Comparison of Outcomes after Unrelated Double-Unit Cord Blood and Haploidentical Peripheral Blood Stem Cell Transplantation in Adults with Acute Myelogenous Leukemia

Unmanipulated haploidentical hematopoietic stem cell transplantation (HCT) with post-transplantation cyclophosphamide as graft-versus-host disease (GVHD) prophylaxis (haplo-PTCY) and unrelated double-unit umbilical cord blood transplantation (dUCBT) are feasible options for treating patients with hi...

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Autores: Ruggeri, Annalisa|||0000-0002-7261-2765, Galimard, Jacques-Emmanuel|||0000-0001-9102-4427, Labopin, Myriam|||0000-0003-4514-4748, Rafii El Ayoubi, Hanadi|||0000-0003-3344-0611, Blaise, Didier|||0000-0002-5684-9447, Ciceri, Fabio|||0000-0003-0873-0123, Díez-Martín, José Luis|||0000-0003-1869-0129, Cornelissen, Jan, Chevallier, Patrice|||0000-0003-3142-5581, Sánchez Guijo, Fermín|||0000-0002-7076-7739, Nicholson, Emma|||0000-0002-6439-0795, Castagna, Luca, Forcade, Edouard, Kuball, Jürgen, Rovira Argelagués, Montserrat|||0000-0001-7786-9079, Koc, Yener|||0000-0002-3919-9649, Pavlu, Jiri|||0000-0001-5219-5637, Gulbas, Zafar, Vydra, Jan|||0000-0002-4274-3895, Baron, Frederic|||0000-0002-2944-3812, Sanz, Jaime|||0000-0001-6934-4619, Spyridonidis, Alexandros|||0000-0003-3097-2532, Savani, Bipin|||0000-0002-3304-9965, Gluckman, Eliane, Nagler, Arnon, Mohty, Mohamad|||0000-0002-7264-808X
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:289894
Acceso en línea:https://ddd.uab.cat/record/289894
https://dx.doi.org/urn:doi:10.1016/j.jtct.2022.07.006
Access Level:acceso abierto
Palabra clave:Acute myelogenous leukemia
Haploidentical transplant
Double cord blood transplantation
Post-transplantation cyclophosphamide
Descripción
Sumario:Unmanipulated haploidentical hematopoietic stem cell transplantation (HCT) with post-transplantation cyclophosphamide as graft-versus-host disease (GVHD) prophylaxis (haplo-PTCY) and unrelated double-unit umbilical cord blood transplantation (dUCBT) are feasible options for treating patients with high-risk acute myelogenous leukemia (AML). This study compared outcomes after dUCBT and haplo-HCT using peripheral blood stem cells (PBSCs) in adult patients with AML in complete remission (CR) who underwent transplantation in European Society for Blood and Marrow Transplantation (EBMT)-affiliated centers. In a population of adults with de novo AML in first or second CR, we compared outcomes after dUCBT (n = 165) and after haplo-PTCY PBSC (n = 544) performed between January 2013 and December 2018. Patients receiving in vivo antithymocyte globulin, Campath, or ex vivo T cell depletion were excluded. The median follow-up was 33 months for the haplo-PTCY arm and 52 months for the dUCBT arm. No statistically significant differences were observed between the 2 arms in the rates of grade II-IV acute graft-versus-host disease (GVHD) (hazard ratio [HR], 1.31; P =. 18), grade III-IV acute GVHD (HR, 1.17; P =. 56), chronic GVHD (HR,. 86; P =. 48), relapse (HR, 1.07; P =. 77), nonrelapse mortality (NRM) (HR,. 94; P =. 77), leukemia-free survival (LFS) (HR,. 99; P =. 95), or overall survival (OS) (HR,. 99; P =. 97). Favorable cytogenetic risk was the sole factor predictive of lower relapse incidence (RI). Younger age at transplantation was associated with lower NRM and higher LFS and OS. Both dUCBT and haplo-PTCY with PBSCs can be considered valid approaches for adult AML patients in CR. New strategies should be investigated in both settings to define the most appropriate conditioning regimen and potentially decrease RI and NRM through better immune reconstitution and optimal supportive care.

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