Unexpected genomic variability in clinical and environmental strains of the pathogenic yeast Candida parapsilosis

Invasive candidiasis is the most commonly reported invasive fungal infection worldwide. Although Candida albicans remains the main cause, the incidence of emerging Candida species, such as C. parapsilosis is increasing. It has been postulated that C. parapsilosis clinical isolates result from a rece...

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Detalles Bibliográficos
Autores: Pryszcz, Leszek Piotr, 1985-, Németh, Tibor, Gácser, Attila, Gabaldón Estevan, Juan Antonio, 1973-
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2013
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/22484
Acceso en línea:http://hdl.handle.net/10230/22484
http://dx.doi.org/10.1093/gbe/evt185
Access Level:acceso abierto
Palabra clave:Genòmica
Càndida
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spelling Unexpected genomic variability in clinical and environmental strains of the pathogenic yeast Candida parapsilosisPryszcz, Leszek Piotr, 1985-Németh, TiborGácser, AttilaGabaldón Estevan, Juan Antonio, 1973-GenòmicaCàndidaInvasive candidiasis is the most commonly reported invasive fungal infection worldwide. Although Candida albicans remains the main cause, the incidence of emerging Candida species, such as C. parapsilosis is increasing. It has been postulated that C. parapsilosis clinical isolates result from a recent global expansion of a virulent clone. However, the availability of a single genome for this species has so far prevented testing this hypothesis at genomic scales. We present here the sequence of three additional strains from clinical and environmental samples. Our analyses reveal unexpected patterns of genomic variation, shared among distant strains, that argue against the clonal expansion hypothesis. All strains carry independent expansions involving an arsenite transporter homolog, pointing to the existence of directional selection in the environment, and independent origins of the two clinical isolates. Furthermore, we report the first evidence for the existence of recombination in this species. Altogether, our results shed new light onto the dynamics of genome evolution in C. parapsilosis.This work was supported by the La Caixa-CRG International Fellowship Program to L.P., the TAMOP 4.2.4. A/2-11-1-2012-001 “National Excellence Program” to T.N., and was supported in part by OTKA NF 84006, NN00374 (ERA-Net/nPathoGenomics Program), EMBO Installation Grant and by the Janos Bolyai Fellowship of the Hungarian Academy of Sciences to A.G. T.G. group research is funded in part by a grant from the Spanish Ministry of Economy and Competitiveness (BIO2012-37161), a grant from the Qatar National Research Fund grant (NPRP 5-298-3-086), and a grant from the European Research Council under the European Union’s Seventh Framework Programme (FP/2007-2013)/ERC (grant agreement no. ERC-/n2012-StG-310325)Oxford University Press201420142013info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/22484http://dx.doi.org/10.1093/gbe/evt185reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésGenome Biology and Evolution. 2013;5(12):2382-92info:eu-repo/grantAgreement/EC/FP7/310325info:eu-repo/grantAgreement/ES/3PN/BIO2012-37161© 2013 Leszek P. Pryszcz et al. This is an Open Acces article distributed under a Creative Commons Attribution Licensehttp://creativecommons.org/licenses/by/3.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/224842026-05-29T05:05:01Z
dc.title.none.fl_str_mv Unexpected genomic variability in clinical and environmental strains of the pathogenic yeast Candida parapsilosis
title Unexpected genomic variability in clinical and environmental strains of the pathogenic yeast Candida parapsilosis
spellingShingle Unexpected genomic variability in clinical and environmental strains of the pathogenic yeast Candida parapsilosis
Pryszcz, Leszek Piotr, 1985-
Genòmica
Càndida
title_short Unexpected genomic variability in clinical and environmental strains of the pathogenic yeast Candida parapsilosis
title_full Unexpected genomic variability in clinical and environmental strains of the pathogenic yeast Candida parapsilosis
title_fullStr Unexpected genomic variability in clinical and environmental strains of the pathogenic yeast Candida parapsilosis
title_full_unstemmed Unexpected genomic variability in clinical and environmental strains of the pathogenic yeast Candida parapsilosis
title_sort Unexpected genomic variability in clinical and environmental strains of the pathogenic yeast Candida parapsilosis
dc.creator.none.fl_str_mv Pryszcz, Leszek Piotr, 1985-
Németh, Tibor
Gácser, Attila
Gabaldón Estevan, Juan Antonio, 1973-
author Pryszcz, Leszek Piotr, 1985-
author_facet Pryszcz, Leszek Piotr, 1985-
Németh, Tibor
Gácser, Attila
Gabaldón Estevan, Juan Antonio, 1973-
author_role author
author2 Németh, Tibor
Gácser, Attila
Gabaldón Estevan, Juan Antonio, 1973-
author2_role author
author
author
dc.subject.none.fl_str_mv Genòmica
Càndida
topic Genòmica
Càndida
description Invasive candidiasis is the most commonly reported invasive fungal infection worldwide. Although Candida albicans remains the main cause, the incidence of emerging Candida species, such as C. parapsilosis is increasing. It has been postulated that C. parapsilosis clinical isolates result from a recent global expansion of a virulent clone. However, the availability of a single genome for this species has so far prevented testing this hypothesis at genomic scales. We present here the sequence of three additional strains from clinical and environmental samples. Our analyses reveal unexpected patterns of genomic variation, shared among distant strains, that argue against the clonal expansion hypothesis. All strains carry independent expansions involving an arsenite transporter homolog, pointing to the existence of directional selection in the environment, and independent origins of the two clinical isolates. Furthermore, we report the first evidence for the existence of recombination in this species. Altogether, our results shed new light onto the dynamics of genome evolution in C. parapsilosis.
publishDate 2013
dc.date.none.fl_str_mv 2013
2014
2014
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/22484
http://dx.doi.org/10.1093/gbe/evt185
url http://hdl.handle.net/10230/22484
http://dx.doi.org/10.1093/gbe/evt185
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Genome Biology and Evolution. 2013;5(12):2382-92
info:eu-repo/grantAgreement/EC/FP7/310325
info:eu-repo/grantAgreement/ES/3PN/BIO2012-37161
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/3.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/3.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
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