Deep Sequencing Reveals Occult Mansonellosis Coinfections in Residents From the Brazilian Amazon Village of São Gabriel da Cachoeira

Mansonella ozzardi and Mansonella perstans infections both cause mansonellosis but are usually treated differently. Using a real-time polymerase chain reaction assay and deep sequencing, we reveal the presence of mansonellosis coinfections that were undetectable by standard diagnostic methods. Our r...

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Bibliographic Details
Authors: Crainey, James Lee, Aguiar Costa, Carlos Henrique, Ferreira de Oliveira Leles, Lorena, Ribeiro da Silva, Túllio Romão, de Aquino Narzetti, Luiz Henrique, Vinícius Serra Dos Santos, Yago, Costa Conteville, Liliane, Costa Pessoa, Felipe Arley, Carvajal Cortés, José Joaquin, Paulo Vicente, Ana Carolina, Rubio Muñoz, Jose Miguel, Bessa Luz, Sérgio Luiz
Format: article
Publication Date:2020
Country:España
Institution:Instituto de Salud Carlos III (ISCIII)
Repository:Repisalud
Language:English
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/26157
Online Access:https://hdl.handle.net/20.500.12105/26157
Access Level:Open access
Keyword:Mansonella ozzardi
Mansonella perstans
Brazil
Coinfections
Mansonellosis
Animals
Coinfection
High-Throughput Nucleotide Sequencing
Humans
Mansonella
Mansonelliasis
Description
Summary:Mansonella ozzardi and Mansonella perstans infections both cause mansonellosis but are usually treated differently. Using a real-time polymerase chain reaction assay and deep sequencing, we reveal the presence of mansonellosis coinfections that were undetectable by standard diagnostic methods. Our results confirm mansonellosis coinfections and have important implications for the disease's treatment and diagnosis.

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