytyrosol
Wine
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spelling Melatonin and hydroxytyrosol protect against oxidative stress related to the central nervous system after the ingestion of three types of wine by healthy volunteersMarhuenda Hernández, JavierMedina Escudero, SoniaMartínez-Hernández, PedroArina, SimónZafrilla, PilarMulero, JuanaOger, CamilleGalano, Jean-MarieDurand, ThierryFerreres, FedericoGil-Izquierdo, ÁngelNeuroprostanesF2-dihomo-isoprostanesMelatoninHydroxytyrosolWineAdrenic acid (AdA) and docosahexaenoic acid (DHA) peroxidation produces F2-dihomo-IsoPs and neuroprostanes, which have been related to oxidative damage in the central nervous system. Besides polyphenols, melatonin (MEL) and hydroxytyrosol (OHTyr) could be partly responsible for the antioxidant benefits of red wine (excluding colon derivatives). In order to elucidate whether these compounds are responsible for the protective antioxidant effects of red wine, a double-blind, crossover, placebo-controlled in vivo study – involving the intake of red wines and their native musts by healthy volunteers – was performed. The urinary metabolites decreased after the administration of red wines, to a greater extent than after the intake of their corresponding musts or ethanol. Melatonin is the most effective compound that protects adrenic acid from oxidative attack, judged by the reduction in the formation of F2-dihomo-isoprostanes. Similarly, hydroxytyrosol, being the most effective bioactive compound in reducing the formation of F3-neuroprostanes n-6 DPA and F4-neuroprostanes, protected docosahexaenoic and eicosapentaenoic acids from oxidative attackThis work has been partially funded by the “Fundación Séneca de la Región de Murcia” Grupo de Excelencia 19900/GERM/15. The authors are grateful to UCAM for the support bridged during the development of the assay for the study. Sonia Medina is grateful to the CICYT for a research contract (AGL2011-23690)Peer reviewedRoyal Society of Chemistry (UK)Fundación SénecaMinisterio de Ciencia e Innovación (España)Medina Escudero, Sonia [0000-0002-7231-6480]Gil-Izquierdo, Ángel [0000-0001-7646-0386]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242017info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/374665reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MICINN//AGL2011-23690https://doi.org/10.1039/C6FO01328GSíinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3746652026-05-22T06:33:51Z
dc.title.none.fl_str_mv Melatonin and hydroxytyrosol protect against oxidative stress related to the central nervous system after the ingestion of three types of wine by healthy volunteers
title Melatonin and hydroxytyrosol protect against oxidative stress related to the central nervous system after the ingestion of three types of wine by healthy volunteers
spellingShingle Melatonin and hydroxytyrosol protect against oxidative stress related to the central nervous system after the ingestion of three types of wine by healthy volunteers
Marhuenda Hernández, Javier
Neuroprostanes
F2-dihomo-isoprostanes
Melatonin
Hydroxytyrosol
Wine
title_short Melatonin and hydroxytyrosol protect against oxidative stress related to the central nervous system after the ingestion of three types of wine by healthy volunteers
title_full Melatonin and hydroxytyrosol protect against oxidative stress related to the central nervous system after the ingestion of three types of wine by healthy volunteers
title_fullStr Melatonin and hydroxytyrosol protect against oxidative stress related to the central nervous system after the ingestion of three types of wine by healthy volunteers
title_full_unstemmed Melatonin and hydroxytyrosol protect against oxidative stress related to the central nervous system after the ingestion of three types of wine by healthy volunteers
title_sort Melatonin and hydroxytyrosol protect against oxidative stress related to the central nervous system after the ingestion of three types of wine by healthy volunteers
dc.creator.none.fl_str_mv Marhuenda Hernández, Javier
Medina Escudero, Sonia
Martínez-Hernández, Pedro
Arina, Simón
Zafrilla, Pilar
Mulero, Juana
Oger, Camille
Galano, Jean-Marie
Durand, Thierry
Ferreres, Federico
Gil-Izquierdo, Ángel
author Marhuenda Hernández, Javier
author_facet Marhuenda Hernández, Javier
Medina Escudero, Sonia
Martínez-Hernández, Pedro
Arina, Simón
Zafrilla, Pilar
Mulero, Juana
Oger, Camille
Galano, Jean-Marie
Durand, Thierry
Ferreres, Federico
Gil-Izquierdo, Ángel
author_role author
author2 Medina Escudero, Sonia
Martínez-Hernández, Pedro
Arina, Simón
Zafrilla, Pilar
Mulero, Juana
Oger, Camille
Galano, Jean-Marie
Durand, Thierry
Ferreres, Federico
Gil-Izquierdo, Ángel
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Fundación Séneca
Ministerio de Ciencia e Innovación (España)
Medina Escudero, Sonia [0000-0002-7231-6480]
Gil-Izquierdo, Ángel [0000-0001-7646-0386]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Neuroprostanes
F2-dihomo-isoprostanes
Melatonin
Hydroxytyrosol
Wine
topic Neuroprostanes
F2-dihomo-isoprostanes
Melatonin
Hydroxytyrosol
Wine
description Adrenic acid (AdA) and docosahexaenoic acid (DHA) peroxidation produces F2-dihomo-IsoPs and neuroprostanes, which have been related to oxidative damage in the central nervous system. Besides polyphenols, melatonin (MEL) and hydroxytyrosol (OHTyr) could be partly responsible for the antioxidant benefits of red wine (excluding colon derivatives). In order to elucidate whether these compounds are responsible for the protective antioxidant effects of red wine, a double-blind, crossover, placebo-controlled in vivo study – involving the intake of red wines and their native musts by healthy volunteers – was performed. The urinary metabolites decreased after the administration of red wines, to a greater extent than after the intake of their corresponding musts or ethanol. Melatonin is the most effective compound that protects adrenic acid from oxidative attack, judged by the reduction in the formation of F2-dihomo-isoprostanes. Similarly, hydroxytyrosol, being the most effective bioactive compound in reducing the formation of F3-neuroprostanes n-6 DPA and F4-neuroprostanes, protected docosahexaenoic and eicosapentaenoic acids from oxidative attack
publishDate 2017
dc.date.none.fl_str_mv 2017
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/374665
url http://hdl.handle.net/10261/374665
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MICINN//AGL2011-23690
https://doi.org/10.1039/C6FO01328G
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Royal Society of Chemistry (UK)
publisher.none.fl_str_mv Royal Society of Chemistry (UK)
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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