New selective molecular recognition elements and amplification methods for the development of optical (bio)sensors
Mycotoxins are low molecular weight substances produced as secondary metabolites by a wide variety of filamentous fungi that can be found as natural contaminants in many foods and feeds. The number of toxic fungal metabolites currently known exceeds the thousand units, but only a few of them are con...
| Autor: | |
|---|---|
| Tipo de recurso: | tesis doctoral |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Universidad Complutense de Madrid (UCM) |
| Repositorio: | Docta Complutense |
| Idioma: | inglés |
| OAI Identifier: | oai:docta.ucm.es:20.500.14352/3713 |
| Acceso en línea: | https://hdl.handle.net/20.500.14352/3713 |
| Access Level: | acceso abierto |
| Palabra clave: | 53.082.9(043.2) Biosensors Biosensores Química 23 Química |
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New selective molecular recognition elements and amplification methods for the development of optical (bio)sensorsNuevos elementos de reconocimiento molecular selectivo y métodos de amplificación para el desarrollo de (bio)sensores ópticosLuque Uria, Álvaro53.082.9(043.2)BiosensorsBiosensoresQuímica23 QuímicaMycotoxins are low molecular weight substances produced as secondary metabolites by a wide variety of filamentous fungi that can be found as natural contaminants in many foods and feeds. The number of toxic fungal metabolites currently known exceeds the thousand units, but only a few of them are considered a threat to humans and animal health. Exposure to mycotoxins can be due to the consumption of contaminated foodstuff, but also by inhalation of dust containing mycotoxigenic fungal spores. It has been estimated that nearly 40% of the global crops can be contaminated with mycotoxins. Hence, the development of analytical methods that can detect these mycotoxins in foodstuff are essential. On the other hand, despite their elevated risk infood quality, several mycotoxins present medical applications, for example as immunosuppressant drugs for organ transplantation. However, a limitation for this application is the narrow therapeutic window presented by these drugs, e.g., mycophenolic acid. High doses of these compounds can cause serious adverse health effects in humans, but little doses could not be sufficient to prevent organ rejection in transplanted patients. Thus, it is also of utmost importance to monitor the levels of these compounds in blood to improve the clinical efficacy of the immunosuppressant...Universidad Complutense de MadridMoreno Bondi, María CruzBenito Peña, María ElenaUniversidad Complutense de Madrid20222022-06-2420222022-06-24doctoral thesishttp://purl.org/coar/resource_type/c_db06info:eu-repo/semantics/doctoralThesisapplication/pdfhttps://hdl.handle.net/20.500.14352/3713reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/37132026-06-02T12:44:21Z |
| dc.title.none.fl_str_mv |
New selective molecular recognition elements and amplification methods for the development of optical (bio)sensors Nuevos elementos de reconocimiento molecular selectivo y métodos de amplificación para el desarrollo de (bio)sensores ópticos |
| title |
New selective molecular recognition elements and amplification methods for the development of optical (bio)sensors |
| spellingShingle |
New selective molecular recognition elements and amplification methods for the development of optical (bio)sensors Luque Uria, Álvaro 53.082.9(043.2) Biosensors Biosensores Química 23 Química |
| title_short |
New selective molecular recognition elements and amplification methods for the development of optical (bio)sensors |
| title_full |
New selective molecular recognition elements and amplification methods for the development of optical (bio)sensors |
| title_fullStr |
New selective molecular recognition elements and amplification methods for the development of optical (bio)sensors |
| title_full_unstemmed |
New selective molecular recognition elements and amplification methods for the development of optical (bio)sensors |
| title_sort |
New selective molecular recognition elements and amplification methods for the development of optical (bio)sensors |
| dc.creator.none.fl_str_mv |
Luque Uria, Álvaro |
| author |
Luque Uria, Álvaro |
| author_facet |
Luque Uria, Álvaro |
| author_role |
author |
| dc.contributor.none.fl_str_mv |
Moreno Bondi, María Cruz Benito Peña, María Elena Universidad Complutense de Madrid |
| dc.subject.none.fl_str_mv |
53.082.9(043.2) Biosensors Biosensores Química 23 Química |
| topic |
53.082.9(043.2) Biosensors Biosensores Química 23 Química |
| description |
Mycotoxins are low molecular weight substances produced as secondary metabolites by a wide variety of filamentous fungi that can be found as natural contaminants in many foods and feeds. The number of toxic fungal metabolites currently known exceeds the thousand units, but only a few of them are considered a threat to humans and animal health. Exposure to mycotoxins can be due to the consumption of contaminated foodstuff, but also by inhalation of dust containing mycotoxigenic fungal spores. It has been estimated that nearly 40% of the global crops can be contaminated with mycotoxins. Hence, the development of analytical methods that can detect these mycotoxins in foodstuff are essential. On the other hand, despite their elevated risk infood quality, several mycotoxins present medical applications, for example as immunosuppressant drugs for organ transplantation. However, a limitation for this application is the narrow therapeutic window presented by these drugs, e.g., mycophenolic acid. High doses of these compounds can cause serious adverse health effects in humans, but little doses could not be sufficient to prevent organ rejection in transplanted patients. Thus, it is also of utmost importance to monitor the levels of these compounds in blood to improve the clinical efficacy of the immunosuppressant... |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022 2022-06-24 2022 2022-06-24 |
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doctoral thesis http://purl.org/coar/resource_type/c_db06 |
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info:eu-repo/semantics/doctoralThesis |
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doctoralThesis |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/20.500.14352/3713 |
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https://hdl.handle.net/20.500.14352/3713 |
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Inglés eng |
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Inglés |
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eng |
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open access http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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application/pdf |
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Universidad Complutense de Madrid |
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Universidad Complutense de Madrid |
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reponame:Docta Complutense instname:Universidad Complutense de Madrid (UCM) |
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Universidad Complutense de Madrid (UCM) |
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Docta Complutense |
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15,301603 |