Comparison of Outcomes after Unrelated Double-Unit Cord Blood and Haploidentical Peripheral Blood Stem Cell Transplantation in Adults with Acute Myelogenous Leukemia

Unmanipulated haploidentical hematopoietic stem cell transplantation (HCT) with post-transplantation cyclophosphamide as graft-versus-host disease (GVHD) prophylaxis (haplo-PTCY) and unrelated double-unit umbilical cord blood transplantation (dUCBT) are feasible options for treating patients with hi...

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Authors: Ruggeri, Annalisa|||0000-0002-7261-2765, Galimard, Jacques-Emmanuel|||0000-0001-9102-4427, Labopin, Myriam|||0000-0003-4514-4748, Rafii El Ayoubi, Hanadi|||0000-0003-3344-0611, Blaise, Didier|||0000-0002-5684-9447, Ciceri, Fabio|||0000-0003-0873-0123, Díez-Martín, José Luis|||0000-0003-1869-0129, Cornelissen, Jan, Chevallier, Patrice|||0000-0003-3142-5581, Sánchez Guijo, Fermín|||0000-0002-7076-7739, Nicholson, Emma|||0000-0002-6439-0795, Castagna, Luca, Forcade, Edouard, Kuball, Jürgen, Rovira Argelagués, Montserrat|||0000-0001-7786-9079, Koc, Yener|||0000-0002-3919-9649, Pavlu, Jiri|||0000-0001-5219-5637, Gulbas, Zafar, Vydra, Jan|||0000-0002-4274-3895, Baron, Frederic|||0000-0002-2944-3812, Sanz, Jaime|||0000-0001-6934-4619, Spyridonidis, Alexandros|||0000-0003-3097-2532, Savani, Bipin|||0000-0002-3304-9965, Gluckman, Eliane, Nagler, Arnon, Mohty, Mohamad|||0000-0002-7264-808X
Format: article
Publication Date:2022
Country:España
Institution:Universitat Autònoma de Barcelona
Repository:Dipòsit Digital de Documents de la UAB
Language:English
OAI Identifier:oai:ddd.uab.cat:289894
Online Access:https://ddd.uab.cat/record/289894
https://dx.doi.org/urn:doi:10.1016/j.jtct.2022.07.006
Access Level:Open access
Keyword:Acute myelogenous leukemia
Haploidentical transplant
Double cord blood transplantation
Post-transplantation cyclophosphamide
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spelling Comparison of Outcomes after Unrelated Double-Unit Cord Blood and Haploidentical Peripheral Blood Stem Cell Transplantation in Adults with Acute Myelogenous LeukemiaA Study on Behalf of Eurocord and the Acute Leukemia Working Party of the European Society for Blood and Marrow TransplantationRuggeri, Annalisa|||0000-0002-7261-2765Galimard, Jacques-Emmanuel|||0000-0001-9102-4427Labopin, Myriam|||0000-0003-4514-4748Rafii El Ayoubi, Hanadi|||0000-0003-3344-0611Blaise, Didier|||0000-0002-5684-9447Ciceri, Fabio|||0000-0003-0873-0123Díez-Martín, José Luis|||0000-0003-1869-0129Cornelissen, JanChevallier, Patrice|||0000-0003-3142-5581Sánchez Guijo, Fermín|||0000-0002-7076-7739Nicholson, Emma|||0000-0002-6439-0795Castagna, LucaForcade, EdouardKuball, JürgenRovira Argelagués, Montserrat|||0000-0001-7786-9079Koc, Yener|||0000-0002-3919-9649Pavlu, Jiri|||0000-0001-5219-5637Gulbas, ZafarVydra, Jan|||0000-0002-4274-3895Baron, Frederic|||0000-0002-2944-3812Sanz, Jaime|||0000-0001-6934-4619Spyridonidis, Alexandros|||0000-0003-3097-2532Savani, Bipin|||0000-0002-3304-9965Gluckman, ElianeNagler, ArnonMohty, Mohamad|||0000-0002-7264-808XAcute myelogenous leukemiaHaploidentical transplantDouble cord blood transplantationPost-transplantation cyclophosphamideUnmanipulated haploidentical hematopoietic stem cell transplantation (HCT) with post-transplantation cyclophosphamide as graft-versus-host disease (GVHD) prophylaxis (haplo-PTCY) and unrelated double-unit umbilical cord blood transplantation (dUCBT) are feasible options for treating patients with high-risk acute myelogenous leukemia (AML). This study compared outcomes after dUCBT and haplo-HCT using peripheral blood stem cells (PBSCs) in adult patients with AML in complete remission (CR) who underwent transplantation in European Society for Blood and Marrow Transplantation (EBMT)-affiliated centers. In a population of adults with de novo AML in first or second CR, we compared outcomes after dUCBT (n = 165) and after haplo-PTCY PBSC (n = 544) performed between January 2013 and December 2018. Patients receiving in vivo antithymocyte globulin, Campath, or ex vivo T cell depletion were excluded. The median follow-up was 33 months for the haplo-PTCY arm and 52 months for the dUCBT arm. No statistically significant differences were observed between the 2 arms in the rates of grade II-IV acute graft-versus-host disease (GVHD) (hazard ratio [HR], 1.31; P =. 18), grade III-IV acute GVHD (HR, 1.17; P =. 56), chronic GVHD (HR,. 86; P =. 48), relapse (HR, 1.07; P =. 77), nonrelapse mortality (NRM) (HR,. 94; P =. 77), leukemia-free survival (LFS) (HR,. 99; P =. 95), or overall survival (OS) (HR,. 99; P =. 97). Favorable cytogenetic risk was the sole factor predictive of lower relapse incidence (RI). Younger age at transplantation was associated with lower NRM and higher LFS and OS. Both dUCBT and haplo-PTCY with PBSCs can be considered valid approaches for adult AML patients in CR. New strategies should be investigated in both settings to define the most appropriate conditioning regimen and potentially decrease RI and NRM through better immune reconstitution and optimal supportive care. 22022-01-0120222022-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/289894https://dx.doi.org/urn:doi:10.1016/j.jtct.2022.07.006reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2898942026-06-06T12:50:31Z
dc.title.none.fl_str_mv Comparison of Outcomes after Unrelated Double-Unit Cord Blood and Haploidentical Peripheral Blood Stem Cell Transplantation in Adults with Acute Myelogenous Leukemia
A Study on Behalf of Eurocord and the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation
title Comparison of Outcomes after Unrelated Double-Unit Cord Blood and Haploidentical Peripheral Blood Stem Cell Transplantation in Adults with Acute Myelogenous Leukemia
spellingShingle Comparison of Outcomes after Unrelated Double-Unit Cord Blood and Haploidentical Peripheral Blood Stem Cell Transplantation in Adults with Acute Myelogenous Leukemia
Ruggeri, Annalisa|||0000-0002-7261-2765
Acute myelogenous leukemia
Haploidentical transplant
Double cord blood transplantation
Post-transplantation cyclophosphamide
title_short Comparison of Outcomes after Unrelated Double-Unit Cord Blood and Haploidentical Peripheral Blood Stem Cell Transplantation in Adults with Acute Myelogenous Leukemia
title_full Comparison of Outcomes after Unrelated Double-Unit Cord Blood and Haploidentical Peripheral Blood Stem Cell Transplantation in Adults with Acute Myelogenous Leukemia
title_fullStr Comparison of Outcomes after Unrelated Double-Unit Cord Blood and Haploidentical Peripheral Blood Stem Cell Transplantation in Adults with Acute Myelogenous Leukemia
title_full_unstemmed Comparison of Outcomes after Unrelated Double-Unit Cord Blood and Haploidentical Peripheral Blood Stem Cell Transplantation in Adults with Acute Myelogenous Leukemia
title_sort Comparison of Outcomes after Unrelated Double-Unit Cord Blood and Haploidentical Peripheral Blood Stem Cell Transplantation in Adults with Acute Myelogenous Leukemia
dc.creator.none.fl_str_mv Ruggeri, Annalisa|||0000-0002-7261-2765
Galimard, Jacques-Emmanuel|||0000-0001-9102-4427
Labopin, Myriam|||0000-0003-4514-4748
Rafii El Ayoubi, Hanadi|||0000-0003-3344-0611
Blaise, Didier|||0000-0002-5684-9447
Ciceri, Fabio|||0000-0003-0873-0123
Díez-Martín, José Luis|||0000-0003-1869-0129
Cornelissen, Jan
Chevallier, Patrice|||0000-0003-3142-5581
Sánchez Guijo, Fermín|||0000-0002-7076-7739
Nicholson, Emma|||0000-0002-6439-0795
Castagna, Luca
Forcade, Edouard
Kuball, Jürgen
Rovira Argelagués, Montserrat|||0000-0001-7786-9079
Koc, Yener|||0000-0002-3919-9649
Pavlu, Jiri|||0000-0001-5219-5637
Gulbas, Zafar
Vydra, Jan|||0000-0002-4274-3895
Baron, Frederic|||0000-0002-2944-3812
Sanz, Jaime|||0000-0001-6934-4619
Spyridonidis, Alexandros|||0000-0003-3097-2532
Savani, Bipin|||0000-0002-3304-9965
Gluckman, Eliane
Nagler, Arnon
Mohty, Mohamad|||0000-0002-7264-808X
author Ruggeri, Annalisa|||0000-0002-7261-2765
author_facet Ruggeri, Annalisa|||0000-0002-7261-2765
Galimard, Jacques-Emmanuel|||0000-0001-9102-4427
Labopin, Myriam|||0000-0003-4514-4748
Rafii El Ayoubi, Hanadi|||0000-0003-3344-0611
Blaise, Didier|||0000-0002-5684-9447
Ciceri, Fabio|||0000-0003-0873-0123
Díez-Martín, José Luis|||0000-0003-1869-0129
Cornelissen, Jan
Chevallier, Patrice|||0000-0003-3142-5581
Sánchez Guijo, Fermín|||0000-0002-7076-7739
Nicholson, Emma|||0000-0002-6439-0795
Castagna, Luca
Forcade, Edouard
Kuball, Jürgen
Rovira Argelagués, Montserrat|||0000-0001-7786-9079
Koc, Yener|||0000-0002-3919-9649
Pavlu, Jiri|||0000-0001-5219-5637
Gulbas, Zafar
Vydra, Jan|||0000-0002-4274-3895
Baron, Frederic|||0000-0002-2944-3812
Sanz, Jaime|||0000-0001-6934-4619
Spyridonidis, Alexandros|||0000-0003-3097-2532
Savani, Bipin|||0000-0002-3304-9965
Gluckman, Eliane
Nagler, Arnon
Mohty, Mohamad|||0000-0002-7264-808X
author_role author
author2 Galimard, Jacques-Emmanuel|||0000-0001-9102-4427
Labopin, Myriam|||0000-0003-4514-4748
Rafii El Ayoubi, Hanadi|||0000-0003-3344-0611
Blaise, Didier|||0000-0002-5684-9447
Ciceri, Fabio|||0000-0003-0873-0123
Díez-Martín, José Luis|||0000-0003-1869-0129
Cornelissen, Jan
Chevallier, Patrice|||0000-0003-3142-5581
Sánchez Guijo, Fermín|||0000-0002-7076-7739
Nicholson, Emma|||0000-0002-6439-0795
Castagna, Luca
Forcade, Edouard
Kuball, Jürgen
Rovira Argelagués, Montserrat|||0000-0001-7786-9079
Koc, Yener|||0000-0002-3919-9649
Pavlu, Jiri|||0000-0001-5219-5637
Gulbas, Zafar
Vydra, Jan|||0000-0002-4274-3895
Baron, Frederic|||0000-0002-2944-3812
Sanz, Jaime|||0000-0001-6934-4619
Spyridonidis, Alexandros|||0000-0003-3097-2532
Savani, Bipin|||0000-0002-3304-9965
Gluckman, Eliane
Nagler, Arnon
Mohty, Mohamad|||0000-0002-7264-808X
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Acute myelogenous leukemia
Haploidentical transplant
Double cord blood transplantation
Post-transplantation cyclophosphamide
topic Acute myelogenous leukemia
Haploidentical transplant
Double cord blood transplantation
Post-transplantation cyclophosphamide
description Unmanipulated haploidentical hematopoietic stem cell transplantation (HCT) with post-transplantation cyclophosphamide as graft-versus-host disease (GVHD) prophylaxis (haplo-PTCY) and unrelated double-unit umbilical cord blood transplantation (dUCBT) are feasible options for treating patients with high-risk acute myelogenous leukemia (AML). This study compared outcomes after dUCBT and haplo-HCT using peripheral blood stem cells (PBSCs) in adult patients with AML in complete remission (CR) who underwent transplantation in European Society for Blood and Marrow Transplantation (EBMT)-affiliated centers. In a population of adults with de novo AML in first or second CR, we compared outcomes after dUCBT (n = 165) and after haplo-PTCY PBSC (n = 544) performed between January 2013 and December 2018. Patients receiving in vivo antithymocyte globulin, Campath, or ex vivo T cell depletion were excluded. The median follow-up was 33 months for the haplo-PTCY arm and 52 months for the dUCBT arm. No statistically significant differences were observed between the 2 arms in the rates of grade II-IV acute graft-versus-host disease (GVHD) (hazard ratio [HR], 1.31; P =. 18), grade III-IV acute GVHD (HR, 1.17; P =. 56), chronic GVHD (HR,. 86; P =. 48), relapse (HR, 1.07; P =. 77), nonrelapse mortality (NRM) (HR,. 94; P =. 77), leukemia-free survival (LFS) (HR,. 99; P =. 95), or overall survival (OS) (HR,. 99; P =. 97). Favorable cytogenetic risk was the sole factor predictive of lower relapse incidence (RI). Younger age at transplantation was associated with lower NRM and higher LFS and OS. Both dUCBT and haplo-PTCY with PBSCs can be considered valid approaches for adult AML patients in CR. New strategies should be investigated in both settings to define the most appropriate conditioning regimen and potentially decrease RI and NRM through better immune reconstitution and optimal supportive care.
publishDate 2022
dc.date.none.fl_str_mv 2
2022-01-01
2022
2022-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/289894
https://dx.doi.org/urn:doi:10.1016/j.jtct.2022.07.006
url https://ddd.uab.cat/record/289894
https://dx.doi.org/urn:doi:10.1016/j.jtct.2022.07.006
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
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repository.mail.fl_str_mv
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