Abnormal liver function test in patients infected with Coronavirus (SARS-CoV-2): a retrospective Single-Center Study from Spain

The outbreak of the novel coronavirus SARS-CoV-2 epidemic has rapidly spread and still poses a serious threat to healthcare systems worldwide. In the present study, electronic medical records containing clinical indicators related to liver injury in 799 COVID-19-confirmed patients admitted to a hosp...

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Detalles Bibliográficos
Autores: Benede Ubieto, Raquel, Estévez Vázquez, Olga, Flores Perojo, Vicente, Macías Rodríguez, Ricardo U., Ruiz Margáin, Astrid, Martínez Naves, Eduardo, Regueiro González-Barros, José Ramón, Avila, Matías A., Trautwein, Christian, Bañares Cañizares, Rafael, Bosch, J., Cubero Palero, Francisco Javier, Nevzorova, Yulia
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/8508
Acceso en línea:https://hdl.handle.net/20.500.14352/8508
Access Level:acceso abierto
Palabra clave:578.834:616.98
576.3
577.2
616.36
SARS-CoV-2
Liver injury
Pandemic
AST/ALT ratio
Ferritin
Gastroenterología y hepatología
Biología molecular (Biología)
Microbiología (Biología)
3205.03 Gastroenterología
2415 Biología Molecular
2414 Microbiología
Descripción
Sumario:The outbreak of the novel coronavirus SARS-CoV-2 epidemic has rapidly spread and still poses a serious threat to healthcare systems worldwide. In the present study, electronic medical records containing clinical indicators related to liver injury in 799 COVID-19-confirmed patients admitted to a hospital in Madrid (Spain) were extracted and analyzed. Correlation between liver injury and disease outcome was also evaluated. Serum levels of Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Gamma-glutamyltransferase (GGT), Alkaline phosphatase (ALP), Lactate dehydrogenase (LDH) and AST/ALT ratio were elevated above the Upper Limit of Normal (ULN) in 25.73%, 49.17%, 34.62%, 24.21%, 55.84% and 75% of patients, respectively. Interestingly, significant positive correlation between LDH levels and the AST/ALT ratio with disease outcome was found. Our data showed that SARS-CoV-2 virus infection leads to mild, but significant changes in serum markers of liver injury. The upregulated LDH levels as well as AST/ALT ratios upon admission may be used as additional diagnostic characteristic for COVID-19 patients.

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