Hydroxychloroquine is associated with a lower risk of polyautoimmunity: data from the RELESSER Registry

Objectives. This article estimates the frequency of polyautoimmunity and associated factors in a large retrospective cohort of patients with SLE. Methods. RELESSER (Spanish Society of Rheumatology Lupus Registry) is a nationwide multicentre, hospital-based registry of SLE patients. This is a cross-s...

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Detalles Bibliográficos
Autores: Mena-Vazquez, Natalia, Fernandez-Nebro, Antonio, Pego-Reigosa, Jose Maria, Galindo, Maria, Melissa-Anzola, Ana, Uriarte Isacelaya, Esther, Olive-Marques, Alejandro, Aurrecoechea, Elena, Freire, Mercedes, Tomero, Eva, Garcia-Villanueva, Maria Jesus, Stoye, Claudia, Salas-Heredia, Esteban, Bernal-Vidal, Jose Antonio, Salgado, Eva, Blanco, Ricardo, Novoa, Francisco Javier, Ibáñez-Barceló, Mónica, Torrente-Segarra, Vicente, Narvaez, Javier, Calvet, Joan, Moriano Morales, Clara, Vazquez-Rodriguez, Tomas, Garcia de la Pena, Paloma, Bohorquez, Cristina, Andreu-Sanchez, Jose Luis, Cobo-Ibáñez, Tatiana, Bonilla, Gema, Lozano-Rivas, Nuria, Montilla, Carlos, Toyos, Francisco Javier, Marenco De la Fuente, Jose Luis, Exposito, Lorena, Ruiz Lucea, Esther, Vals, Elia, Manero-Ruiz, Javier, Rua-Figueroa, Inigo
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Conselleria de Salut i Consum del Govern de les Illes Balears
Repositorio:Docusalut
Idioma:inglés
OAI Identifier:oai:docusalut.com:20.500.13003/17217
Acceso en línea:https://hdl.handle.net/20.500.13003/17217
Access Level:acceso abierto
Palabra clave:Cross-Sectional Studies
Antirheumatic Agents
Registries
Lupus Erythematosus, Systemic
Autoimmunity
Female
Male
Middle Aged
Hydroxychloroquine
Humans
Adult
Young Adult
Autoimmune Diseases
Adulto
Sistema de Registros
Enfermedades Autoinmunes
Adulto Joven
Antirreumáticos
Lupus Eritematoso Sistémico
Autoinmunidad
Femenino
Masculino
Hidroxicloroquina
Estudios Transversales
Humanos
Persona de Mediana Edad
polyautoimmunity
systemic lupus erythematosus
multiple autoimmune syndrome
Descripción
Sumario:Objectives. This article estimates the frequency of polyautoimmunity and associated factors in a large retrospective cohort of patients with SLE. Methods. RELESSER (Spanish Society of Rheumatology Lupus Registry) is a nationwide multicentre, hospital-based registry of SLE patients. This is a cross-sectional study. The main variable was polyautoimmunity, which was defined as the co-occurrence of SLE and another autoimmune disease, such as autoimmune thyroiditis, RA, scleroderma, inflammatory myopathy and MCTD. We also recorded the presence of multiple autoimmune syndrome, secondary SS, secondary APS and a family history of autoimmune disease. Multiple logistic regression analysis was performed to investigate possible risk factors for polyautoimmunity. Results. Of the 3679 patients who fulfilled the criteria for SLE, 502 (13.6%) had polyautoimmunity. The most frequent types were autoimmune thyroiditis (7.9%), other systemic autoimmune diseases (6.2%), secondary SS (14.1%) and secondary APS (13.7%). Multiple autoimmune syndrome accounted for 10.2% of all cases of polyautoimmunity. A family history was recorded in 11.8%. According to the multivariate analysis, the factors associated with polyautoimmunity were female sex [odds ratio (95% CI), 1.72 (1.07, 2.72)], RP [1.63 (1.29, 2.05)], interstitial lung disease [3.35 (1.84, 6.01)], Jaccoud arthropathy [1.92 (1.40, 2.63)], anti-Ro/SSA and/or anti-La/SSB autoantibodies [2.03 (1.55, 2.67)], anti-RNP antibodies [1.48 (1.16, 1.90)], MTX [1.67 (1.26, 2.18)] and antimalarial drugs [0.50 (0.38, 0.67)]. Conclusion. Patients with SLE frequently present polyautoimmunity. We observed clinical and analytical characteristics associated with polyautoimmunity. Our finding that antimalarial drugs protected against polyautoimmunity should be verified in future studies.

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