Clinical Characteristics, Associated Malignancies and Management of Primary Sclerosing Cholangitis in Inflammatory Bowel Disease Patients: A Multicentre Retrospective Cohort Study
Background and Aims: Primary sclerosing cholangitis [PSC] is usually associated with inflammatory bowel disease [IBD]. An increased risk of malignancies, mainly colorectal cancer [CRC] and cholangiocarcinoma [CCA], has been reported in PSC-IBD patients. Our aim was to determine the clinical characte...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2019 |
| País: | España |
| Institución: | Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) |
| Repositorio: | r-FISABIO. Repositorio Institucional de Producción Científica |
| OAI Identifier: | oai:fisabio.fundanetsuite.com:p5457 |
| Acceso en línea: | https://fisabio.portalinvestigacion.com/publicaciones/5457 |
| Access Level: | acceso abierto |
| Palabra clave: | Primary sclerosing cholangitis inflammatory bowel disease malignancy |
| id |
ES_a7bf38df06f3c35c7e8a4253d29faddc |
|---|---|
| oai_identifier_str |
oai:fisabio.fundanetsuite.com:p5457 |
| network_acronym_str |
ES |
| network_name_str |
España |
| repository_id_str |
|
| spelling |
Clinical Characteristics, Associated Malignancies and Management of Primary Sclerosing Cholangitis in Inflammatory Bowel Disease Patients: A Multicentre Retrospective Cohort StudyGuerra, IBujanda, LCastro, JMerino, OTosca, JCamps, BGUTIERREZ, A.Abalos, JGde Castro, LIborra, MCarbajo, AYTaxonera, CRodriguez-Lago, IMesonero, Fde Francisco, RGomez-Gomez, GJChaparro, MTardillo, CARivero, MAlgaba, AArranz, EMCanete, FVicente, RSicilia, BAntolin, BPrieto, VMarquez, LBenitez, JMCamo, PPiqueras, MGargallo, CJHinojosa, EHuguet, JMCalle, JLPVan Domselaar, MRodriguez, CCalvet, XMunoz-Villafranca, CGarcia-Sepulcre, MFMunoz-Garrido, PFernandez-Clotet, AIrwin, LGHernandez, SGuardiola, JSEMPERE, L.Munoza, CGHernandez, VBeltran, BBarrio, JAlba, CMoraleja, ILopez-Sanroman, ARiestra, SMontiel, PMGarre, AArranz, LGarcia, MJArranz, MDMCorsino, PArias, LFernandez-Salazar, LFernandez-Pordomingo, AAndreu, MIglesias, EBer, YMena, RVillarino, MTAMora, MRuiz, LLopez-Serrano, PBlazquez, IVilloria, AFernandez, MBermejo, FBanales, JMDomenech, EGisbert, JPPrimary sclerosing cholangitisinflammatory bowel diseasemalignancyBackground and Aims: Primary sclerosing cholangitis [PSC] is usually associated with inflammatory bowel disease [IBD]. An increased risk of malignancies, mainly colorectal cancer [CRC] and cholangiocarcinoma [CCA], has been reported in PSC-IBD patients. Our aim was to determine the clinical characteristics and management of PSC in IBD patients, and the factors associated with malignancies. Methods: PSC-IBD patients were identified from the Spanish ENEIDA registry of GETECCU. Additional data were collected using the AEG-REDCap electronic data capture tool. Results: In total, 277 PSC-IBD patients were included, with an incidence rate of 61 PSC cases per 100 000 IBD patient-years, 69.7% men, 67.5% ulcerative colitis and mean age at PSC diagnosis of 40 +/- 16 years. Most patients [85.2%] were treated with ursodeoxycholic acid. Liver transplantation was required in 35 patients [12.6%] after 79 months (interquartile range [IQR] 50-139). It was more common in intra- and extrahepatic PSC compared with small-duct PSC (16.3% vs 3.3%; odds ratio [OR] 5.7: 95% confidence interval [CI] = 1.7-19.3). The incidence rate of CRC since PSC diagnosis was 3.3 cases per 1000 patient-years [95% CI = 1.9-5.6]. Having symptoms of PSC at PSC diagnosis was the only factor related to an increased risk of CRC after IBD diagnosis [hazard ratio= 3.3: 95% CI = 1.1-9.9]. CCA was detected in seven patients [2.5%] with intra- and extrahepatic PSC, with median age of 42 years [IQR 39-53], and presented a lower life expectancy compared with patients without CCA and patients with or without CRC. Conclusions: PSC-IBD patients with symptoms of PSC at PSC diagnosis have an increased risk of CRC. CCA was only diagnosed in patients with intra- and extrahepatic PSC and was associated with poor survival.OXFORD UNIV PRESS2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/5457Journal of Crohns & ColitisISSN: 18739946ISSNe: 18764479reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p54572026-06-11T12:45:17Z |
| dc.title.none.fl_str_mv |
Clinical Characteristics, Associated Malignancies and Management of Primary Sclerosing Cholangitis in Inflammatory Bowel Disease Patients: A Multicentre Retrospective Cohort Study |
| title |
Clinical Characteristics, Associated Malignancies and Management of Primary Sclerosing Cholangitis in Inflammatory Bowel Disease Patients: A Multicentre Retrospective Cohort Study |
| spellingShingle |
Clinical Characteristics, Associated Malignancies and Management of Primary Sclerosing Cholangitis in Inflammatory Bowel Disease Patients: A Multicentre Retrospective Cohort Study Guerra, I Primary sclerosing cholangitis inflammatory bowel disease malignancy |
| title_short |
Clinical Characteristics, Associated Malignancies and Management of Primary Sclerosing Cholangitis in Inflammatory Bowel Disease Patients: A Multicentre Retrospective Cohort Study |
| title_full |
Clinical Characteristics, Associated Malignancies and Management of Primary Sclerosing Cholangitis in Inflammatory Bowel Disease Patients: A Multicentre Retrospective Cohort Study |
| title_fullStr |
Clinical Characteristics, Associated Malignancies and Management of Primary Sclerosing Cholangitis in Inflammatory Bowel Disease Patients: A Multicentre Retrospective Cohort Study |
| title_full_unstemmed |
Clinical Characteristics, Associated Malignancies and Management of Primary Sclerosing Cholangitis in Inflammatory Bowel Disease Patients: A Multicentre Retrospective Cohort Study |
| title_sort |
Clinical Characteristics, Associated Malignancies and Management of Primary Sclerosing Cholangitis in Inflammatory Bowel Disease Patients: A Multicentre Retrospective Cohort Study |
| dc.creator.none.fl_str_mv |
Guerra, I Bujanda, L Castro, J Merino, O Tosca, J Camps, B GUTIERREZ, A. Abalos, JG de Castro, L Iborra, M Carbajo, AY Taxonera, C Rodriguez-Lago, I Mesonero, F de Francisco, R Gomez-Gomez, GJ Chaparro, M Tardillo, CA Rivero, M Algaba, A Arranz, EM Canete, F Vicente, R Sicilia, B Antolin, B Prieto, V Marquez, L Benitez, JM Camo, P Piqueras, M Gargallo, CJ Hinojosa, E Huguet, JM Calle, JLP Van Domselaar, M Rodriguez, C Calvet, X Munoz-Villafranca, C Garcia-Sepulcre, MF Munoz-Garrido, P Fernandez-Clotet, A Irwin, LG Hernandez, S Guardiola, J SEMPERE, L. Munoza, CG Hernandez, V Beltran, B Barrio, J Alba, C Moraleja, I Lopez-Sanroman, A Riestra, S Montiel, PM Garre, A Arranz, L Garcia, MJ Arranz, MDM Corsino, P Arias, L Fernandez-Salazar, L Fernandez-Pordomingo, A Andreu, M Iglesias, E Ber, Y Mena, R Villarino, MTA Mora, M Ruiz, L Lopez-Serrano, P Blazquez, I Villoria, A Fernandez, M Bermejo, F Banales, JM Domenech, E Gisbert, JP |
| author |
Guerra, I |
| author_facet |
Guerra, I Bujanda, L Castro, J Merino, O Tosca, J Camps, B GUTIERREZ, A. Abalos, JG de Castro, L Iborra, M Carbajo, AY Taxonera, C Rodriguez-Lago, I Mesonero, F de Francisco, R Gomez-Gomez, GJ Chaparro, M Tardillo, CA Rivero, M Algaba, A Arranz, EM Canete, F Vicente, R Sicilia, B Antolin, B Prieto, V Marquez, L Benitez, JM Camo, P Piqueras, M Gargallo, CJ Hinojosa, E Huguet, JM Calle, JLP Van Domselaar, M Rodriguez, C Calvet, X Munoz-Villafranca, C Garcia-Sepulcre, MF Munoz-Garrido, P Fernandez-Clotet, A Irwin, LG Hernandez, S Guardiola, J SEMPERE, L. Munoza, CG Hernandez, V Beltran, B Barrio, J Alba, C Moraleja, I Lopez-Sanroman, A Riestra, S Montiel, PM Garre, A Arranz, L Garcia, MJ Arranz, MDM Corsino, P Arias, L Fernandez-Salazar, L Fernandez-Pordomingo, A Andreu, M Iglesias, E Ber, Y Mena, R Villarino, MTA Mora, M Ruiz, L Lopez-Serrano, P Blazquez, I Villoria, A Fernandez, M Bermejo, F Banales, JM Domenech, E Gisbert, JP |
| author_role |
author |
| author2 |
Bujanda, L Castro, J Merino, O Tosca, J Camps, B GUTIERREZ, A. Abalos, JG de Castro, L Iborra, M Carbajo, AY Taxonera, C Rodriguez-Lago, I Mesonero, F de Francisco, R Gomez-Gomez, GJ Chaparro, M Tardillo, CA Rivero, M Algaba, A Arranz, EM Canete, F Vicente, R Sicilia, B Antolin, B Prieto, V Marquez, L Benitez, JM Camo, P Piqueras, M Gargallo, CJ Hinojosa, E Huguet, JM Calle, JLP Van Domselaar, M Rodriguez, C Calvet, X Munoz-Villafranca, C Garcia-Sepulcre, MF Munoz-Garrido, P Fernandez-Clotet, A Irwin, LG Hernandez, S Guardiola, J SEMPERE, L. Munoza, CG Hernandez, V Beltran, B Barrio, J Alba, C Moraleja, I Lopez-Sanroman, A Riestra, S Montiel, PM Garre, A Arranz, L Garcia, MJ Arranz, MDM Corsino, P Arias, L Fernandez-Salazar, L Fernandez-Pordomingo, A Andreu, M Iglesias, E Ber, Y Mena, R Villarino, MTA Mora, M Ruiz, L Lopez-Serrano, P Blazquez, I Villoria, A Fernandez, M Bermejo, F Banales, JM Domenech, E Gisbert, JP |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Primary sclerosing cholangitis inflammatory bowel disease malignancy |
| topic |
Primary sclerosing cholangitis inflammatory bowel disease malignancy |
| description |
Background and Aims: Primary sclerosing cholangitis [PSC] is usually associated with inflammatory bowel disease [IBD]. An increased risk of malignancies, mainly colorectal cancer [CRC] and cholangiocarcinoma [CCA], has been reported in PSC-IBD patients. Our aim was to determine the clinical characteristics and management of PSC in IBD patients, and the factors associated with malignancies. Methods: PSC-IBD patients were identified from the Spanish ENEIDA registry of GETECCU. Additional data were collected using the AEG-REDCap electronic data capture tool. Results: In total, 277 PSC-IBD patients were included, with an incidence rate of 61 PSC cases per 100 000 IBD patient-years, 69.7% men, 67.5% ulcerative colitis and mean age at PSC diagnosis of 40 +/- 16 years. Most patients [85.2%] were treated with ursodeoxycholic acid. Liver transplantation was required in 35 patients [12.6%] after 79 months (interquartile range [IQR] 50-139). It was more common in intra- and extrahepatic PSC compared with small-duct PSC (16.3% vs 3.3%; odds ratio [OR] 5.7: 95% confidence interval [CI] = 1.7-19.3). The incidence rate of CRC since PSC diagnosis was 3.3 cases per 1000 patient-years [95% CI = 1.9-5.6]. Having symptoms of PSC at PSC diagnosis was the only factor related to an increased risk of CRC after IBD diagnosis [hazard ratio= 3.3: 95% CI = 1.1-9.9]. CCA was detected in seven patients [2.5%] with intra- and extrahepatic PSC, with median age of 42 years [IQR 39-53], and presented a lower life expectancy compared with patients without CCA and patients with or without CRC. Conclusions: PSC-IBD patients with symptoms of PSC at PSC diagnosis have an increased risk of CRC. CCA was only diagnosed in patients with intra- and extrahepatic PSC and was associated with poor survival. |
| publishDate |
2019 |
| dc.date.none.fl_str_mv |
2019 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://fisabio.portalinvestigacion.com/publicaciones/5457 |
| url |
https://fisabio.portalinvestigacion.com/publicaciones/5457 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
OXFORD UNIV PRESS |
| publisher.none.fl_str_mv |
OXFORD UNIV PRESS |
| dc.source.none.fl_str_mv |
Journal of Crohns & Colitis ISSN: 18739946 ISSNe: 18764479 reponame:r-FISABIO. Repositorio Institucional de Producción Científica instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) |
| instname_str |
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) |
| reponame_str |
r-FISABIO. Repositorio Institucional de Producción Científica |
| collection |
r-FISABIO. Repositorio Institucional de Producción Científica |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
|
| _version_ |
1869415804236201984 |
| score |
15.812429 |