Heart rate variability spectrum characteristics in children with sleep apnea

Background Classic spectral analysis of heart rate variability (HRV) in pediatric sleep apnea–hypopnea syndrome (SAHS) traditionally evaluates the very low frequency (VLF: 0–0.04 Hz), low frequency (LF: 0.04–0.15 Hz), and high frequency (HF: 0.15–0.40 Hz) bands. However, specific SAHS-related freque...

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Autores: Martín Montero, Adrián, Gutierrez Tobal, Gonzalo César, Kheirandish Gozal, Leila, Jimenez García, Jorge, Álvarez González, Daniel, Campo Matias, Félix del, Gozal, David, Hornero Sánchez, Roberto
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2020
País:España
Institución:Universidad de Valladolid
Repositorio:UVaDOC. Repositorio Documental de la Universidad de Valladolid
OAI Identifier:oai:uvadoc.uva.es:10324/81685
Acceso en línea:https://doi.org/10.1038/s41390-020-01138-2
https://uvadoc.uva.es/handle/10324/81685
Access Level:acceso abierto
Palabra clave:3314 Tecnología Médica
3325 Tecnología de las Telecomunicaciones
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spelling Heart rate variability spectrum characteristics in children with sleep apneaMartín Montero, AdriánGutierrez Tobal, Gonzalo CésarKheirandish Gozal, LeilaJimenez García, JorgeÁlvarez González, DanielCampo Matias, Félix delGozal, DavidHornero Sánchez, Roberto3314 Tecnología Médica3325 Tecnología de las TelecomunicacionesBackground Classic spectral analysis of heart rate variability (HRV) in pediatric sleep apnea–hypopnea syndrome (SAHS) traditionally evaluates the very low frequency (VLF: 0–0.04 Hz), low frequency (LF: 0.04–0.15 Hz), and high frequency (HF: 0.15–0.40 Hz) bands. However, specific SAHS-related frequency bands have not been explored. Methods One thousand seven hundred and thirty-eight HRV overnight recordings from two pediatric databases (0–13 years) were evaluated. The first one (981 children) served as training set to define new HRV pediatric SAHS-related frequency bands. The associated relative power (RP) were computed in the test set, the Childhood Adenotonsillectomy Trial database (CHAT, 757 children). Their relationships with polysomnographic variables and diagnostic ability were assessed. Results Two new specific spectral bands of pediatric SAHS within 0–0.15 Hz were related to duration of apneic events, number of awakenings, and wakefulness after sleep onset (WASO), while an adaptive individual-specific new band from HF was related to oxyhemoglobin desaturations, arousals, and WASO. Furthermore, these new spectral bands showed improved diagnostic ability than classic HRV. Conclusions Novel spectral bands provide improved characterization of pediatric SAHS. These findings may pioneer a better understanding of the effects of SAHS on cardiac function and potentially serve as detection biomarkers.This work was supported by “Ministerio de Ciencia, Innovación y Universidades” and “European Regional Development Fund (FEDER)” under projects DPI2017-84280-R and RTC-2017-6516-1, by “European Commission” and “FEDER” under projects “Análisis y correlación entre el genoma completo y la actividad cerebral para la ayuda en el diagnóstico de la enfermedad de Alzheimer” and “Análisis y correlación entre la epigenética y la actividad cerebral para evaluar el riesgo de migraña crónica y episódica en mujeres” (“Cooperation Programme Interreg V-A Spain-Portugal POCTEP 2014–2020”), and by “CIBER en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN)” through “Instituto de Salud Carlos III” co-funded with FEDER funds. A.M.-M. was in receipt of a “Ayudas para contratos predoctorales para la Formación de Doctores” grant from the Ministerio de Ciencia, Innovación y Universidades (PRE2018–085219). J.J.-G. was in receipt of a “Ayudas para la contratación de personal técnico de apoyo a la investigación” grant from the “Junta de Castilla y León” funded by the European Social Fund and Youth Employment Initiative. L.K.-G. and D.G. were supported by National Institutes of Health (NIH) grant HL130984.Springer Nature2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://doi.org/10.1038/s41390-020-01138-2https://uvadoc.uva.es/handle/10324/81685reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolidinstname:Universidad de ValladolidEspañolinfo:eu-repo/semantics/openAccessoai:uvadoc.uva.es:10324/816852026-06-13T12:44:47Z
dc.title.none.fl_str_mv Heart rate variability spectrum characteristics in children with sleep apnea
title Heart rate variability spectrum characteristics in children with sleep apnea
spellingShingle Heart rate variability spectrum characteristics in children with sleep apnea
Martín Montero, Adrián
3314 Tecnología Médica
3325 Tecnología de las Telecomunicaciones
title_short Heart rate variability spectrum characteristics in children with sleep apnea
title_full Heart rate variability spectrum characteristics in children with sleep apnea
title_fullStr Heart rate variability spectrum characteristics in children with sleep apnea
title_full_unstemmed Heart rate variability spectrum characteristics in children with sleep apnea
title_sort Heart rate variability spectrum characteristics in children with sleep apnea
dc.creator.none.fl_str_mv Martín Montero, Adrián
Gutierrez Tobal, Gonzalo César
Kheirandish Gozal, Leila
Jimenez García, Jorge
Álvarez González, Daniel
Campo Matias, Félix del
Gozal, David
Hornero Sánchez, Roberto
author Martín Montero, Adrián
author_facet Martín Montero, Adrián
Gutierrez Tobal, Gonzalo César
Kheirandish Gozal, Leila
Jimenez García, Jorge
Álvarez González, Daniel
Campo Matias, Félix del
Gozal, David
Hornero Sánchez, Roberto
author_role author
author2 Gutierrez Tobal, Gonzalo César
Kheirandish Gozal, Leila
Jimenez García, Jorge
Álvarez González, Daniel
Campo Matias, Félix del
Gozal, David
Hornero Sánchez, Roberto
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv 3314 Tecnología Médica
3325 Tecnología de las Telecomunicaciones
topic 3314 Tecnología Médica
3325 Tecnología de las Telecomunicaciones
description Background Classic spectral analysis of heart rate variability (HRV) in pediatric sleep apnea–hypopnea syndrome (SAHS) traditionally evaluates the very low frequency (VLF: 0–0.04 Hz), low frequency (LF: 0.04–0.15 Hz), and high frequency (HF: 0.15–0.40 Hz) bands. However, specific SAHS-related frequency bands have not been explored. Methods One thousand seven hundred and thirty-eight HRV overnight recordings from two pediatric databases (0–13 years) were evaluated. The first one (981 children) served as training set to define new HRV pediatric SAHS-related frequency bands. The associated relative power (RP) were computed in the test set, the Childhood Adenotonsillectomy Trial database (CHAT, 757 children). Their relationships with polysomnographic variables and diagnostic ability were assessed. Results Two new specific spectral bands of pediatric SAHS within 0–0.15 Hz were related to duration of apneic events, number of awakenings, and wakefulness after sleep onset (WASO), while an adaptive individual-specific new band from HF was related to oxyhemoglobin desaturations, arousals, and WASO. Furthermore, these new spectral bands showed improved diagnostic ability than classic HRV. Conclusions Novel spectral bands provide improved characterization of pediatric SAHS. These findings may pioneer a better understanding of the effects of SAHS on cardiac function and potentially serve as detection biomarkers.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1038/s41390-020-01138-2
https://uvadoc.uva.es/handle/10324/81685
url https://doi.org/10.1038/s41390-020-01138-2
https://uvadoc.uva.es/handle/10324/81685
dc.language.none.fl_str_mv Español
language_invalid_str_mv Español
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolid
instname:Universidad de Valladolid
instname_str Universidad de Valladolid
reponame_str UVaDOC. Repositorio Documental de la Universidad de Valladolid
collection UVaDOC. Repositorio Documental de la Universidad de Valladolid
repository.name.fl_str_mv
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