Quercitrin-nanocoated titanium surfaces favour gingival cells against oral bacteria
Many dental implants fail due to the infection and inflammation that walk hand in hand with poor healing and soft tissue integration. Titanium surfaces were nanocoated with quercitrin, a natural flavonoid, with the aim to improve soft tissue integration and increase dental implants success. Streptoc...
| Autores: | , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2016 |
| País: | España |
| Institución: | Instituto de Salud Carlos III (ISCIII) |
| Repositorio: | Repisalud |
| Idioma: | inglés |
| OAI Identifier: | oai:repisalud.isciii.es:20.500.12105/20254 |
| Acceso en línea: | http://hdl.handle.net/20.500.12105/20254 |
| Access Level: | acceso abierto |
| Palabra clave: | Dinoprostona Titanio Inhibidor Tisular de Metaloproteinasa-1 Implantes Dentales Metaloproteinasa 1 de la Matriz Femenino Encía Masculino Antiinflamatorios Humanos Persona de Mediana Edad Adulto Joven Adhesión Bacteriana Células Cultivadas Inflamación Adhesión Celular Quercetina Adulto Antibacterianos Biopelículas Streptococcus mutans Matrix Metalloproteinase 1 Biofilms Young Adult Adult Anti-Bacterial Agents Cell Adhesion Humans Inflammation Cells, Cultured Bacterial Adhesion Anti-Inflammatory Agents Gingiva Middle Aged Male Dental Implants Female Dinoprostone Tissue Inhibitor of Metalloproteinase-1 Quercetin Titanium |
| Sumario: | Many dental implants fail due to the infection and inflammation that walk hand in hand with poor healing and soft tissue integration. Titanium surfaces were nanocoated with quercitrin, a natural flavonoid, with the aim to improve soft tissue integration and increase dental implants success. Streptococcus mutans attachment and biofilm formation was analysed. Then, the anti-inflammatory properties and the potential of quercitrin-nanocoated surfaces to boost soft tissue regeneration were tested using human gingival fibroblasts. An inflammatory situation was mimicked using interleulin-1-beta. We found that quercitrin-nanocoated surfaces decreased initial bacterial adhesion while increasing human gingival fibroblasts attachment. Furthermore, quercitrin-nanocoated Ti increased collagen mRNA levels and decreased matrix metalloproteinase-1/tissue inhibitor of metalloproteinanse-1 mRNA ratio, which is related to a reduced metalloproteinase-mediated collagen degradation, while also decreasing the pro-inflammatory prostaglandin E-2 release under basal and inflammatory conditions. These results suggest that quercitrin-nanocoated surfaces could enhance the soft tissue integration and increase dental implants success. |
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