Nanoengineered delivery of RNA: impact on brain diseases and COVID-19 vaccination
Genetic therapies show great potential for treating various diseases through modulation of the expression of specific genes. Their effective delivery is crucial, particularly for challenging conditions like CNS diseases and SARS-CoV-2 vaccines. Here, we used nanotechnology as a fundamental tool for...
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| Tipo de recurso: | tesis doctoral |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Universidad de Santiago de Compostela (USC) |
| Repositorio: | Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela |
| Idioma: | inglés |
| OAI Identifier: | oai:minerva.usc.gal:10347/32336 |
| Acceso en línea: | http://hdl.handle.net/10347/32336 |
| Access Level: | acceso abierto |
| Palabra clave: | 320802 Acción de los medicamentos 241210 Vacunas |
| Sumario: | Genetic therapies show great potential for treating various diseases through modulation of the expression of specific genes. Their effective delivery is crucial, particularly for challenging conditions like CNS diseases and SARS-CoV-2 vaccines. Here, we used nanotechnology as a fundamental tool for RNA delivery. First, we engineered an ionizable nanoemulsion designed for brain diffusion and delivery of RNA. Second, we explored nanocarriers loaded with siRNA for brain delivery, exploring their performance following alternative administration routes. Finally, we encapsulated mRNAs derived from SARS-CoV-2 within nanoemulsions and polymeric nanocapsules, achieving significant cellular immune responses. |
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