Quercitrin-nanocoated titanium surfaces favour gingival cells against oral bacteria

Many dental implants fail due to the infection and inflammation that walk hand in hand with poor healing and soft tissue integration. Titanium surfaces were nanocoated with quercitrin, a natural flavonoid, with the aim to improve soft tissue integration and increase dental implants success. Streptoc...

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Detalhes bibliográficos
Autores: Gomez-Florit, Manuel, Pacha-Olivenza, Miguel A., Fernandez-Calderon, Maria C., Cordoba, Alba, Gonzalez-Martin, Maria L., Monjo, Marta, Ramis, Joana Maria
Formato: artículo
Fecha de publicación:2016
País:España
Recursos:Conselleria de Salut i Consum del Govern de les Illes Balears
Repositorio:Docusalut
Idioma:inglés
OAI Identifier:oai:docusalut.com:20.500.13003/10447
Acesso em linha:https://hdl.handle.net/20.500.13003/10447
Access Level:acceso abierto
Palavra-chave:Cells, Cultured
Bacterial Adhesion
Anti-Inflammatory Agents
Gingiva
Middle Aged
Male
Dental Implants
Inflammation
Humans
Cell Adhesion
Anti-Bacterial Agents
Adult
Young Adult
Biofilms
Matrix Metalloproteinase 1
Female
Dinoprostone
Streptococcus mutans
Tissue Inhibitor of Metalloproteinase-1
Quercetin
Titanium
Inhibidor Tisular de Metaloproteinasa-1
Inflamación
Células Cultivadas
Adhesión Bacteriana
Adulto Joven
Persona de Mediana Edad
Humanos
Antiinflamatorios
Masculino
Encía
Femenino
Metaloproteinasa 1 de la Matriz
Implantes Dentales
Dinoprostona
Titanio
Biopelículas
Antibacterianos
Adulto
Quercetina
Adhesión Celular
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spelling Quercitrin-nanocoated titanium surfaces favour gingival cells against oral bacteriaGomez-Florit, ManuelPacha-Olivenza, Miguel A.Fernandez-Calderon, Maria C.Cordoba, AlbaGonzalez-Martin, Maria L.Monjo, MartaRamis, Joana MariaCells, CulturedBacterial AdhesionAnti-Inflammatory AgentsGingivaMiddle AgedMaleDental ImplantsInflammationHumansCell AdhesionAnti-Bacterial AgentsAdultYoung AdultBiofilmsMatrix Metalloproteinase 1FemaleDinoprostoneStreptococcus mutansTissue Inhibitor of Metalloproteinase-1QuercetinTitaniumInhibidor Tisular de Metaloproteinasa-1InflamaciónCélulas CultivadasAdhesión BacterianaAdulto JovenPersona de Mediana EdadHumanosAntiinflamatoriosMasculinoEncíaFemeninoMetaloproteinasa 1 de la MatrizImplantes DentalesDinoprostonaTitanioStreptococcus mutansBiopelículasAntibacterianosAdultoQuercetinaAdhesión CelularMany dental implants fail due to the infection and inflammation that walk hand in hand with poor healing and soft tissue integration. Titanium surfaces were nanocoated with quercitrin, a natural flavonoid, with the aim to improve soft tissue integration and increase dental implants success. Streptococcus mutans attachment and biofilm formation was analysed. Then, the anti-inflammatory properties and the potential of quercitrin-nanocoated surfaces to boost soft tissue regeneration were tested using human gingival fibroblasts. An inflammatory situation was mimicked using interleulin-1-beta. We found that quercitrin-nanocoated surfaces decreased initial bacterial adhesion while increasing human gingival fibroblasts attachment. Furthermore, quercitrin-nanocoated Ti increased collagen mRNA levels and decreased matrix metalloproteinase-1/tissue inhibitor of metalloproteinanse-1 mRNA ratio, which is related to a reduced metalloproteinase-mediated collagen degradation, while also decreasing the pro-inflammatory prostaglandin E-2 release under basal and inflammatory conditions. These results suggest that quercitrin-nanocoated surfaces could enhance the soft tissue integration and increase dental implants success.Nature Publishing Group20162016-03-0120162016-03-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.13003/10447reponame:Docusalutinstname:Conselleria de Salut i Consum del Govern de les Illes BalearsInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docusalut.com:20.500.13003/104472026-06-22T12:44:07Z
dc.title.none.fl_str_mv Quercitrin-nanocoated titanium surfaces favour gingival cells against oral bacteria
title Quercitrin-nanocoated titanium surfaces favour gingival cells against oral bacteria
spellingShingle Quercitrin-nanocoated titanium surfaces favour gingival cells against oral bacteria
Gomez-Florit, Manuel
Cells, Cultured
Bacterial Adhesion
Anti-Inflammatory Agents
Gingiva
Middle Aged
Male
Dental Implants
Inflammation
Humans
Cell Adhesion
Anti-Bacterial Agents
Adult
Young Adult
Biofilms
Matrix Metalloproteinase 1
Female
Dinoprostone
Streptococcus mutans
Tissue Inhibitor of Metalloproteinase-1
Quercetin
Titanium
Inhibidor Tisular de Metaloproteinasa-1
Inflamación
Células Cultivadas
Adhesión Bacteriana
Adulto Joven
Persona de Mediana Edad
Humanos
Antiinflamatorios
Masculino
Encía
Femenino
Metaloproteinasa 1 de la Matriz
Implantes Dentales
Dinoprostona
Titanio
Streptococcus mutans
Biopelículas
Antibacterianos
Adulto
Quercetina
Adhesión Celular
title_short Quercitrin-nanocoated titanium surfaces favour gingival cells against oral bacteria
title_full Quercitrin-nanocoated titanium surfaces favour gingival cells against oral bacteria
title_fullStr Quercitrin-nanocoated titanium surfaces favour gingival cells against oral bacteria
title_full_unstemmed Quercitrin-nanocoated titanium surfaces favour gingival cells against oral bacteria
title_sort Quercitrin-nanocoated titanium surfaces favour gingival cells against oral bacteria
dc.creator.none.fl_str_mv Gomez-Florit, Manuel
Pacha-Olivenza, Miguel A.
Fernandez-Calderon, Maria C.
Cordoba, Alba
Gonzalez-Martin, Maria L.
Monjo, Marta
Ramis, Joana Maria
author Gomez-Florit, Manuel
author_facet Gomez-Florit, Manuel
Pacha-Olivenza, Miguel A.
Fernandez-Calderon, Maria C.
Cordoba, Alba
Gonzalez-Martin, Maria L.
Monjo, Marta
Ramis, Joana Maria
author_role author
author2 Pacha-Olivenza, Miguel A.
Fernandez-Calderon, Maria C.
Cordoba, Alba
Gonzalez-Martin, Maria L.
Monjo, Marta
Ramis, Joana Maria
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Cells, Cultured
Bacterial Adhesion
Anti-Inflammatory Agents
Gingiva
Middle Aged
Male
Dental Implants
Inflammation
Humans
Cell Adhesion
Anti-Bacterial Agents
Adult
Young Adult
Biofilms
Matrix Metalloproteinase 1
Female
Dinoprostone
Streptococcus mutans
Tissue Inhibitor of Metalloproteinase-1
Quercetin
Titanium
Inhibidor Tisular de Metaloproteinasa-1
Inflamación
Células Cultivadas
Adhesión Bacteriana
Adulto Joven
Persona de Mediana Edad
Humanos
Antiinflamatorios
Masculino
Encía
Femenino
Metaloproteinasa 1 de la Matriz
Implantes Dentales
Dinoprostona
Titanio
Streptococcus mutans
Biopelículas
Antibacterianos
Adulto
Quercetina
Adhesión Celular
topic Cells, Cultured
Bacterial Adhesion
Anti-Inflammatory Agents
Gingiva
Middle Aged
Male
Dental Implants
Inflammation
Humans
Cell Adhesion
Anti-Bacterial Agents
Adult
Young Adult
Biofilms
Matrix Metalloproteinase 1
Female
Dinoprostone
Streptococcus mutans
Tissue Inhibitor of Metalloproteinase-1
Quercetin
Titanium
Inhibidor Tisular de Metaloproteinasa-1
Inflamación
Células Cultivadas
Adhesión Bacteriana
Adulto Joven
Persona de Mediana Edad
Humanos
Antiinflamatorios
Masculino
Encía
Femenino
Metaloproteinasa 1 de la Matriz
Implantes Dentales
Dinoprostona
Titanio
Streptococcus mutans
Biopelículas
Antibacterianos
Adulto
Quercetina
Adhesión Celular
description Many dental implants fail due to the infection and inflammation that walk hand in hand with poor healing and soft tissue integration. Titanium surfaces were nanocoated with quercitrin, a natural flavonoid, with the aim to improve soft tissue integration and increase dental implants success. Streptococcus mutans attachment and biofilm formation was analysed. Then, the anti-inflammatory properties and the potential of quercitrin-nanocoated surfaces to boost soft tissue regeneration were tested using human gingival fibroblasts. An inflammatory situation was mimicked using interleulin-1-beta. We found that quercitrin-nanocoated surfaces decreased initial bacterial adhesion while increasing human gingival fibroblasts attachment. Furthermore, quercitrin-nanocoated Ti increased collagen mRNA levels and decreased matrix metalloproteinase-1/tissue inhibitor of metalloproteinanse-1 mRNA ratio, which is related to a reduced metalloproteinase-mediated collagen degradation, while also decreasing the pro-inflammatory prostaglandin E-2 release under basal and inflammatory conditions. These results suggest that quercitrin-nanocoated surfaces could enhance the soft tissue integration and increase dental implants success.
publishDate 2016
dc.date.none.fl_str_mv 2016
2016-03-01
2016
2016-03-01
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.13003/10447
url https://hdl.handle.net/20.500.13003/10447
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:Docusalut
instname:Conselleria de Salut i Consum del Govern de les Illes Balears
instname_str Conselleria de Salut i Consum del Govern de les Illes Balears
reponame_str Docusalut
collection Docusalut
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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