CD8+ tumour-infiltrating lymphocytes and tumour microenvironment immune types as biomarkers for Immunotherapy in sinonasal intestinal-type adenocarcinoma

TMIT classification did not have additional prognostic value over CD8+ TILs alone. The modest percentage of CD8high/PD-L1pos cases indicates that ITAC is a lowly immunogenic tumour type. Nevertheless, a proportion of ITAC, especially the papillary and colonic subtypes, could benefit from therapy wit...

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Autores: García Marín, Rocío, Reda, Sara, Riobello Suárez, Cristina|||0000-0002-8854-6854, Naves Cabal, Virginia, Suárez Fernández, Laura, Vivanco, Blanca, López Álvarez, Fernando, Llorente Pendás, José Luis|||0000-0001-7713-5526, Hermsen, Mario|||0000-0002-5959-6289
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad de Oviedo (UNIOVI)
Repositorio:RUO. Repositorio Institucional de la Universidad de Oviedo
Idioma:inglés
OAI Identifier:oai:digibuo.uniovi.es:10651/58155
Acceso en línea:http://hdl.handle.net/10651/58155
https://dx.doi.org/10.3390/vaccines8020202
Access Level:acceso abierto
Palabra clave:Cancer nasosinusal
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spelling CD8+ tumour-infiltrating lymphocytes and tumour microenvironment immune types as biomarkers for Immunotherapy in sinonasal intestinal-type adenocarcinomaGarcía Marín, RocíoReda, SaraRiobello Suárez, Cristina|||0000-0002-8854-6854Naves Cabal, VirginiaSuárez Fernández, LauraVivanco, BlancaLópez Álvarez, FernandoLlorente Pendás, José Luis|||0000-0001-7713-5526Hermsen, Mario|||0000-0002-5959-6289Cancer nasosinusalTMIT classification did not have additional prognostic value over CD8+ TILs alone. The modest percentage of CD8high/PD-L1pos cases indicates that ITAC is a lowly immunogenic tumour type. Nevertheless, a proportion of ITAC, especially the papillary and colonic subtypes, could benefit from therapy with immune checkpoint inhibitors.Supported by grants CICPF16008HERM of Fundación AECC, IDI2018/155 Ayudas a Grupos PCTI Principado de Asturias, and CB16/12/00390 from the Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Spain. Plan Nacional de I+D+I 2013-2016 of the Plan Estatal cofinanced by the FEDER Funding Program from the European Union.20202020-04-28journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://hdl.handle.net/10651/58155https://dx.doi.org/10.3390/vaccines8020202reponame:RUO. Repositorio Institucional de la Universidad de Oviedoinstname:Universidad de Oviedo (UNIOVI)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:digibuo.uniovi.es:10651/581552026-06-07T06:38:51Z
dc.title.none.fl_str_mv CD8+ tumour-infiltrating lymphocytes and tumour microenvironment immune types as biomarkers for Immunotherapy in sinonasal intestinal-type adenocarcinoma
title CD8+ tumour-infiltrating lymphocytes and tumour microenvironment immune types as biomarkers for Immunotherapy in sinonasal intestinal-type adenocarcinoma
spellingShingle CD8+ tumour-infiltrating lymphocytes and tumour microenvironment immune types as biomarkers for Immunotherapy in sinonasal intestinal-type adenocarcinoma
García Marín, Rocío
Cancer nasosinusal
title_short CD8+ tumour-infiltrating lymphocytes and tumour microenvironment immune types as biomarkers for Immunotherapy in sinonasal intestinal-type adenocarcinoma
title_full CD8+ tumour-infiltrating lymphocytes and tumour microenvironment immune types as biomarkers for Immunotherapy in sinonasal intestinal-type adenocarcinoma
title_fullStr CD8+ tumour-infiltrating lymphocytes and tumour microenvironment immune types as biomarkers for Immunotherapy in sinonasal intestinal-type adenocarcinoma
title_full_unstemmed CD8+ tumour-infiltrating lymphocytes and tumour microenvironment immune types as biomarkers for Immunotherapy in sinonasal intestinal-type adenocarcinoma
title_sort CD8+ tumour-infiltrating lymphocytes and tumour microenvironment immune types as biomarkers for Immunotherapy in sinonasal intestinal-type adenocarcinoma
dc.creator.none.fl_str_mv García Marín, Rocío
Reda, Sara
Riobello Suárez, Cristina|||0000-0002-8854-6854
Naves Cabal, Virginia
Suárez Fernández, Laura
Vivanco, Blanca
López Álvarez, Fernando
Llorente Pendás, José Luis|||0000-0001-7713-5526
Hermsen, Mario|||0000-0002-5959-6289
author García Marín, Rocío
author_facet García Marín, Rocío
Reda, Sara
Riobello Suárez, Cristina|||0000-0002-8854-6854
Naves Cabal, Virginia
Suárez Fernández, Laura
Vivanco, Blanca
López Álvarez, Fernando
Llorente Pendás, José Luis|||0000-0001-7713-5526
Hermsen, Mario|||0000-0002-5959-6289
author_role author
author2 Reda, Sara
Riobello Suárez, Cristina|||0000-0002-8854-6854
Naves Cabal, Virginia
Suárez Fernández, Laura
Vivanco, Blanca
López Álvarez, Fernando
Llorente Pendás, José Luis|||0000-0001-7713-5526
Hermsen, Mario|||0000-0002-5959-6289
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Cancer nasosinusal
topic Cancer nasosinusal
description TMIT classification did not have additional prognostic value over CD8+ TILs alone. The modest percentage of CD8high/PD-L1pos cases indicates that ITAC is a lowly immunogenic tumour type. Nevertheless, a proportion of ITAC, especially the papillary and colonic subtypes, could benefit from therapy with immune checkpoint inhibitors.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-04-28
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10651/58155
https://dx.doi.org/10.3390/vaccines8020202
url http://hdl.handle.net/10651/58155
https://dx.doi.org/10.3390/vaccines8020202
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:RUO. Repositorio Institucional de la Universidad de Oviedo
instname:Universidad de Oviedo (UNIOVI)
instname_str Universidad de Oviedo (UNIOVI)
reponame_str RUO. Repositorio Institucional de la Universidad de Oviedo
collection RUO. Repositorio Institucional de la Universidad de Oviedo
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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