Anti-protozoal and anti-bacterial antibiotics that inhibit protein synthesis kill cancer subtypes enriched for stem cell-like properties

Key players in translational regulation such as ribosomes might represent powerful, but hitherto largely unexplored, targets to eliminate drug-refractory cancer stem cells (CSCs). A recent study by the Lisanti group has documented how puromycin, an old antibiotic derived from Streptomyces alboniger...

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Detalles Bibliográficos
Autores: Cuyàs, Elisabet, Martin Castillo, Begoña, Corominas Faja, Bruna, Massaguer i Vall-llovera, Anna, Bosch Barrera, Joaquim, Menéndez Menéndez, Javier Abel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10256/16091
Acceso en línea:http://hdl.handle.net/10256/16091
Access Level:acceso abierto
Palabra clave:Mama -- Càncer
Breast -- Cancer
Cèl·lules mare -- Càncer
Stem cells -- Cancer
Antibiòtics
Antibiotics
Ribosomes
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spelling Anti-protozoal and anti-bacterial antibiotics that inhibit protein synthesis kill cancer subtypes enriched for stem cell-like propertiesCuyàs, ElisabetMartin Castillo, BegoñaCorominas Faja, BrunaMassaguer i Vall-llovera, AnnaBosch Barrera, JoaquimMenéndez Menéndez, Javier AbelMama -- CàncerBreast -- CancerCèl·lules mare -- CàncerStem cells -- CancerAntibiòticsAntibioticsRibosomesKey players in translational regulation such as ribosomes might represent powerful, but hitherto largely unexplored, targets to eliminate drug-refractory cancer stem cells (CSCs). A recent study by the Lisanti group has documented how puromycin, an old antibiotic derived from Streptomyces alboniger that inhibits ribosomal protein translation, can efficiently suppress CSC states in tumorspheres and monolayer cultures. We have used a closely related approach based on Biolog Phenotype Microarrays (PM), which contain tens of lyophilized antimicrobial drugs, to assess the chemosensitivity profiles of breast cancer cell lines enriched for stem cell-like properties. Antibiotics directly targeting active sites of the ribosome including emetine, puromycin and cycloheximide, inhibitors of ribosome biogenesis such as dactinomycin, ribotoxic stress agents such as daunorubicin, and indirect inhibitors of protein synthesis such as acriflavine, had the largest cytotoxic impact against claudin-low and basal-like breast cancer cells. Thus, biologically aggressive, treatment-resistant breast cancer subtypes enriched for stem cell-like properties exhibit exacerbated chemosensitivities to anti-protozoal and anti-bacterial antibiotics targeting protein synthesis. These results suggest that old/existing microbicides might be repurposed not only as new cancer therapeutics, but also might provide the tools and molecular understanding needed to develop second-generation inhibitors of ribosomal translation to eradicate CSC traits in tumor tissuesElsevier2015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionpeer-reviewedapplication/pdfhttp://hdl.handle.net/10256/16091http://hdl.handle.net/10256/16091Cell Cycle, 2015, vol. 14, p. 3527-3532Articles publicats (D-B)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)Inglésinfo:eu-repo/semantics/altIdentifier/doi/10.1080/15384101.2015.1044173info:eu-repo/semantics/altIdentifier/issn/1538-4101info:eu-repo/semantics/altIdentifier/eissn/1551-4005Reconeixement-NoComercial 3.0 Espanyahttp://creativecommons.org/licenses/by-nc/3.0/deed.cainfo:eu-repo/semantics/openAccessoai:recercat.cat:10256/160912026-05-29T05:05:01Z
dc.title.none.fl_str_mv Anti-protozoal and anti-bacterial antibiotics that inhibit protein synthesis kill cancer subtypes enriched for stem cell-like properties
title Anti-protozoal and anti-bacterial antibiotics that inhibit protein synthesis kill cancer subtypes enriched for stem cell-like properties
spellingShingle Anti-protozoal and anti-bacterial antibiotics that inhibit protein synthesis kill cancer subtypes enriched for stem cell-like properties
Cuyàs, Elisabet
Mama -- Càncer
Breast -- Cancer
Cèl·lules mare -- Càncer
Stem cells -- Cancer
Antibiòtics
Antibiotics
Ribosomes
title_short Anti-protozoal and anti-bacterial antibiotics that inhibit protein synthesis kill cancer subtypes enriched for stem cell-like properties
title_full Anti-protozoal and anti-bacterial antibiotics that inhibit protein synthesis kill cancer subtypes enriched for stem cell-like properties
title_fullStr Anti-protozoal and anti-bacterial antibiotics that inhibit protein synthesis kill cancer subtypes enriched for stem cell-like properties
title_full_unstemmed Anti-protozoal and anti-bacterial antibiotics that inhibit protein synthesis kill cancer subtypes enriched for stem cell-like properties
title_sort Anti-protozoal and anti-bacterial antibiotics that inhibit protein synthesis kill cancer subtypes enriched for stem cell-like properties
dc.creator.none.fl_str_mv Cuyàs, Elisabet
Martin Castillo, Begoña
Corominas Faja, Bruna
Massaguer i Vall-llovera, Anna
Bosch Barrera, Joaquim
Menéndez Menéndez, Javier Abel
author Cuyàs, Elisabet
author_facet Cuyàs, Elisabet
Martin Castillo, Begoña
Corominas Faja, Bruna
Massaguer i Vall-llovera, Anna
Bosch Barrera, Joaquim
Menéndez Menéndez, Javier Abel
author_role author
author2 Martin Castillo, Begoña
Corominas Faja, Bruna
Massaguer i Vall-llovera, Anna
Bosch Barrera, Joaquim
Menéndez Menéndez, Javier Abel
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Mama -- Càncer
Breast -- Cancer
Cèl·lules mare -- Càncer
Stem cells -- Cancer
Antibiòtics
Antibiotics
Ribosomes
topic Mama -- Càncer
Breast -- Cancer
Cèl·lules mare -- Càncer
Stem cells -- Cancer
Antibiòtics
Antibiotics
Ribosomes
description Key players in translational regulation such as ribosomes might represent powerful, but hitherto largely unexplored, targets to eliminate drug-refractory cancer stem cells (CSCs). A recent study by the Lisanti group has documented how puromycin, an old antibiotic derived from Streptomyces alboniger that inhibits ribosomal protein translation, can efficiently suppress CSC states in tumorspheres and monolayer cultures. We have used a closely related approach based on Biolog Phenotype Microarrays (PM), which contain tens of lyophilized antimicrobial drugs, to assess the chemosensitivity profiles of breast cancer cell lines enriched for stem cell-like properties. Antibiotics directly targeting active sites of the ribosome including emetine, puromycin and cycloheximide, inhibitors of ribosome biogenesis such as dactinomycin, ribotoxic stress agents such as daunorubicin, and indirect inhibitors of protein synthesis such as acriflavine, had the largest cytotoxic impact against claudin-low and basal-like breast cancer cells. Thus, biologically aggressive, treatment-resistant breast cancer subtypes enriched for stem cell-like properties exhibit exacerbated chemosensitivities to anti-protozoal and anti-bacterial antibiotics targeting protein synthesis. These results suggest that old/existing microbicides might be repurposed not only as new cancer therapeutics, but also might provide the tools and molecular understanding needed to develop second-generation inhibitors of ribosomal translation to eradicate CSC traits in tumor tissues
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
peer-reviewed
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10256/16091
http://hdl.handle.net/10256/16091
url http://hdl.handle.net/10256/16091
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1080/15384101.2015.1044173
info:eu-repo/semantics/altIdentifier/issn/1538-4101
info:eu-repo/semantics/altIdentifier/eissn/1551-4005
dc.rights.none.fl_str_mv Reconeixement-NoComercial 3.0 Espanya
http://creativecommons.org/licenses/by-nc/3.0/deed.ca
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Reconeixement-NoComercial 3.0 Espanya
http://creativecommons.org/licenses/by-nc/3.0/deed.ca
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Cell Cycle, 2015, vol. 14, p. 3527-3532
Articles publicats (D-B)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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