Population pharmacokinetics of ganciclovir after intravenous ganciclovir and oral valganciclovir administration in solid organ transplant patients infected with cytomegalovirus

A population pharmacokinetics analysis was performed after intravenous ganciclovir and oral valganciclovir in solid organ transplant patients with cytomegalovirus. Patients received ganciclovir at 5 mg/kg of body weight (5 days) and then 900 mg of valganciclovir (16 days), both twice daily with dose...

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Detalles Bibliográficos
Autores: Caldés, A. (A.)|||/items/94ed7497-d85a-4a92-af1e-65f4e882ed36, Colom, H. (H.)|||/items/bc43f225-25a0-441e-a0e0-539de3cc89d9, Armendariz, Y. (Y.)|||/items/46f549fb-2955-4234-bb51-06a772da1357, Garrido-Cid, M.J. (María Jesús)|||/items/02b0ddd8-23bb-4f81-8a99-5d1296b3c703, Troconiz, I.F. (Iñaki F.)|||/items/e6782d1e-7a2a-42cc-95d6-55223215bf44, Gil-Vernet, S. (S.)|||/items/1196b9aa-c343-4e85-be62-51fb790e4259, Lloberas, N. (N.)|||/items/2081eb64-206d-4f3e-8cd6-b0bb2a2bbfa0, Pou, L. (L.)|||/items/6e40b772-5dcd-47e7-a78f-489b98bcc9a9, Peraire, C. (Concepción)|||/items/4b20a69b-9272-44dd-954a-cb446dd8784b, Grinyó, J.M. (J. M.)|||/items/bef9745b-064f-4da4-8700-a9e695c87986
Tipo de recurso: artículo
Fecha de publicación:2009
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/21704
Acceso en línea:https://hdl.handle.net/10171/21704
Access Level:acceso abierto
Palabra clave:Pharmacokinetic
Intravenous ganciclovir
Oral valganciclovir
Descripción
Sumario:A population pharmacokinetics analysis was performed after intravenous ganciclovir and oral valganciclovir in solid organ transplant patients with cytomegalovirus. Patients received ganciclovir at 5 mg/kg of body weight (5 days) and then 900 mg of valganciclovir (16 days), both twice daily with dose adjustment for renal function. A total of 382 serum concentrations from days 5 and 15 were analyzed with NONMEM VI. Renal function given by creatinine clearance (CL(CR)) was the most influential covariate in CL. The final pharmacokinetic parameters were as follows: ganciclovir clearance (CL) was 7.49.(CL(CR)/57) liter/h (57 was the mean population value of CL(CR)); the central and peripheral distribution volumes were 31.9 liters and 32.0 liters, respectively; intercompartmental clearance was 10.2 liter/h; the first-order absorption rate constant was 0.895 h(-1); bioavailability was 0.825; and lag time was 0.382 h. The CL(CR) was the best predictor of CL, making dose adjustment by this covariate important to achieve the most efficacious ganciclovir exposure.

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