Reduced heart rate variability predicts fatigue severity in individuals with chronic fatigue syndrome/myalgic encephalomyelitis

Heart rate variability (HRV) is an objective, non-invasive tool to assessing autonomic dysfunction in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). People with CFS/ME tend to have lower HRV; however, in the literature there are only a few previous studies (most of them inconclusive) o...

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Autores: Escorihuela, Rosa M.|||0000-0001-9368-5173, Capdevila Ortís, Lluís|||0000-0002-7319-4745, Ramos Castro, Juan|||0000-0001-9413-2001, Zaragoza, Maria Cleofé|||0000-0002-9797-0219, Maurel, Sara, Alegre Martín, José|||0000-0002-7582-7585, Castro-Marrero, Jesús|||0000-0002-2481-3052
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:226168
Acceso en línea:https://ddd.uab.cat/record/226168
https://dx.doi.org/urn:doi:10.1186/s12967-019-02184-z
Access Level:acceso abierto
Palabra clave:Autonomic dysfunction
Chronic fatigue syndrome
Fatigue
Heart rate variability
Myalgic encephalomyelitis
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spelling Reduced heart rate variability predicts fatigue severity in individuals with chronic fatigue syndrome/myalgic encephalomyelitisEscorihuela, Rosa M.|||0000-0001-9368-5173Capdevila Ortís, Lluís|||0000-0002-7319-4745Ramos Castro, Juan|||0000-0001-9413-2001Zaragoza, Maria Cleofé|||0000-0002-9797-0219Maurel, SaraAlegre Martín, José|||0000-0002-7582-7585Castro-Marrero, Jesús|||0000-0002-2481-3052Autonomic dysfunctionChronic fatigue syndromeFatigueHeart rate variabilityMyalgic encephalomyelitisHeart rate variability (HRV) is an objective, non-invasive tool to assessing autonomic dysfunction in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). People with CFS/ME tend to have lower HRV; however, in the literature there are only a few previous studies (most of them inconclusive) on their association with illness-related complaints. To address this issue, we assessed the value of different diurnal HRV parameters as potential biomarker in CFS/ME and also investigated the relationship between these HRV indices and self-reported symptoms in individuals with CFS/ME. In this case-control study, 45 female patients who met the 1994 CDC/Fukuda definition for CFS/ME and 25 age- and gender-matched healthy controls underwent HRV recording-resting state tests. The intervals between consecutive heartbeats (RR) were continuously recorded over three 5-min periods. Time- and frequency-domain analyses were applied to estimate HRV variables. Demographic and clinical features, and self-reported symptom measures were also recorded. CFS/ME patients showed significantly higher scores in all symptom questionnaires (p < 0.001), decreased RR intervals (p < 0.01), and decreased HRV time- and frequency-domain parameters (p < 0.005), except for the LF/HF ratio than in the healthy controls. Overall, the correlation analysis reached significant associations between the questionnaires scores and HRV time- and frequency-domain measurements (p < 0.05). Furthermore, separate linear regression analyses showed significant relationships between self-reported fatigue symptoms and mean RR (p = 0.005), RMSSD (p = 0.0268) and HFnu indices (p = 0.0067) in CFS/ME patients, but not in healthy controls. Our findings suggest that ANS dysfunction presenting as increased sympathetic hyperactivity may contribute to fatigue severity in individuals with ME/CFS. Further studies comparing short- and long-term HRV recording and self-reported outcome measures with previous studies in larger CFS/ME cohorts are urgently warranted. 22020-01-0120202020-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/226168https://dx.doi.org/urn:doi:10.1186/s12967-019-02184-zreponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengMinisterio de Economía y Competitividad https://doi.org/10.13039/501100003329 DEP2015-68538-C2-1-Ropen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2261682026-06-06T12:50:31Z
dc.title.none.fl_str_mv Reduced heart rate variability predicts fatigue severity in individuals with chronic fatigue syndrome/myalgic encephalomyelitis
title Reduced heart rate variability predicts fatigue severity in individuals with chronic fatigue syndrome/myalgic encephalomyelitis
spellingShingle Reduced heart rate variability predicts fatigue severity in individuals with chronic fatigue syndrome/myalgic encephalomyelitis
Escorihuela, Rosa M.|||0000-0001-9368-5173
Autonomic dysfunction
Chronic fatigue syndrome
Fatigue
Heart rate variability
Myalgic encephalomyelitis
title_short Reduced heart rate variability predicts fatigue severity in individuals with chronic fatigue syndrome/myalgic encephalomyelitis
title_full Reduced heart rate variability predicts fatigue severity in individuals with chronic fatigue syndrome/myalgic encephalomyelitis
title_fullStr Reduced heart rate variability predicts fatigue severity in individuals with chronic fatigue syndrome/myalgic encephalomyelitis
title_full_unstemmed Reduced heart rate variability predicts fatigue severity in individuals with chronic fatigue syndrome/myalgic encephalomyelitis
title_sort Reduced heart rate variability predicts fatigue severity in individuals with chronic fatigue syndrome/myalgic encephalomyelitis
dc.creator.none.fl_str_mv Escorihuela, Rosa M.|||0000-0001-9368-5173
Capdevila Ortís, Lluís|||0000-0002-7319-4745
Ramos Castro, Juan|||0000-0001-9413-2001
Zaragoza, Maria Cleofé|||0000-0002-9797-0219
Maurel, Sara
Alegre Martín, José|||0000-0002-7582-7585
Castro-Marrero, Jesús|||0000-0002-2481-3052
author Escorihuela, Rosa M.|||0000-0001-9368-5173
author_facet Escorihuela, Rosa M.|||0000-0001-9368-5173
Capdevila Ortís, Lluís|||0000-0002-7319-4745
Ramos Castro, Juan|||0000-0001-9413-2001
Zaragoza, Maria Cleofé|||0000-0002-9797-0219
Maurel, Sara
Alegre Martín, José|||0000-0002-7582-7585
Castro-Marrero, Jesús|||0000-0002-2481-3052
author_role author
author2 Capdevila Ortís, Lluís|||0000-0002-7319-4745
Ramos Castro, Juan|||0000-0001-9413-2001
Zaragoza, Maria Cleofé|||0000-0002-9797-0219
Maurel, Sara
Alegre Martín, José|||0000-0002-7582-7585
Castro-Marrero, Jesús|||0000-0002-2481-3052
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Autonomic dysfunction
Chronic fatigue syndrome
Fatigue
Heart rate variability
Myalgic encephalomyelitis
topic Autonomic dysfunction
Chronic fatigue syndrome
Fatigue
Heart rate variability
Myalgic encephalomyelitis
description Heart rate variability (HRV) is an objective, non-invasive tool to assessing autonomic dysfunction in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). People with CFS/ME tend to have lower HRV; however, in the literature there are only a few previous studies (most of them inconclusive) on their association with illness-related complaints. To address this issue, we assessed the value of different diurnal HRV parameters as potential biomarker in CFS/ME and also investigated the relationship between these HRV indices and self-reported symptoms in individuals with CFS/ME. In this case-control study, 45 female patients who met the 1994 CDC/Fukuda definition for CFS/ME and 25 age- and gender-matched healthy controls underwent HRV recording-resting state tests. The intervals between consecutive heartbeats (RR) were continuously recorded over three 5-min periods. Time- and frequency-domain analyses were applied to estimate HRV variables. Demographic and clinical features, and self-reported symptom measures were also recorded. CFS/ME patients showed significantly higher scores in all symptom questionnaires (p < 0.001), decreased RR intervals (p < 0.01), and decreased HRV time- and frequency-domain parameters (p < 0.005), except for the LF/HF ratio than in the healthy controls. Overall, the correlation analysis reached significant associations between the questionnaires scores and HRV time- and frequency-domain measurements (p < 0.05). Furthermore, separate linear regression analyses showed significant relationships between self-reported fatigue symptoms and mean RR (p = 0.005), RMSSD (p = 0.0268) and HFnu indices (p = 0.0067) in CFS/ME patients, but not in healthy controls. Our findings suggest that ANS dysfunction presenting as increased sympathetic hyperactivity may contribute to fatigue severity in individuals with ME/CFS. Further studies comparing short- and long-term HRV recording and self-reported outcome measures with previous studies in larger CFS/ME cohorts are urgently warranted.
publishDate 2020
dc.date.none.fl_str_mv 2
2020-01-01
2020
2020-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/226168
https://dx.doi.org/urn:doi:10.1186/s12967-019-02184-z
url https://ddd.uab.cat/record/226168
https://dx.doi.org/urn:doi:10.1186/s12967-019-02184-z
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 DEP2015-68538-C2-1-R
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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