Implication of Voltage-Gated Potassium Channels in Neoplastic Cell Proliferation

Voltage-gated potassium channels (Kv) are the largest group of ion channels. Kv are involved in controlling the resting potential and action potential duration in the heart and brain. Additionally, these proteins participate in cell cycle progression as well as in several other important features in...

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Autores: Serrano-Novillo, Clara, Capera, Jesusa|||0000-0002-8123-7725, Colomer-Molera, Magalí, Condom, Enric|||0000-0003-0142-3729, Ferreres Piñas, Joan Carles|||0000-0001-7742-0239, Felipe, Antonio|||0000-0002-7294-6431
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:226375
Acceso en línea:https://ddd.uab.cat/record/226375
https://dx.doi.org/urn:doi:10.3390/cancers11030287
Access Level:acceso abierto
Palabra clave:K + channels
Cancer
Tumor progression
Cell cycle
Proliferation
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spelling Implication of Voltage-Gated Potassium Channels in Neoplastic Cell ProliferationSerrano-Novillo, ClaraCapera, Jesusa|||0000-0002-8123-7725Colomer-Molera, MagalíCondom, Enric|||0000-0003-0142-3729Ferreres Piñas, Joan Carles|||0000-0001-7742-0239Felipe, Antonio|||0000-0002-7294-6431K + channelsCancerTumor progressionCell cycleProliferationVoltage-gated potassium channels (Kv) are the largest group of ion channels. Kv are involved in controlling the resting potential and action potential duration in the heart and brain. Additionally, these proteins participate in cell cycle progression as well as in several other important features in mammalian cell physiology, such as activation, differentiation, apoptosis, and cell volume control. Therefore, Kv remarkably participate in the cell function by balancing responses. The implication of Kv in physiological and pathophysiological cell growth is the subject of study, as Kv are proposed as therapeutic targets for tumor regression. Though it is widely accepted that Kv channels control proliferation by allowing cell cycle progression, their role is controversial. Kv expression is altered in many cancers, and their participation, as well as their use as tumor markers, is worthy of effort. There is an ever-growing list of Kv that remodel during tumorigenesis. This review focuses on the actual knowledge of Kv channel expression and their relationship with neoplastic proliferation. In this work, we provide an update of what is currently known about these proteins, thereby paving the way for a more precise understanding of the participation of Kv during cancer development. 22019-01-0120192019-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/226375https://dx.doi.org/urn:doi:10.3390/cancers11030287reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengMinisterio de Economía y Competitividad https://doi.org/10.13039/501100003329 BFU2011-23268Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 BFU2014-54928-RAgencia Estatal de Investigación https://doi.org/10.13039/501100011033 BFU2017-87104-Ropen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2263752026-06-06T12:50:31Z
dc.title.none.fl_str_mv Implication of Voltage-Gated Potassium Channels in Neoplastic Cell Proliferation
title Implication of Voltage-Gated Potassium Channels in Neoplastic Cell Proliferation
spellingShingle Implication of Voltage-Gated Potassium Channels in Neoplastic Cell Proliferation
Serrano-Novillo, Clara
K + channels
Cancer
Tumor progression
Cell cycle
Proliferation
title_short Implication of Voltage-Gated Potassium Channels in Neoplastic Cell Proliferation
title_full Implication of Voltage-Gated Potassium Channels in Neoplastic Cell Proliferation
title_fullStr Implication of Voltage-Gated Potassium Channels in Neoplastic Cell Proliferation
title_full_unstemmed Implication of Voltage-Gated Potassium Channels in Neoplastic Cell Proliferation
title_sort Implication of Voltage-Gated Potassium Channels in Neoplastic Cell Proliferation
dc.creator.none.fl_str_mv Serrano-Novillo, Clara
Capera, Jesusa|||0000-0002-8123-7725
Colomer-Molera, Magalí
Condom, Enric|||0000-0003-0142-3729
Ferreres Piñas, Joan Carles|||0000-0001-7742-0239
Felipe, Antonio|||0000-0002-7294-6431
author Serrano-Novillo, Clara
author_facet Serrano-Novillo, Clara
Capera, Jesusa|||0000-0002-8123-7725
Colomer-Molera, Magalí
Condom, Enric|||0000-0003-0142-3729
Ferreres Piñas, Joan Carles|||0000-0001-7742-0239
Felipe, Antonio|||0000-0002-7294-6431
author_role author
author2 Capera, Jesusa|||0000-0002-8123-7725
Colomer-Molera, Magalí
Condom, Enric|||0000-0003-0142-3729
Ferreres Piñas, Joan Carles|||0000-0001-7742-0239
Felipe, Antonio|||0000-0002-7294-6431
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv K + channels
Cancer
Tumor progression
Cell cycle
Proliferation
topic K + channels
Cancer
Tumor progression
Cell cycle
Proliferation
description Voltage-gated potassium channels (Kv) are the largest group of ion channels. Kv are involved in controlling the resting potential and action potential duration in the heart and brain. Additionally, these proteins participate in cell cycle progression as well as in several other important features in mammalian cell physiology, such as activation, differentiation, apoptosis, and cell volume control. Therefore, Kv remarkably participate in the cell function by balancing responses. The implication of Kv in physiological and pathophysiological cell growth is the subject of study, as Kv are proposed as therapeutic targets for tumor regression. Though it is widely accepted that Kv channels control proliferation by allowing cell cycle progression, their role is controversial. Kv expression is altered in many cancers, and their participation, as well as their use as tumor markers, is worthy of effort. There is an ever-growing list of Kv that remodel during tumorigenesis. This review focuses on the actual knowledge of Kv channel expression and their relationship with neoplastic proliferation. In this work, we provide an update of what is currently known about these proteins, thereby paving the way for a more precise understanding of the participation of Kv during cancer development.
publishDate 2019
dc.date.none.fl_str_mv 2
2019-01-01
2019
2019-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/226375
https://dx.doi.org/urn:doi:10.3390/cancers11030287
url https://ddd.uab.cat/record/226375
https://dx.doi.org/urn:doi:10.3390/cancers11030287
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 BFU2011-23268
Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 BFU2014-54928-R
Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 BFU2017-87104-R
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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