Hydroxychloroquine is associated with a lower risk of polyautoimmunity: data from the RELESSER Registry

Mena-Vazquez, Natalia; Fernandez-Nebro, Antonio; Pego-Reigosa, Jose Maria; Galindo, Maria; Melissa-Anzola, Ana; Uriarte Isacelaya, Esther; Olive-Marques, Alejandro; Aurrecoechea, Elena; Freire, Mercedes; Tomero, Eva; Garcia-Villanueva, Maria Jesus; Stoye, Claudia; Salas-Heredia, Esteban; Bernal-Vidal, Jose Antonio; Salgado, Eva; Blanco, Ricardo; Novoa, Francisco Javier; Ibáñez-Barceló, Mónica; Torrente-Segarra, Vicente; Narvaez, Javier; Calvet, Joan; Moriano Morales, Clara; Vazquez-Rodriguez, Tomas; Garcia de la Pena, Paloma; Bohorquez, Cristina; Andreu-Sanchez, Jose Luis; Cobo-Ibáñez, Tatiana; Bonilla, Gema; Lozano-Rivas, Nuria; Montilla, Carlos; Toyos, Francisco Javier; Marenco De la Fuente, Jose Luis; Exposito, Lorena; Ruiz Lucea, Esther; Vals, Elia; Manero-Ruiz, Javier; Rua-Figueroa, Inigo

Hydroxychloroquine is associated with a lower risk of polyautoimmunity: data from the RELESSER Registry

Objectives. This article estimates the frequency of polyautoimmunity and associated factors in a large retrospective cohort of patients with SLE. Methods. RELESSER (Spanish Society of Rheumatology Lupus Registry) is a nationwide multicentre, hospital-based registry of SLE patients. This is a cross-s...

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Autores:	Mena-Vazquez, Natalia, Fernandez-Nebro, Antonio, Pego-Reigosa, Jose Maria, Galindo, Maria, Melissa-Anzola, Ana, Uriarte Isacelaya, Esther, Olive-Marques, Alejandro, Aurrecoechea, Elena, Freire, Mercedes, Tomero, Eva, Garcia-Villanueva, Maria Jesus, Stoye, Claudia, Salas-Heredia, Esteban, Bernal-Vidal, Jose Antonio, Salgado, Eva, Blanco, Ricardo, Novoa, Francisco Javier, Ibáñez-Barceló, Mónica, Torrente-Segarra, Vicente, Narvaez, Javier, Calvet, Joan, Moriano Morales, Clara, Vazquez-Rodriguez, Tomas, Garcia de la Pena, Paloma, Bohorquez, Cristina, Andreu-Sanchez, Jose Luis, Cobo-Ibáñez, Tatiana, Bonilla, Gema, Lozano-Rivas, Nuria, Montilla, Carlos, Toyos, Francisco Javier, Marenco De la Fuente, Jose Luis, Exposito, Lorena, Ruiz Lucea, Esther, Vals, Elia, Manero-Ruiz, Javier, Rua-Figueroa, Inigo
Tipo de recurso:	artículo
Fecha de publicación:	2020
País:	España
Institución:	Conselleria de Salut i Consum del Govern de les Illes Balears
Repositorio:	Docusalut
Idioma:	inglés
OAI Identifier:	oai:docusalut.com:20.500.13003/17217
Acceso en línea:	https://hdl.handle.net/20.500.13003/17217
Access Level:	acceso abierto
Palabra clave:	Cross-Sectional Studies Antirheumatic Agents Registries Lupus Erythematosus, Systemic Autoimmunity Female Male Middle Aged Hydroxychloroquine Humans Adult Young Adult Autoimmune Diseases Adulto Sistema de Registros Enfermedades Autoinmunes Adulto Joven Antirreumáticos Lupus Eritematoso Sistémico Autoinmunidad Femenino Masculino Hidroxicloroquina Estudios Transversales Humanos Persona de Mediana Edad polyautoimmunity systemic lupus erythematosus multiple autoimmune syndrome

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spelling	Hydroxychloroquine is associated with a lower risk of polyautoimmunity: data from the RELESSER RegistryMena-Vazquez, NataliaFernandez-Nebro, AntonioPego-Reigosa, Jose MariaGalindo, MariaMelissa-Anzola, AnaUriarte Isacelaya, EstherOlive-Marques, AlejandroAurrecoechea, ElenaFreire, MercedesTomero, EvaGarcia-Villanueva, Maria JesusStoye, ClaudiaSalas-Heredia, EstebanBernal-Vidal, Jose AntonioSalgado, EvaBlanco, RicardoNovoa, Francisco JavierIbáñez-Barceló, MónicaTorrente-Segarra, VicenteNarvaez, JavierCalvet, JoanMoriano Morales, ClaraVazquez-Rodriguez, TomasGarcia de la Pena, PalomaBohorquez, CristinaAndreu-Sanchez, Jose LuisCobo-Ibáñez, TatianaBonilla, GemaLozano-Rivas, NuriaMontilla, CarlosToyos, Francisco JavierMarenco De la Fuente, Jose LuisExposito, LorenaRuiz Lucea, EstherVals, EliaManero-Ruiz, JavierRua-Figueroa, InigoCross-Sectional StudiesAntirheumatic AgentsRegistriesLupus Erythematosus, SystemicAutoimmunityFemaleMaleMiddle AgedHydroxychloroquineHumansAdultYoung AdultAutoimmune DiseasesAdultoSistema de RegistrosEnfermedades AutoinmunesAdulto JovenAntirreumáticosLupus Eritematoso SistémicoAutoinmunidadFemeninoMasculinoHidroxicloroquinaEstudios TransversalesHumanosPersona de Mediana Edadpolyautoimmunitysystemic lupus erythematosusmultiple autoimmune syndromeObjectives. This article estimates the frequency of polyautoimmunity and associated factors in a large retrospective cohort of patients with SLE. Methods. RELESSER (Spanish Society of Rheumatology Lupus Registry) is a nationwide multicentre, hospital-based registry of SLE patients. This is a cross-sectional study. The main variable was polyautoimmunity, which was defined as the co-occurrence of SLE and another autoimmune disease, such as autoimmune thyroiditis, RA, scleroderma, inflammatory myopathy and MCTD. We also recorded the presence of multiple autoimmune syndrome, secondary SS, secondary APS and a family history of autoimmune disease. Multiple logistic regression analysis was performed to investigate possible risk factors for polyautoimmunity. Results. Of the 3679 patients who fulfilled the criteria for SLE, 502 (13.6%) had polyautoimmunity. The most frequent types were autoimmune thyroiditis (7.9%), other systemic autoimmune diseases (6.2%), secondary SS (14.1%) and secondary APS (13.7%). Multiple autoimmune syndrome accounted for 10.2% of all cases of polyautoimmunity. A family history was recorded in 11.8%. According to the multivariate analysis, the factors associated with polyautoimmunity were female sex [odds ratio (95% CI), 1.72 (1.07, 2.72)], RP [1.63 (1.29, 2.05)], interstitial lung disease [3.35 (1.84, 6.01)], Jaccoud arthropathy [1.92 (1.40, 2.63)], anti-Ro/SSA and/or anti-La/SSB autoantibodies [2.03 (1.55, 2.67)], anti-RNP antibodies [1.48 (1.16, 1.90)], MTX [1.67 (1.26, 2.18)] and antimalarial drugs [0.50 (0.38, 0.67)]. Conclusion. Patients with SLE frequently present polyautoimmunity. We observed clinical and analytical characteristics associated with polyautoimmunity. Our finding that antimalarial drugs protected against polyautoimmunity should be verified in future studies.Oxford Univ Press20202020-08-0120202020-08-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.13003/17217reponame:Docusalutinstname:Conselleria de Salut i Consum del Govern de les Illes BalearsInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:docusalut.com:20.500.13003/172172026-06-22T12:44:07Z
dc.title.none.fl_str_mv	Hydroxychloroquine is associated with a lower risk of polyautoimmunity: data from the RELESSER Registry
title	Hydroxychloroquine is associated with a lower risk of polyautoimmunity: data from the RELESSER Registry
spellingShingle	Hydroxychloroquine is associated with a lower risk of polyautoimmunity: data from the RELESSER Registry Mena-Vazquez, Natalia Cross-Sectional Studies Antirheumatic Agents Registries Lupus Erythematosus, Systemic Autoimmunity Female Male Middle Aged Hydroxychloroquine Humans Adult Young Adult Autoimmune Diseases Adulto Sistema de Registros Enfermedades Autoinmunes Adulto Joven Antirreumáticos Lupus Eritematoso Sistémico Autoinmunidad Femenino Masculino Hidroxicloroquina Estudios Transversales Humanos Persona de Mediana Edad polyautoimmunity systemic lupus erythematosus multiple autoimmune syndrome
title_short	Hydroxychloroquine is associated with a lower risk of polyautoimmunity: data from the RELESSER Registry
title_full	Hydroxychloroquine is associated with a lower risk of polyautoimmunity: data from the RELESSER Registry
title_fullStr	Hydroxychloroquine is associated with a lower risk of polyautoimmunity: data from the RELESSER Registry
title_full_unstemmed	Hydroxychloroquine is associated with a lower risk of polyautoimmunity: data from the RELESSER Registry
title_sort	Hydroxychloroquine is associated with a lower risk of polyautoimmunity: data from the RELESSER Registry
dc.creator.none.fl_str_mv	Mena-Vazquez, Natalia Fernandez-Nebro, Antonio Pego-Reigosa, Jose Maria Galindo, Maria Melissa-Anzola, Ana Uriarte Isacelaya, Esther Olive-Marques, Alejandro Aurrecoechea, Elena Freire, Mercedes Tomero, Eva Garcia-Villanueva, Maria Jesus Stoye, Claudia Salas-Heredia, Esteban Bernal-Vidal, Jose Antonio Salgado, Eva Blanco, Ricardo Novoa, Francisco Javier Ibáñez-Barceló, Mónica Torrente-Segarra, Vicente Narvaez, Javier Calvet, Joan Moriano Morales, Clara Vazquez-Rodriguez, Tomas Garcia de la Pena, Paloma Bohorquez, Cristina Andreu-Sanchez, Jose Luis Cobo-Ibáñez, Tatiana Bonilla, Gema Lozano-Rivas, Nuria Montilla, Carlos Toyos, Francisco Javier Marenco De la Fuente, Jose Luis Exposito, Lorena Ruiz Lucea, Esther Vals, Elia Manero-Ruiz, Javier Rua-Figueroa, Inigo
author	Mena-Vazquez, Natalia
author_facet	Mena-Vazquez, Natalia Fernandez-Nebro, Antonio Pego-Reigosa, Jose Maria Galindo, Maria Melissa-Anzola, Ana Uriarte Isacelaya, Esther Olive-Marques, Alejandro Aurrecoechea, Elena Freire, Mercedes Tomero, Eva Garcia-Villanueva, Maria Jesus Stoye, Claudia Salas-Heredia, Esteban Bernal-Vidal, Jose Antonio Salgado, Eva Blanco, Ricardo Novoa, Francisco Javier Ibáñez-Barceló, Mónica Torrente-Segarra, Vicente Narvaez, Javier Calvet, Joan Moriano Morales, Clara Vazquez-Rodriguez, Tomas Garcia de la Pena, Paloma Bohorquez, Cristina Andreu-Sanchez, Jose Luis Cobo-Ibáñez, Tatiana Bonilla, Gema Lozano-Rivas, Nuria Montilla, Carlos Toyos, Francisco Javier Marenco De la Fuente, Jose Luis Exposito, Lorena Ruiz Lucea, Esther Vals, Elia Manero-Ruiz, Javier Rua-Figueroa, Inigo
author_role	author
author2	Fernandez-Nebro, Antonio Pego-Reigosa, Jose Maria Galindo, Maria Melissa-Anzola, Ana Uriarte Isacelaya, Esther Olive-Marques, Alejandro Aurrecoechea, Elena Freire, Mercedes Tomero, Eva Garcia-Villanueva, Maria Jesus Stoye, Claudia Salas-Heredia, Esteban Bernal-Vidal, Jose Antonio Salgado, Eva Blanco, Ricardo Novoa, Francisco Javier Ibáñez-Barceló, Mónica Torrente-Segarra, Vicente Narvaez, Javier Calvet, Joan Moriano Morales, Clara Vazquez-Rodriguez, Tomas Garcia de la Pena, Paloma Bohorquez, Cristina Andreu-Sanchez, Jose Luis Cobo-Ibáñez, Tatiana Bonilla, Gema Lozano-Rivas, Nuria Montilla, Carlos Toyos, Francisco Javier Marenco De la Fuente, Jose Luis Exposito, Lorena Ruiz Lucea, Esther Vals, Elia Manero-Ruiz, Javier Rua-Figueroa, Inigo
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv	Cross-Sectional Studies Antirheumatic Agents Registries Lupus Erythematosus, Systemic Autoimmunity Female Male Middle Aged Hydroxychloroquine Humans Adult Young Adult Autoimmune Diseases Adulto Sistema de Registros Enfermedades Autoinmunes Adulto Joven Antirreumáticos Lupus Eritematoso Sistémico Autoinmunidad Femenino Masculino Hidroxicloroquina Estudios Transversales Humanos Persona de Mediana Edad polyautoimmunity systemic lupus erythematosus multiple autoimmune syndrome
topic	Cross-Sectional Studies Antirheumatic Agents Registries Lupus Erythematosus, Systemic Autoimmunity Female Male Middle Aged Hydroxychloroquine Humans Adult Young Adult Autoimmune Diseases Adulto Sistema de Registros Enfermedades Autoinmunes Adulto Joven Antirreumáticos Lupus Eritematoso Sistémico Autoinmunidad Femenino Masculino Hidroxicloroquina Estudios Transversales Humanos Persona de Mediana Edad polyautoimmunity systemic lupus erythematosus multiple autoimmune syndrome
description	Objectives. This article estimates the frequency of polyautoimmunity and associated factors in a large retrospective cohort of patients with SLE. Methods. RELESSER (Spanish Society of Rheumatology Lupus Registry) is a nationwide multicentre, hospital-based registry of SLE patients. This is a cross-sectional study. The main variable was polyautoimmunity, which was defined as the co-occurrence of SLE and another autoimmune disease, such as autoimmune thyroiditis, RA, scleroderma, inflammatory myopathy and MCTD. We also recorded the presence of multiple autoimmune syndrome, secondary SS, secondary APS and a family history of autoimmune disease. Multiple logistic regression analysis was performed to investigate possible risk factors for polyautoimmunity. Results. Of the 3679 patients who fulfilled the criteria for SLE, 502 (13.6%) had polyautoimmunity. The most frequent types were autoimmune thyroiditis (7.9%), other systemic autoimmune diseases (6.2%), secondary SS (14.1%) and secondary APS (13.7%). Multiple autoimmune syndrome accounted for 10.2% of all cases of polyautoimmunity. A family history was recorded in 11.8%. According to the multivariate analysis, the factors associated with polyautoimmunity were female sex [odds ratio (95% CI), 1.72 (1.07, 2.72)], RP [1.63 (1.29, 2.05)], interstitial lung disease [3.35 (1.84, 6.01)], Jaccoud arthropathy [1.92 (1.40, 2.63)], anti-Ro/SSA and/or anti-La/SSB autoantibodies [2.03 (1.55, 2.67)], anti-RNP antibodies [1.48 (1.16, 1.90)], MTX [1.67 (1.26, 2.18)] and antimalarial drugs [0.50 (0.38, 0.67)]. Conclusion. Patients with SLE frequently present polyautoimmunity. We observed clinical and analytical characteristics associated with polyautoimmunity. Our finding that antimalarial drugs protected against polyautoimmunity should be verified in future studies.
publishDate	2020
dc.date.none.fl_str_mv	2020 2020-08-01 2020 2020-08-01
dc.type.none.fl_str_mv	research article http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://hdl.handle.net/20.500.13003/17217
url	https://hdl.handle.net/20.500.13003/17217
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial 4.0 International http://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial 4.0 International http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	Oxford Univ Press
publisher.none.fl_str_mv	Oxford Univ Press
dc.source.none.fl_str_mv	reponame:Docusalut instname:Conselleria de Salut i Consum del Govern de les Illes Balears
instname_str	Conselleria de Salut i Consum del Govern de les Illes Balears
reponame_str	Docusalut
collection	Docusalut
repository.name.fl_str_mv
repository.mail.fl_str_mv
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Hydroxychloroquine is associated with a lower risk of polyautoimmunity: data from the RELESSER Registry

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