CD8+ tumour-infiltrating lymphocytes and tumour microenvironment immune types as biomarkers for Immunotherapy in sinonasal intestinal-type adenocarcinoma

TMIT classification did not have additional prognostic value over CD8+ TILs alone. The modest percentage of CD8high/PD-L1pos cases indicates that ITAC is a lowly immunogenic tumour type. Nevertheless, a proportion of ITAC, especially the papillary and colonic subtypes, could benefit from therapy wit...

Descripción completa

Detalles Bibliográficos
Autores: García Marín, Rocío, Reda, Sara, Riobello Suárez, Cristina|||0000-0002-8854-6854, Naves Cabal, Virginia, Suárez Fernández, Laura, Vivanco, Blanca, López Álvarez, Fernando, Llorente Pendás, José Luis|||0000-0001-7713-5526, Hermsen, Mario|||0000-0002-5959-6289
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad de Oviedo (UNIOVI)
Repositorio:RUO. Repositorio Institucional de la Universidad de Oviedo
Idioma:inglés
OAI Identifier:oai:digibuo.uniovi.es:10651/58155
Acceso en línea:http://hdl.handle.net/10651/58155
https://dx.doi.org/10.3390/vaccines8020202
Access Level:acceso abierto
Palabra clave:Cancer nasosinusal
Descripción
Sumario:TMIT classification did not have additional prognostic value over CD8+ TILs alone. The modest percentage of CD8high/PD-L1pos cases indicates that ITAC is a lowly immunogenic tumour type. Nevertheless, a proportion of ITAC, especially the papillary and colonic subtypes, could benefit from therapy with immune checkpoint inhibitors.

Similares en LA Referencia